North Carolina is currently home to 2641 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma
NCT04609046
Recruiting
This phase I trial tests the safety, side effects, best dose and effectiveness of lenalidomide when added to nivolumab and the usual drugs (rituximab and methotrexate) in patients with primary central nervous system (CNS) lymphoma. Lenalidomide may stop or slow primary CNS lymphoma by blocking the growth of new blood vessels necessary for tumor growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the abil... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Conditions: Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System
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An Internet-based Program to Help Cancer Survivors Manage Pain
NCT04462302
Recruiting
To determine whether an Internet-based pain coping skills program plus enhanced usual care, compared to enhanced usual care alone, yields significant improvements in the co-primary outcomes of pain severity (as measured by the Brief Pain Inventory (BPI)) and pain interference (also measured by the BPI) from baseline to the post-intervention assessment for cancer survivors with persistent pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: Wake Forest University at Clemmons, Clemmons, North Carolina
Conditions: Cancer
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Fabry Disease Registry & Pregnancy Sub-registry
NCT00196742
Recruiting
The Fabry Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Fabry disease, irrespective of treatment status. No experimental intervention is involved; patients in the Registry undergo clinical assessments and receive care as determined by the patient's treating physician. The primary objectives of the Registry are: * To enhance the understanding of the variability, progression, and natural history of F... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/07/2025
Locations: Carolinas Medical Center- Site Number : 840065, Charlotte, North Carolina
Conditions: Fabry Disease
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Developing a Digital Aid to Improve ICD Decisions
NCT07084142
Recruiting
Advanced heart failure, affecting 7 million Americans, has multiple causes and results in greatly increased risk of disability and death. A major problem is sudden cardiac death, when the damaged heart develops an abnormal pattern of electrical conduction that can result in cessation of heart activity. While placement of an Implantable Cardioverter-Defibrillator (ICD) in a patient's chest can help prevent sudden cardiac death, these devices have several important downsides. This protocol focuses... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/06/2025
Locations: Eastern Carolina University, Greenville, North Carolina
Conditions: Heart Failure and Reduced Ejection Fraction
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A Study to Evaluate ARV-806 in Adults With Advanced Cancer That Has the KRAS G12D Mutation
NCT07023731
Recruiting
This is a study to evaluate the safety and potential anti-tumor activity of an investigational agent called ARV-806 in Adults with Advanced Cancer having a specific KRAS mutation. This is an open-label study which means that participants and study staff will know that all participants will receive ARV-806. Researchers think that ARV-806 can work by breaking down a specific protein with a mutation that is present in some tumors, which might help prevent or slow tumors from growing. This will be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Clinical Trial Site, Huntersville, North Carolina
Conditions: KRAS G12D Mutation, Advanced Solid Cancer
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Concentration of n-3 PUFA Monohydroxylated Derivatives in Male Adults With Obesity After n-3 PUFA Supplementation.
NCT06991296
Recruiting
The goal of this clinical trial is to learn if daily supplementation with SPM Active® can increase omega 3 polyunsaturated fatty acid derivatives and improve well-being in male adults with obesity. The main questions it aims to answer are: Does 2 g/day of SPM Active® for 12 weeks increase plasma levels of 14-hydroxydocosahexaenoic (HDHA), 17-HDHA, and 18-hydroxy eicosapentaenoic acid (HEPE)? Does 2 g/day of SPM Active® for 12 weeks improve self-reported burnout, life satisfaction, and sleep qu... Read More
Gender:
MALE
Ages:
Between 45 years and 60 years
Trial Updated:
08/06/2025
Locations: UNC Nutrition Research Institute, Kannapolis, North Carolina
Conditions: Obesity
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A Study to Assess the Safety and Efficacy of Oral LPCN 1154A in Women With Severe PPD
NCT06979544
Recruiting
The purpose of this research study is to test the study drug, LPCN 1154A, as a possible treatment for postpartum depression (PPD). The trial aims to determine: * If LPCN 1154A reduces depressive symptoms in subjects with severe PPD * How well LPCN 1154A is tolerated and what side effects it may cause * If LPCN 1154A reduces anxiety symptoms in subjects with severe PPD
Gender:
FEMALE
Ages:
Between 15 years and 45 years
Trial Updated:
08/06/2025
Locations: Monroe Biomedical Research, Monroe, North Carolina
Conditions: Depression, Postpartum, Depression, Post-Partum, Postpartum Depression (PPD), Post-Natal Depression, Peripartum Depression, Postnatal Depression
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Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)
NCT06979154
Recruiting
The purpose of this study is to develop the safety, feasibility, and tolerability of a personalized transcranial alternating current stimulation (tACS) approach in antenatal depression.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/06/2025
Locations: Carolina Center for Neurostimulation, Chapel Hill, North Carolina
Conditions: Antenatal Depression, Major Depressive Disorder, Major Depressive Disorder in Pregnancy, Healthy Controls
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Affect-based Impulsivity in Borderline Personality Disorder
NCT06880640
Recruiting
The purpose of this research study is to investigate how personality traits and neuroendocrine systems relate to decision-making patterns in individuals 18-45 years old. The main question it aims to answer is how neuroendocrine activity impacts decision-making. Participants will complete online behavioral tasks, a stress induction procedure, self-report surveys, and a cognitive assessment. During the session, psychophysiological measures will be collected, including electrocardiogram (ECG) and... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
08/06/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Borderline Personality Disorder (BPD), Healthy Controls Group - Age and Sex-matched
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Testing Non-nutritive Sweetener Labels in Chile
NCT06842693
Recruiting
The goal of this experiment is to examine the effects of 2 types of non-nutritive sweetener (NNS) warning labels among a sample of Chilean parents. The main questions this experiment aims to answer are: Do non-nutritive sweetener warning labels improve consumers' ability to identify when a product contains non-nutritive sweeteners? Do non-nutritive sweetener warning labels impact on consumers' selection of non-nutritive sweetener-sweetened, unsweetened, and/or sugar-sweetened products for thei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: The University of North Carolina at Chapel Hill's Gillings School of Global Public Health, Chapel Hill, North Carolina
Conditions: Diet, Healthy
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Testing Ultraprocessed Food Labels in Chile
NCT06842680
Recruiting
The goal of this experiment is to examine the effects of a warning label signaling that a product is ultraprocessed among a sample of Chilean parents. The main questions this experiment aims to answer are: Do ultraprocessed warning labels on their own impact product purchase intentions? Do ultraprocessed warning labels impact product purchase intentions in the presence of nutrient warning labels? Do ultraprocessed warning labels help more consumers identify ultraprocessed foods? Participants... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: The University of North Carolina at Chapel Hill's Gillings School of Global Public Health, Chapel Hill, North Carolina
Conditions: Diet, Healthy
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A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced Participants With Active Psoriatic Arthritis
NCT06807424
Recruiting
The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in biologic-experienced participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Joint and Muscle Research Institute, Charlotte, North Carolina
Conditions: Arthritis, Psoriatic
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