There are currently 1278 clinical trials in Cleveland, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Cleveland Clinic, Cleveland Clinic Foundation, Case Western Reserve University and University Hospitals Cleveland Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Project 3: ACHIEVE- CHD
NCT05918380
Recruiting
This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health Inequities by Early PreVEntion in the GREAT LakEs Region) Center (IRB 100221MP2A), the purpose of which is to reduce cardiometabolic health disparities and downstream Black-White lifespan inequality in two cities: Detroit, Michigan, and Cleveland, Ohio. The ACHIEVE GREATER Center will involve three separate but related projects that aim to mitigate health disparities in risk factor control for three chronic conditions... Read More
Gender:
ALL
Ages:
Between 40 years and 75 years
Trial Updated:
06/19/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Coronary Heart Disease
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A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT02817633
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: GSK Investigational Site, Cleveland, Ohio
Conditions: Neoplasms
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An Early Feasibility Study of the ReHAB System
NCT03898804
Recruiting
The purpose of this research study is to examine the feasibility of a system that involves implanting small electrodes in the parts of the brain that control movement and sensation, and combining that with electrodes in the upper arm and shoulder to activate paralyzed muscles of the arm and hand. This system is intended for people with extensive paralysis in their arms. The small electrodes in the brain will be used to attempt to measure intended movements, and the muscles in the arm and hand wi... Read More
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
06/18/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Tetraplegia
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Preoperative (Pre-amputation) Cryoanalgesia to Improve Post-amputation Phantom Limb Pain
NCT06284109
Recruiting
Investigators will evaluate preamputation cryoanalgesia on pain, mobility, opioid use and general physical and emotional disability using a pilot randomized trial design, to explore the amount and variability of improvement on those outcomes and to investigate the potentiality of conducting a future larger randomized controlled trial, which the investigators will assess quantitatively the benefits of cryoanalgesia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Postoperative Pain
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Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)
NCT04978636
Recruiting
This is a multi-institutional study (CCF, UPMC, OSU) evaluating different ventilation strategies during cardiopulmonary bypass on mortality and postoperative pulmonary complications, with sub-study investigating 8-iso-prostaglandin F2a and sRAGE levels.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Cardiac Surgery
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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
NCT04262206
Recruiting
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Gender:
ALL
Ages:
75 years and above
Trial Updated:
06/14/2024
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
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Feasibility of Early Gabapentin as an Intervention for Neurorecovery
NCT05302999
Recruiting
The objective of the proposed study is to conduct the first ever prospective, dose-exploration trial to test the feasibility of early administration of gabapentin as an intervention for neurorecovery. This research project falls under the Intervention Development stage of research as the primary goal is to assess the feasibility of conducting a well-designed intervention efficacy study in the future.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Spinal Cord Injuries
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Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy
NCT04310241
Recruiting
Amblyopia and strabismus are characterized by a reduction in visual acuity, contrast sensitivity, grating acuity, vernier acuity, reading difficulties and binocular visual function deficits. Treated patients have residual visual function deficits. The purpose of the current study is to quantify various visual functions in amblyopic and strabismic participants at baseline, during and at the completion of treatment.
Gender:
ALL
Ages:
Between 6 months and 90 years
Trial Updated:
06/10/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Amblyopia, Strabismus
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Low Voltage-Directed Catheter Ablation for Atrial Fibrillation
NCT03355456
Recruiting
A two-pronged approach to evaluate long term success of non-paroxysmal ablation when using a: 1. specified low voltage-directed with pulmonary vein isolation (LD+PVI) approach compared to , 2. an approach of pulmonary vein isolation (PVI) alone.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
06/07/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Atrial Fibrillation - Symptomatic
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Creating a Healthy L.I.F.E: Lifestyle Interventions For Epilepsy
NCT05283200
Recruiting
A prospective controlled, randomized study to examine the effects of behavioral and wellness-based interventions on seizure frequency for adult patients with medication resistant epilepsy who are still experiencing 1 or more seizures per month.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/07/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Lifestyle
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Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)
NCT04069312
Recruiting
A multi-center, randomized, 72-month, parallel- group, non-inferiority, phase III study to compare the effectiveness of roflumilast (Daliresp, 500 mcg quaque die (QD) or alternate regimen) therapy versus azithromycin (250 mg QD, 500 mg QD three times per week, or alternate regimen) to prevent hospitalization or death in a patients at high risk for COPD exacerbations.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
06/06/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio +1 locations
Conditions: Chronic Obstructive Pulmonary Disease Severe, Chronic Bronchitis
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DNA Evaluation of Fragments for Early Interception - Lung Cancer Training Study (DELFI-L101 Study)
NCT04825834
Recruiting
The primary objective of this study, DELFI-L101, is to train and test classifiers for lung cancer detection using the DELFI assay and other biomarker and clinical features.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/05/2024
Locations: The Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Lung Cancer, Head and Neck Cancer, Esophageal Cancer, Bladder Cancer, Kidney Cancer, Stomach Cancer, Colorectal Cancer, Pancreas Cancer, Liver Cancer, Skin Cancer
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