North Carolina is currently home to 2646 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Conversations You Want About Corona Virus Disease (COVID-19)
NCT05191420
Recruiting
Web-enabled virtual topical guide: develop virtual conversations for each concern and intensity level
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: Wake Forest Health Sciences, Winston-Salem, North Carolina
Conditions: Covid19
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A Study of NVL-520 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)
NCT05118789
Recruiting
Phase 1/2, dose escalation and expansion study designed to evaluate the safety and tolerability of NVL-520, determine the recommended phase 2 dose (RP2D), and evaluate the antitumor activity in patients with advanced ROS1-positive (ROS1+) NSCLC and other advanced ROS1-positive solid tumors. Phase 1 will determine the RP2D and, if applicable, the maximum tolerated dose (MTD) of NVL-520 in patients with advanced ROS1-positive solid tumors. Phase 2 will determine the objective response rate (ORR)... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
06/27/2025
Locations: Atrium Health Levine Cancer Institute, Charlotte, North Carolina
Conditions: Locally Advanced Solid Tumor, Metastatic Solid Tumor
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Safety and Efficacy Study of PF-06835375 in Primary Immune Thrombocytopenia
NCT05070845
Recruiting
This is a Phase 2, open-label, multicenter, multiple subcutaneous injection, safety and efficacy study of PF-06835375 in adult participants with primary immune thrombocytopenia (ITP). This study will focus on participants with persistent (\>3 months and ≤12 months), or chronic (\>12 months) ITP
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/27/2025
Locations: East Carolina University, Greenville, North Carolina
Conditions: Primary Immune Thrombocytopenia
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An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
NCT05066217
Recruiting
This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole HCL (EPX-100) as adjunctive therapy in children and adult participants with Lennox-Gastaut syndrome (LGS).
Gender:
ALL
Ages:
Between 2 years and 55 years
Trial Updated:
06/27/2025
Locations: On-Site Clinical Solution, Raleigh, North Carolina
Conditions: Lennox Gastaut Syndrome
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Women s Health Awareness Community Resiliency, Environmental Action and Collaborations for Health (REACH) Equity
NCT04983251
Recruiting
Background: Inequalities in COVID-19 infection, hospitalization, and death in under-studied, under-represented, and under-reported groups of people are severe. A growing number of studies have assessed the impact of individual risk factors. But few studies have assessed which factors are the greatest drivers of COVID-19 disparities from a wider perspective. Objective: To understand the long-term impacts of COVID-19 on minority women and their families to assist in developing community-based p... Read More
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
06/27/2025
Locations: NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina
Conditions: Mental Health
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Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
NCT04026776
Recruiting
The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.
Gender:
ALL
Ages:
Between 22 years and 33 years
Trial Updated:
06/27/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Salt; Excess, Blood Pressure Disorders
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Clinical and Molecular Studies in Families With Inherited Eye Disease
NCT02771236
Recruiting
Background: Genes are the basic units of heredity. When genes are changed, certain cells don t work like they should. Researchers want to try to better understand the genetic conditions that are linked with inherited eye diseases. Objective: To try to identify the genes linked to the development of inherited eye diseases. Eligibility: People ages 4 and older who have or have a family member with an inherited eye disease Design: Participants will be screened with medical history and medica... Read More
Gender:
ALL
Ages:
Between 4 years and 120 years
Trial Updated:
06/27/2025
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Inherited Eye Disease
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Feasibility of an ADAPTive Intervention to Improve Food Security and Maternal-Child Health
NCT06942598
Recruiting
Food insecurity affects up to 30% of pregnancies and leads to worse health in pregnant people and their children, including an increased risk of gestational diabetes, pre-term birth, and future cardiometabolic chronic conditions (e.g., type 2 diabetes and obesity). Interventions are being utilized to address food insecurity in clinical care settings, but patients differ in the support needed to reduce food insecurity and health systems have limited resources to invest in these interventions. Rat... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Food Insecurity, Pregnancy
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Designing a Virtual Reality Intervention to Improve Physical and Psychological Health in Intensive Care Units
NCT06797895
Recruiting
The goal of this study is to explore if Virtual Reality helps patients in the cardiothoracic ICU move more and feel better. Participants will be asked to answer a survey about anxiety, depression, and loneliness. The study team will teach participants how to use the VR device and how to play the game. Participants will play the game at least once per day, but can play as much as they want. Study activities include nurse facilitated patient use of VR applications that involve upper body movement... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: Duke University Hospital, Durham, North Carolina
Conditions: Mobility, ICU, Heart Surgery, Nursing
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Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial
NCT06601933
Recruiting
Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be superior to computerized cognitive training on the primary cognitive outcome and function with decreased brain atrophy. Building on these findings, this study will evaluate and compare the impact of high d... Read More
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
06/26/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Mild Cognitive Impairment (MCI), Cognitive Training
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QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer
NCT06551116
Recruiting
This study will assess whether a quantitative, HER2 assay can accurately and reliably discriminate between responders and non-responders among patients with HER2 IHCI+ metastatic breast cancer who are receiving T-Dxd.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: UNC Chapel Hill, Chapel Hill, North Carolina
Conditions: HER2-positive Metastatic Breast Cancer
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Role of Aging and Individual Variation in Exercise Training Responsiveness
NCT06471569
Recruiting
The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15 years (Parent trial: STRRIDE-PD; NCT00962962). This feasibility pilot study will enroll up to 8 participants to complete a 6-month aerobic exercise intervention.
Gender:
ALL
Ages:
Between 60 years and 90 years
Trial Updated:
06/26/2025
Locations: Duke Center for Living, Durham, North Carolina
Conditions: Prediabetic State, Cardiovascular Diseases, Insulin Resistance, Obesity
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