North Carolina is currently home to 2648 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
NCT04097145
Recruiting
To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Repair System in patients with symptomatic severe tricuspid regurgitation who have been determined to be at an intermediate or greater estimated risk of mortality with tricuspid valve surgery by the cardiac surgeon with concurrence by the local Heart Team
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
Register for Updates
Adolescents Living With HIV (ALWH): Social Networks, Adherence and Retention
NCT04077047
Recruiting
human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) is the second leading cause of death in Africa. Adolescents living with HIV (ALWH) are at increased risk for HIV-related morbidity and mortality due to poor retention in HIV care and suboptimal antiretroviral therapy (ART) adherence. Despite having the world's largest population of Adolescents living with HIV (ALWH) (15-24 years, n=870,000), only 14% of South African ALWH are on ART, 12% are retained in HIV care 1-2 yea... Read More
Gender:
ALL
Ages:
Between 15 years and 21 years
Trial Updated:
05/27/2025
Locations: Wake Forest University School of Medicine, Winston-Salem, North Carolina
Conditions: HIV/AIDS
Register for Updates
Prospective Measurement of Normal Venous Sinus Pressures
NCT03948971
Recruiting
The purpose of this research is to document normal intracranial venous sinus pressures. Participants who need to have a cerebral angiogram to evaluate a medical problem not related to Idiopathic Intracranial Hypertension (IIH) will be invited to participate. Participation in this research will not require any extra visits. The intervention will take place in the interventional radiology suite when the subject has an angiogram. IIH is a condition that causes increased pressure in the brain in the... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/27/2025
Locations: Wake Forest Univesity Health Sciences, Winston-Salem, North Carolina
Conditions: Intracranial Venous Pressures
Register for Updates
Ferritin and Iron Burden in SAH sIRB
NCT03754725
Recruiting
Ruptured cerebral aneurysms lead to subarachnoid hemorrhage (SAH),that has a high morbidity and mortality rate, the severity of which is predicted by the "Hunt-Hess grade" (HHG). SAH leads to iron (Fe) and hemoglobin (Hb) accumulation in the brain, which is toxic for neurons. Ferritin (iron reported in the brian) and iron overload leads to brain atrophy, specifically in the mesial temporal lobe (hippocampus, impairing patients' cognition. It is estimated that 50% of survivors have cognitive def... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/27/2025
Locations: Duke University Health System, Durham, North Carolina
Conditions: SAH, Dementia
Register for Updates
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
NCT02855476
Recruiting
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development.
Gender:
ALL
Ages:
Between 11 years and 75 years
Trial Updated:
05/27/2025
Locations: Wake Forest University, Winston-Salem, North Carolina
Conditions: Huntington's Disease
Register for Updates
GBE Deficiency (GSD IV and APBD) Natural History Study
NCT02683512
Recruiting
Collection and review of clinical information related to glycogen branching enzyme (GBE) deficiency, diagnosed as Glycogen Storage Disease Type IV (GSD IV) or Adult Polyglucosan Body Disease (APBD generated during clinic visits.
Gender:
ALL
Ages:
Between 0 years and 90 years
Trial Updated:
05/27/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Glycogen Storage Disease Type IV, Adult Polyglucosan Body Disease, GSD4, GSD IV, APBD
Register for Updates
Muscle Fiber Fragment Treatment for Urinary Incontinence
NCT01953263
Recruiting
This study is designed to evaluate the safety of autologous muscle fiber fragments for the treatment of urinary incontinence due to incompetent outlet (bladder neck/urethra).
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
05/27/2025
Locations: Wake Forest Urology Clinic, Winston-Salem, North Carolina
Conditions: Urinary Incontinence
Register for Updates
Pharmacokinetics of Off Label Pediatric Medications
NCT01286519
Recruiting
The purpose of this study is to measure the level of medicines found in body fluids such as blood, urine, spinal fluid of children.
Gender:
ALL
Ages:
Between 1 day and 8 years
Trial Updated:
05/27/2025
Locations: University of North Carolina NC Children's Hospital, Chapel Hill, North Carolina
Conditions: Off Label Use of Medications in Pediatric Patients
Register for Updates
A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis
NCT07003425
Recruiting
This is a multicenter, double-blind, Long-Term Extension (LTE) study to evaluate the long-term safety and efficacy of APG777 in patients with moderate-to-severe AD who have completed treatment in an APG777 Parent Study (NCT06395948). The LTE study will consist of 3 periods: 1) Screening Visit will coincide with the last visit of the Maintenance Period in the Parent Study 2) Extended Treatment Period 3) Post-treatment Follow-up Period. This study will be conducted in participants with atopic de... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/26/2025
Locations: Investigational Site #29, Wilmington, North Carolina
Conditions: Atopic Dermatitis
Register for Updates
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD
NCT06883305
Recruiting
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
05/26/2025
Locations: Research Site, High Point, North Carolina
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Register for Updates
A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy
NCT06797869
Recruiting
This study will look at the effects of CagriSema in people with both type 2 diabetes and painful diabetic peripheral neuropathy, compared to placebo. Participants will either get an active medicine or a "dummy" medicine (placebo). Which treatment participants get is decided by chance. In this study the active, investigational medicine is called CagriSema. Doctors cannot yet prescribe CagriSema. For each participant, the study will last for about 10 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/26/2025
Locations: Piedmont Healthcare/Research, Statesville, North Carolina
Conditions: Diabetes Mellitus, Type 2, Diabetic Peripheral Neuropathy
Register for Updates
A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms
NCT06693648
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, parallel group, 6-week trial of a formulation of AMZ001 once daily versus placebo once daily.
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
05/26/2025
Locations: West Clinical Research, Morehead City, North Carolina
Conditions: Osteoarthritis of Knee, Osteoarthritis, Knee
Register for Updates