Ohio is currently home to 3309 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of Ossium Mesenchymal Stem Cells for the Treatment of Pouch Fistulas in the Setting of Crohn's Disease
NCT05075811
Recruiting
The purpose of this study is to determine the safety and feasibility of using Ossium vertebral Bone Marrow Derived Mesenchymal Stem Cells (vBM-MSC) to treat people with an ileal pouch anal anastomosis (IPAA) who develop a fistula in the setting of Crohn's disease of the pouch.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/01/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Pouch, Ileal, Fistula
Register for Updates
Study of Mesenchymal Stem Cells for Pediatric Perianal Fistulizing Crohn's Disease
NCT04791878
Recruiting
This study plans to enroll 10 patients aged 13-17 years of age with refractory perianal fistulizing disease. Patients will be treated by direct injection to the fistula tract(s) with 75 million allogeneic bone marrow derived mesenchymal stem cells at baseline and again after 3 months if not completely healed.
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
04/01/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Perianal Fistula Due to Crohn's Disease (Disorder)
Register for Updates
MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)
NCT04578392
Recruiting
Study description - Patients will be randomized according to post-operative recurrence risk to either a high ligation of ileocolic artery or mesenteric sparing ileocolic resection for terminal ileal Crohn's disease. The primary endpoint 6-month endoscopic recurrence. Endpoints - Primary endpoint; 6 months Secondary endpoints at 1 and 5 years post ileocecal resection Study population - Adult Crohn's disease patients with medically refractory terminal ileal Crohn's disease undergoing a primary i... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/01/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Crohn Disease
Register for Updates
Mesenchymal Stem Cells for the Treatment of Perianal Fistulizing Crohn's Disease
NCT04519671
Recruiting
The purpose of this study is to determine the safety and efficacy of using adult allogeneic bone marrow derived mesenchymal stem cells (MSCs), to treat people for medically refractory perianal fistulizing Crohn's disease.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/01/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Perianal Crohn Disease, Perianal Fistula, Crohn Disease
Register for Updates
Study of Mesenchymal Stem Cells for the Treatment of Ileal Pouch Fistula's in Participants With Crohn's Disease
NCT04519684
Recruiting
Restorative proctocolectomy with ileal pouch anal anastomosis (IPAA) is the procedure of choice for patients with ulcerative colitis, familial adenomatous polyposis, and select patients with Crohn's disease due to overall low patient morbidity and good quality of life. However, some patients can develop Crohn's disease of the pouch, a clinical diagnosis of Crohn's disease following IPAA. One of the manifestations of Crohn's disease of the pouch includes a fistula from the pouch that travels to t... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/01/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Ileal Pouch, Crohn Disease
Register for Updates
Mesenchymal Stem Cells for the Treatment of Rectovaginal Fistulas in Participants With Crohn's Disease
NCT04519697
Recruiting
Approximately 10% of all female Crohn's patients have a rectovaginal fistula. Rectovaginal fistulas cause air, stool, and/or drainage per vagina and may be associated with pain, recurrent urinary tract infections and diminished quality of life. Conventional therapy includes immunosuppressive medications used to treat Crohn's disease and various surgical interventions. However, all have limited ability to heal these fistulas. The purpose of this study is to determine the safety and efficacy of us... Read More
Gender:
Female
Ages:
Between 18 years and 75 years
Trial Updated:
04/01/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Rectovaginal Fistula, Crohn Disease, Crohn Disease of Vulva, Rectolabial; Fistula
Register for Updates
Genetics of QT Prolongation With Antiarrhythmics
NCT02439658
Recruiting
To assess the ability of common genetic variants in aggregate to predict drug-induced QT prolongation in patients being loaded with dofetilide or sotalol.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/25/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Long QT Syndrome, Drug Toxicity
Register for Updates
Study to Evaluate the Pharmacodynamics and Efficacy of Leuprolide Tablets (Ovarest®) in Women With Endometriosis
NCT05096065
Recruiting
The pharmacodynamic endpoint of percentage of subjects with suppressed estradiol level (less than 20 pg/mL) on cycle day 29 is the primary endpoint of the study.
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
03/21/2022
Locations: Complete Healthcare for Women, Columbus, Ohio
Conditions: Endometriosis
Register for Updates
Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid Tumors
NCT02013336
Recruiting
This is a Phase 1 study of the combination of two drugs: MM-398 and Cyclophosphamide. The goal is to find the highest dose of MM-398 that can be given safely when it is used together with the chemotherapy drug Cyclophosphamide.
Gender:
All
Ages:
Between 12 months and 20 years
Trial Updated:
03/17/2022
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Recurrent or Refractory Solid Tumors, Ewing Sarcoma, Rhabdomyosarcoma, Neuroblastoma, Osteosarcoma
Register for Updates
A Study of Autonomic Dynamic Dysfunction to Predict Infections After Spinal Cord Injury.
NCT03253952
Recruiting
The study is designed to investigate whether autonomic shifts (dysautonomia, sympatho-vagal instability) that develop after SCI have value in predicting SCI-associated infections (SCI-AI). SCI-AI impair outcomes by (1) reducing the intrinsic neurological recovery potential and (2) increasing mortality. Heart Rate Variability (HRV) data will be tracked in both the time and frequency domains to discriminate between the relative contribution of sympathetic and parasympathetic innervation to changes... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2022
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Trauma, Spinal Cord, SPINAL Fracture
Register for Updates
Prospective Global Registry for the Study of Chronic Total Occlusion Intervention
NCT02061436
Recruiting
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes of consecutive patients undergoing CTO PCI among various participating centers. The information collected will be used to deter... Read More
Gender:
All
Ages:
All
Trial Updated:
03/08/2022
Locations: The Christ Hospital Ohio Heart & Vascular, Cincinnati, Ohio
Conditions: Coronary Artery Disease
Register for Updates
Usefulness of Video-Based Intervention in Helping Participants Encourage Their Families to Get Tested for BRCA Gene Mutations
NCT05264532
Recruiting
This trial studies how well a video-based intervention works in helping participants encourage their families to get tested for BRCA gene mutations. Testing in families with BRCA gene mutations can allow for risk management and reduction with the overall goal of reducing cancer burden. Video-based intervention sent via text messages may help participants easily share information about BRCA gene mutations with family members.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/02/2022
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: BRCA1 Gene Mutation, BRCA2 Gene Mutation
Register for Updates