There are currently 1271 clinical trials in Cleveland, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Cleveland Clinic, Cleveland Clinic Foundation, Case Western Reserve University and University Hospitals Cleveland Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Promoting Access, Resources and Treatment Through Novel and Equitable Solutions for Cancer Care
NCT06481774
Recruiting
The purpose of this research is to evaluate a novel, integrated approach to providing navigation services to improve cancer outcomes and quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Cancer
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Preoperative Weight Loss for Open Abdominal Wall Reconstruction
NCT05925959
Recruiting
The goal of this randomized controlled trial is to compare preoperative intensive weight management to upfront surgery in obese patients undergoing complex abdominal wall reconstruction. The main question is will abdominal wall specific quality of life (using the HerQLes survey) for the group undergoing upfront surgery be non-inferior compared to the group in the weight management program.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: Cleveland Clinic Main Campus, Cleveland, Ohio
Conditions: Abdominal Wall Hernia
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Consent for Use of Stored Patient Specimens for Future Testing
NCT00031408
Recruiting
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing.
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2024
Locations: Cleveland Clinic (A2508), Cleveland, Ohio +1 locations
Conditions: HIV Infections
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Neuroblastoma Maintenance Therapy Trial
NCT02679144
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, single agent, multicenter, study for patients with neuroblastoma in remission. In this study subjects will receive 730 Days of oral difluoromethylornithine (DFMO) at a dose of 750 mg/m2 ± 250 mg/m2 BID (strata 1, 2, 3, and 4) OR 2500 mg/m2 BID (stratum 1B) on each day of study. This study will focus on the use of DFMO in high risk neuroblastoma patients that are in remission as a strategy to prevent recurrence.
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
09/18/2024
Locations: Cleveland Clinic Children's, Cleveland, Ohio
Conditions: Neuroblastoma
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CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease)
NCT04748861
Recruiting
The overall goal of the CYCLE-AD trial is to determine the role of long-term, high intensity exercise in slowing or delaying the onset of cognitive and AD-related brain changes in e4 carriers. Successful translation and demonstration of the effectiveness of a scalable home-based exercise intervention capable of slowing or delaying disease onset will transform AD treatment, improve patient outcomes and quality of life, and reduce health care costs.
Gender:
ALL
Ages:
Between 65 years and 80 years
Trial Updated:
09/17/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: High Intensity Exercise, Normal Cognition, Exercise Intervention
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Study of SGR-2921 in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
NCT05961839
Recruiting
The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) and/or recommended dose (RD) of SGR-2921.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/13/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Acute Myeloid Leukemia, High-Risk and Very High-Risk Myelodysplastic Syndromes
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Mesh Removal Versus No Mesh Removal for Chronic Groin Pain After Inguinal Hernia Repair
NCT05484635
Recruiting
This study is evaluating the management of chronic post-operative inguinal hernia pain and the impact of hernia mesh removal after previous minimally invasive inguinal hernia repairs. The study aims are to evaluate the change in chronic (\>6 months), nociceptive, postoperative inguinal pain after mesh removal compared to no mesh removal in patients who have previously undergone minimally invasive inguinal hernia repair with pre-peritoneal mesh.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Chronic Groin Pain, Hernia, Inguinal
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Suture Repair vs Mesh Repair for Incisional Hernia
NCT05599750
Recruiting
The goal of this randomized controlled trial is to compare the difference in quality of life at one year postoperatively for patients undergoing incisional hernia repair with mesh versus suture repair using modern techniques. The main question it aims to answer are: • Determine if primary suture repair is non-inferior to mesh repair for incisional hernias 2-6cm with respect to quality of life using the HerQLes summary score at one year postoperatively.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2024
Locations: Cleveland Clinic Main Campus, Cleveland, Ohio
Conditions: Incisional Hernia
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Mesh Vs Pledgets for Repair of Paraesophageal Hernia
NCT05974722
Recruiting
The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are: * Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair. * Assess patient quality of life (QOL) after paraes... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2024
Locations: Cleveland Clinic Center for Abdominal Core Health, Cleveland, Ohio
Conditions: Paraesophageal Hernia, GERD
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T Cell Therapy of Opportunistic Cytomegalovirus Infection
NCT02982902
Recruiting
The purpose of this study is to determine if a specific type of cell-based immunotherapy, using T-cells from a donor that are specific against cytomegalovirus (CMV) is feasible to treat infections by CMV. Adoptive T-cell therapy is an investigational (experimental) therapy that works by using the blood of a donor and selecting the T-cells that can respond against a specific infectious entity. These selected T-cells are then infused to the patient, to try to give the immune system the ability to... Read More
Gender:
ALL
Ages:
3 months and above
Trial Updated:
09/09/2024
Locations: University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Cytomegalovirus Infections, Hematopoietic Stem Cell Transplant, Opportunistic Infections
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Phenotypic Classification of FMR With CMR
NCT05965258
Recruiting
The goal of the current research is to develop personalized risk prediction for functional mitral regurgitation (FMR) patients through explainable unsupervised phenomapping enriched with advanced cardiac magnetic resonance (CMR) imaging biomarkers, and to determine the CMR predictors of reverse remodeling following modern therapies for FMR. The prospective study entails aiming to recruit 360 adult patients (ages \>18 years) with EF 10-50% and FMR RF\> 20%, who are clinically referred for CMR ev... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Nonischemic Congestive Cardiomyopathy, Functional Mitral Regurgitation, Ischemic Cardiomyopathy
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Intracardiac Echocardiography Guided Watchman Device Implant
NCT06007872
Recruiting
This study is to look at the success of Intracardiac Echocardiography (ICE) in the Watchman procedure. Currently the process is to use a Transesophageal Echocardiography (TEE) to place the Watchman in patients. This study is aiming to show how the ICE is just as effective in placing the device correctly and effectively.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Atrial Fibrillation, Left Atrial Appendage Thrombosis
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