North Carolina is currently home to 2646 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors
NCT05135559
Recruiting
This study will test how well a new medicine called concizumab works for participants who have haemophilia A or B with or without inhibitors. The purpose is to show that concizumab can prevent bleeds and is safe to use. Participants will have to inject the study medicine every day under the skin with a pen-injector. The study will last for at least 2 years and up to about 4 years. The length of time the participant will be in the study depends on if the study medicine will be available for pur... Read More
Gender:
ALL
Ages:
All
Trial Updated:
06/19/2025
Locations: ECU Sickle Cell Comp Clinic, Greenville, North Carolina
Conditions: Haemophilia A and B With and Without Inhibitors
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Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127)
NCT04665037
Recruiting
This study aims to estimate the pharmacokinetics (PK) of posaconazole (POS, MK-5592) intravenous (IV) and powder for oral suspension (PFS) formulations in pediatric participants \<2 years of age with invasive fungal infection (IFI).
Gender:
ALL
Ages:
Between 1 day and 2 years
Trial Updated:
06/19/2025
Locations: Duke University Medical Center ( Site 2106), Durham, North Carolina
Conditions: Invasive Fungal Infection
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Study of Zifibancimig in Participants With Neovascular Age-Related Macular Degeneration
NCT04567303
Recruiting
This is a first in-human study to investigate the safety, tolerability and efficacy of zifibancimig administered through intravitreal (IVT) injections and via the Port Delivery (PD) implant in participants with neovascular age-related macular degeneration (nAMD)
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/19/2025
Locations: Graystone Eye, Hickory, North Carolina
Conditions: Macular Degeneration
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A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy
NCT04015141
Recruiting
The purpose of the study is to evaluate the efficacy of perampanel as measured by the 50 percent (%) responder rate during the maintenance period of the core study for seizure frequency in participants with pediatric epileptic syndrome (Cohort 1) and partial-onset seizures (POS) (Cohort 2).
Gender:
ALL
Ages:
Between 1 month and 18 years
Trial Updated:
06/19/2025
Locations: Wake Forest Baptist Medical Center - PPDS, Winston-Salem, North Carolina
Conditions: Pediatric Epileptic Syndrome, Partial-onset Seizures
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Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
NCT03876054
Recruiting
The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's neurostimulation systems.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: Premier Pain Solutions, Asheville, North Carolina
Conditions: Chronic Pain
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Stress Trajectories and Anhedonia in Adolescence Research Study
NCT07040449
Recruiting
This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence. The goal of this project is to see if it is possible to combine these biological measures to describe different patterns of activity in the brain and body that adolescents may have in response to stress. The main question this study aims to answer is whether different patterns of activity in the brain and body are related... Read More
Gender:
ALL
Ages:
Between 13 years and 15 years
Trial Updated:
06/18/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Anhedonia, Stress Response, Adolescent Development
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Photon-counting CT in Chest Imaging
NCT07031336
Recruiting
Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects. The goal is to establish acquisition protocols for PCCT scans with proper post-processing (e.g., reconstruction parameters and harmonization techniques) that enable reproducible measurements of emphysema metrics (e.g., Perc15, LAA-950, HU accuracy) and airways (Pi10, WA%) in the lungs. Study activities and population group: The study will recruit subject... Read More
Gender:
ALL
Ages:
All
Trial Updated:
06/18/2025
Locations: Duke University Hospital, Durham, North Carolina
Conditions: COPD (Chronic Obstructive Pulmonary Disease)
Register for Updates
Olfactory Biopsies
NCT07021040
Recruiting
This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell. The purpose of this study is to collect tissue from the nasal cavity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2025
Locations: Duke University Health Center, Durham, North Carolina
Conditions: Alzheimer Disease, Smell Loss, Smell Dysfunction
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Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)
NCT07014176
Recruiting
The purpose of this study is to determine how well our dHPT (Dehydrated Human Placental Tissue) Product and Standard of Care work when compared to Standard of Care alone in achieving complete closure of diabetic foot.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2025
Locations: 002, Rocky Mount, North Carolina
Conditions: Diabetic Foot Ulcer
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Emergency Medical Services (EMS) Telehealth to Speed STEMI Reperfusion
NCT06945900
Recruiting
The aim of this study is to evaluate the impact of a Telehealth program on the time from First Medical Contact (FMC) to Reperfusion in STEMI (ST-elevation myocardial infarction) patients, by supporting local paramedics in their care delivery.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
06/18/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: STEMI - ST Elevation Myocardial Infarction
Register for Updates
A Study to Learn About How the Flu and COVID-19 Vaccines Act in Healthy People
NCT06821061
Recruiting
The purpose of this study is to learn about how the flu and COVID vaccines act when given alone or when mixed together. This study is seeking healthy participants aged 18 or older. All participants in this study will receive only 1 shot to their arm, either a flu or COVID vaccine, alone or mixed. Participants will take part in this study for about 6 months, and participants will need to visit the clinical study site at least 4 times.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2025
Locations: Trial Management Associates - Wilmington - Floral Parkway, Wilmington, North Carolina
Conditions: Influenza, COVID-19 (Coronavirus Disease 2019)
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Effectiveness of a Cloud-based Digital Health Navigation Program for Colorectal Cancer Screening
NCT06821009
Recruiting
mPATH-CRC (mobile Patient Technology for Health) is an automated direct-to-patient digital health program about colorectal cancer screening. The goal of this project is to test a cloud-based version of mPATH that patients can use at home independent of a scheduled medical visit. Patients will access mPATH on their own devices using a hyperlink sent via text message. The cloud version of mPATH will have the proven effective content of the tablet version, including the ability to request a screeni... Read More
Gender:
ALL
Ages:
Between 45 years and 74 years
Trial Updated:
06/18/2025
Locations: Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina
Conditions: Colorectal Cancer Screening
Register for Updates