There are currently 1270 clinical trials in Cleveland, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Cleveland Clinic, Cleveland Clinic Foundation, Case Western Reserve University and University Hospitals Cleveland Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL
NCT04260022
Recruiting
A multi-center, open-label, randomized, phase Ib study to evaluate the pharmacokinetics (PK) of HQP1351 and to determine the recommended phase 2 dose (RP2D) of HQP1351 in subjects with CML chronic phase (CP), accelerated phase (AP), or blast phase (BP) or with Ph+ ALL, who have experienced resistance or intolerance to at least two tyrosine kinase inhibitors (TKIs) or in subjects with Ph+ B-cell precursor (BCP) ALL or lymphoid blast phase CML (CML LBP), who have experienced resistance or intolera... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2023
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Leukemia, Myeloid, Chronic, Myeloid Leukemia, Chronic Myeloid Leukemia, Philadelphia Positive Acute Lymphoblastic Leukemia, B Cell Precursor Type Acute Leukemia
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Everglade Stem, World Cup and World Liner Post Market Clinical Follow-up
NCT06153940
Recruiting
The aim of the Study is to monitor the performance of the Signature Orthopaedics Everglade Stem, World Acetabular Cup and World Liner as a part of post-market vigilance and continuous improvement efforts.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/22/2023
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Hip Disease
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Electrical Stimulation for Continence After Spinal Cord Injury
NCT02978638
Recruiting
This study aims to improve continence and voiding of patients with spinal cord injury using electrical stimulation. The Finetech Vocare Bladder System is an implantable sacral nerve stimulator for improving bladder and bowel function in patients with spinal cord injury (SCI). It has been commercially available in Britain and other countries since 1982, and has been used in thousands of patients with SCI to improve bladder, bowel and sexual function. It received FDA approval in 1998 under Humani... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
11/01/2023
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Spinal Cord Injury, Neurogenic Bladder, Incontinence
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APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma
NCT04942067
Recruiting
This is a Phase Ib/II, open-label, multi-center study evaluating the safety, tolerability, efficacy, and PK/ Pharmacodynamics of APG-2575 in combination with Pd/DRd in patients with relapsed/refractory (RR) multiple myeloma (MM). The study consists of dose escalation and dose expansion phases. The study consists of will start with 2 arms noted below, both arms are independent
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Cleveland Clinic Hosptials, Cleveland, Ohio
Conditions: Multiple Myeloma, Amyloidosis
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PRagmatic EVAluation of a Quality Improvement Program for People Living With Modifiable High-risk COPD.
NCT05306743
Recruiting
A 3-year cluster randomized controlled trial of the impact of a quality improvement and clinical decision support package versus usual care for patients with modifiable high-risk chronic obstructive pulmonary disease with or without a current diagnosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2023
Locations: MetroHealth, Cleveland, Ohio
Conditions: Chronic Obstructive Pulmonary Disease
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Accuracy of Pulse Oximeters With Profound Hypoxia
NCT06022523
Recruiting
The goal of this clinical trial is the acquisition of photoplethysmography signals during periods of profound hypoxia. The study is designed in accordance with ISO 80601- 2-61,2ed:2017-12 \& 2018-02.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/30/2023
Locations: Consolidated Research, Inc., Cleveland, Ohio
Conditions: Hypoxemia
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Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
NCT05919342
Recruiting
This is an international prospective, multicentre, unblinded, randomised-controlled trial. The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure in high-risk patients.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/02/2023
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Heart Failure, Cardiovascular Diseases
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CPAP Adherence Pilot Study Among African Americans
NCT05955287
Recruiting
The goal of the study is to determine the feasibility of a behavioral intervention to improve CPAP adherence among African American patients with obstructive sleep apnea.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/12/2023
Locations: MetroHealth Medical System, Cleveland, Ohio
Conditions: Sleep Apnea
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An All Comers Registry For Normothermic Ex Vivo Lung Perfusion (EVLP) as Assessment of Donor Lungs for Transplant
NCT05101460
Recruiting
The XVIVO Registry is to collect standard of care clinical data from "all-comers" who are transplanted with an EVLP lung treated with the XVIVO Perfusion System™ in order to assess the long-term performance of the device, and monitor device-related serious adverse events. In addition, 4 and 5-year UNOS registry data of the 126 subjects who received an EVLP transplant under the NOVEL and NOVEL Extension studies are provided as part of the long-term safety and quality of life data. In addition, 4... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2023
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Lung Transplant
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Magnetocardiography as a Noninvasive Diagnostic Strategy for Identifying Coronary Allograft Vasculopathy
NCT05751915
Recruiting
Purpose: To show early feasibility of magnetocardiography (MCG) to identify coronary Cardiac positron emission tomography (PET) is the preferred non-invasive tests to assess for CAV and incorporation of quantitative myocardial blood flow (MBF) assessment improves diagnostic accuracy. Based on ISHLT criteria, the following have been proposed for diagnosis of CAV by PET:
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2023
Locations: The Cleveland Clinic, Cleveland, Ohio
Conditions: Coronary Allograft Vasculopathy (CAV)
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Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
NCT05291884
Recruiting
This is a prospective, multi-center, single-arm, early feasibility study that aims to evaluate the safety of the Impella BTR™ in adult patients requiring left-ventricular hemodynamic support, and to evaluate the effectiveness of the Impella BTR™ in supporting patients to recovery or their next therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/07/2023
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Heart Failure, Acute Decompensated Heart Failure
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CERENOVUS Neurothrombectomy Devices Registry
NCT05591183
Recruiting
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Cerebral Stroke
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