Ohio is currently home to 3328 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Evaluating the Experience of Upper Limb Prosthesis Use
NCT04855214
Recruiting
Our goal is to understand the critical factors associated with outcome acceptance following upper limb loss. We aim to develop a unified theoretical model that describes the psychosocial experience of upper limb prosthesis use and predicts outcome acceptance following upper limb loss. This conceptual framework will enable clinicians and researchers to evaluate and predict patient outcomes following limb loss, and to design interventions that improve outcomes. The proposed two-year study is a mix... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2021
Locations: Louis Stokes VA Medical Center, Cleveland, Ohio
Conditions: Prosthesis User, Amputation, Upper Limb Amputation at the Wrist, Upper Limb Amputation Above Elbow (Injury), Upper Limb Amputation Below Elbow (Injury)
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Belatacept With Early Steroid Withdrawal rATG and Everolimus in Renal Transplantation (BETTER Trial)
NCT04849533
Recruiting
This study is designed to determine the safety and efficacy of two calcineurin inhibitor free treatment groups 1) a belatacept, everolimus and early corticosteroid withdrawal (ECSWD) immunosuppressive regimen with rabbit antithymocyte globulin induction (rATG) and 2) a belatacept, mycophenolate, chronic steroid regimen with rATG and compare to historical controls of tacrolimus-based and belatacept-based regimens in combination with rATG induction, mycophenolate, and ESWD in renal transplant reci... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/14/2021
Locations: The Christ Hospital, Cincinnati, Ohio
Conditions: Kidney Transplant Rejection
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Adjuvant Hypofractionated Whole Pelvis Radiation Therapy in Endometrial Cancer
NCT04458402
Recruiting
Studying adjuvant hypofractionated whole pelvis radiation therapy in Endometrial Cancer.
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/09/2021
Locations: University of Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Endometrial Cancer
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An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04718818
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Beachwood, Ohio
Conditions: Ulcerative Colitis
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The Impact of Human Milk Oligosaccharide 2'-Fucosyllactose
NCT04718662
Recruiting
This is a double blinded, randomized, controlled trial of 2'-Fucosyllactose in infants born between 29 and 32 weeks gestational age. The investigators anticipate enrollment of 90 subjects in total and for the study to be completed in 18 months. The investigators anticipate collecting clinical data, anthropometrics, stool samples (requiring appropriate storage through analysis), salivary samples from mother and infant, discarded blood samples from baby after the standard care lab tests are done,... Read More
Gender:
All
Ages:
10 days and below
Trial Updated:
01/19/2021
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Premature Birth
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Testing an Active Form of Tamoxifen (4-hydroxytamoxifen) Delivered Through the Breast Skin to Control Ductal Carcinoma in Situ (DCIS) of the Breast
NCT02993159
Recruiting
This randomized phase IIB trial studies how well tamoxifen or afimoxifene works in treating patients with estrogen receptor positive breast cancer. Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate or afimoxifene may fight breast cancer by blocking the use of estrogen by the tumor cells.
Gender:
Female
Ages:
18 years and above
Trial Updated:
12/17/2020
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Ductal Breast Carcinoma In Situ, Estrogen Receptor Positive
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Vitamin D and Photodynamic Therapy for Treatment of BCC in BCNS
NCT03483441
Recruiting
The purpose of this research is to evaluate the use of Photodynamic Therapy (PDT) to treat the multiple basal cell carcinoma (BCC) skin cancers in children and adults with Basal Cell Nevus Syndrome (or who have at least 3 BCC tumors present). In addition, the investigators will test a hypothesis (based upon our extensive preclinical studies in mice) that induction of a transient spike in serum Vitamin D levels through administration of dietary Vitamin D (cholecalciferol; D3) can significantly in... Read More
Gender:
All
Ages:
All
Trial Updated:
11/19/2020
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Basal Cell Nevus Syndrome, Basal Cell Carcinoma
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Four-Way Crossover Study to Compare Ferric Maltol Capsules and Oral Suspension in Healthy Volunteers
NCT04626414
Recruiting
The purpose of the study is to compare the Pharmacokinetics (PK) of the new ferric maltol suspension, in adults, with the existing ferric maltol capsule.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
11/06/2020
Locations: Medpace Clinical Pharmacology Unit, Cincinnati, Ohio
Conditions: Anemia, Iron Deficiency
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Temsirolimus Alone or Paired With Dexamethasone Delivered to the Adventitia to eNhance Clinical Efficacy After Femoropopliteal Revascularization
NCT03942601
Recruiting
This is a prospective, multi-center, pilot feasibility study to document the effects of adventitial delivery of temsirolimus or temsirolimus with dexamethasone sodium phosphate injection, USP, after revascularization of femoropopliteal lesions in symptomatic patients with moderate to severe claudication (Rutherford 2-3) or critical limb ischemia (CLI) with rest pain (Rutherford 4). Subjects will be followed for up to 60 months post index procedure.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/31/2020
Locations: University Hospital, Cleveland, Ohio
Conditions: Peripheral Arterial Disease
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Clinical Trial Evaluating the Efficacy, Safety, and Tolerability of Cariprazine in a Dose-Reduction Paradigm in the Prevention of Relapse in Patients With Schizophrenia
NCT04519099
Recruiting
To evaluate the efficacy and safety of cariprazine at a target dose of 4.5 mg/d compared with placebo in prevention of relapse in patients with schizophrenia To evaluate the efficacy and safety of cariprazine at a target dose of 3.0 mg/d compared with placebo in prevention of relapse in patients with schizophrenia who were initially stabilized on a target dose of 4.5 mg/d
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
08/17/2020
Locations: Clinical Inquest Center Ltd, Beavercreek, Ohio
Conditions: Schizophrenia
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The Use of Indocyanine Green as a Diagnostic Adjunct for Pediatric Solid Malignancies
NCT04492735
Recruiting
Use of indocyanine green will augment the accuracy of identification and resection of both primary solid malignancies as well as their pulmonary metastases, where applicable We will conduct a prospective feasibility study of pediatric patients with solid malignancies with or without lung metastatases who present at the time of initial diagnosis or relapse. These patients will receive a targeted dye to aid in the resection of these metastases. We plan to assess ICG as it relates to: Diagnostic a... Read More
Gender:
All
Ages:
Between 1 day and 45 years
Trial Updated:
07/27/2020
Locations: Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio
Conditions: Metastatic Disease, Primary Tumor, Solid Malignancies
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Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratoses
NCT04482322
Recruiting
This is a prospective clinical trial in which 30 patients will receive a brief (5-day or 14-day) supplementation with 10,000 IU of Vitamin D, prior to receiving aminolevulinic acid (ALA)- blue light PDT for the treatment of actinic keratoses (AKs).
Gender:
All
Ages:
18 years and above
Trial Updated:
07/21/2020
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Actinic Keratoses
Register for Updates