North Carolina is currently home to 2641 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
NCT04879329
Recruiting
This study is being done to see if a drug called disitamab vedotin, alone or with pembrolizumab, works to treat HER2 expressing urothelial cancer. It will also test how safe the drug is for participants. Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic). It will also study what side effects happen when participants get the drug. A side effect is anything a drug does... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Urothelial Carcinoma
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Zenith® Fenestrated+ Clinical Study
NCT04875429
Recruiting
The Zenith® Fenestrated+ Endovascular Graft Clinical Study will assess the safety and effectiveness of the Zenith® Fenestrated+ Endovascular Graft (ZFEN+) in combination with the BeGraft Balloon-Expandable FEVAR Bridging Stent Graft System (BeGraft) and Unibody2 for the treatment of patients with aortic aneurysms involving one or more of the major visceral arteries.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm, Extent IV Thoracoabdominal, Pararenal Aneurysm
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Clinical Utility of Residual Hearing in the Cochlear Implant Ear
NCT04707885
Recruiting
The current study is a randomized multi-center clinical trial that investigates the role an intraoperative hearing monitoring system (electrocochleography) has on helping to save residual hearing in patients undergoing cochlear implantation (CI).
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
08/06/2025
Locations: University of North Carolina, Chapel Hill, Chapel Hill, North Carolina
Conditions: Hearing Loss, Sensorineural, Hearing Loss, Hearing Loss, Bilateral
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Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer
NCT04633239
Recruiting
This phase I/Ib trial identifies the side effects and best dose of abemaciclib when given together with olaparib in treating patients with ovarian cancer that responds at first to treatment with drugs that contain the metal platinum but then comes back within a certain period (recurrent platinum-resistant). Abemaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Recurrent Platinum-Resistant Ovarian Carcinoma, Recurrent Ovarian High Grade Serous Adenocarcinoma
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Enhancing Rural Health Via Cardiovascular Telehealth for Rural Patients Implementation (E-VICTORS)
NCT04617834
Recruiting
This pre-post study will evaluate the implementation of a cardiovascular telehealth platform, which will connect experts from the Wake Forest University Health Sciences (WFUHS) tertiary care center with Wilkes County Emergency Medical Services (WC-EMS) system, Wilkes Medical Center Emergency Department (ED), and The Wilkes County Health Department Public Health Community Clinic (PHCC) to improve cardiovascular care in this rural community.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Wilkes County Emergency Medical Services, Wilkesboro, North Carolina
Conditions: Cardiovascular Diseases, Acute Coronary Syndrome
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Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow
NCT04254185
Recruiting
This research is studying two surgical procedures in a large group of people to learn about how well these procedures work as a treatment for ulnar neuropathy at the elbow (UNE). Researchers want to see which surgery is more helpful for people with ulnar neuropathy. This research will determine if one surgery is better than the other to alleviate symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: OrthoCarolina Research Institute, Inc., Charlotte, North Carolina
Conditions: Neuropathy Ulnar
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Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation
NCT04088071
Recruiting
The primary purpose of this registry is to obtain real-world clinical experience of Paroxysmal (PAF) and Persistent (PsAF) Atrial Fibrillation ablation radiofrequency (RF) technologies. Data from the registry will be used to assess clinical outcomes, including procedural efficiency, safety, and long-term, effectiveness of catheter ablation with novel RF technologies in PAF and PsAF patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Mission Hospital, Asheville, North Carolina
Conditions: Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
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Total Shoulder Arthroplasty Multi-Center Registry
NCT03511586
Recruiting
The objective of the study is a multi-center prospective registry to collect clinical outcomes of anatomic and reverse total shoulder arthroplasty.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/06/2025
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Shoulder Arthroplasty
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Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma
NCT02704858
Recruiting
This multi-site, Phase 1/2a clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO100 (perillyl alcohol) for the treatment of patients with radiographically-confirmed progression of Grade IV glioma or recurrent primary or secondary Grade IV glioma. The study will have two phases, Phase 1 and Phase 2a. Phase 1 is a standard cohort dose escalation 3+3 design used to determine the maximum tolerated dose for Phase 2a. There will... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Glioblastoma Multiforme
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Pompe Disease Registry Protocol
NCT00231400
Recruiting
The Pompe Registry is a global, multicenter, international, longitudinal, observational, and voluntary program for patients with Pompe disease, designed to track the disease's natural history and outcomes in patients, both treated and not. Data from the Registry are also used to fulfill various global regulatory commitments, to support product development/reimbursement, and for other research and non-research related purposes. The objectives of the Registry are: * To enhance understanding of t... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/06/2025
Locations: Carolinas Medical Center Hospital- Site Number : 840065, Charlotte, North Carolina
Conditions: Glycogen Storage Disease Type II, Pompe Disease
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WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
NCT06967805
Recruiting
A Phase 2a, Randomized, Double-blind, Placebo-Controlled Study of the Safety and Efficacy of MTX-463 in Participants with Idiopathic Pulmonary Fibrosis (IPF)
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/05/2025
Locations: WISPer site in Greensboro, NC, Greensboro, North Carolina
Conditions: Idiopathic Pulmonary Fibrosis
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REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome
NCT06914609
Recruiting
The purpose of this study is to evaluate the efficacy and safety of ION582 in children and adults with Angelman syndrome caused by a deletion or mutation of the UBE3A gene.
Gender:
ALL
Ages:
Between 2 years and 50 years
Trial Updated:
08/05/2025
Locations: University of North Carolina at Chapel Hill School of Medicine, Carrboro, North Carolina
Conditions: Angelman Syndrome
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