Ohio Clinical Trials

A listing of Ohio Clinical Trials actively recruiting patient volunteers.

Every four years, Americans all around the country can can count on a deluge of news about Ohio, named for the Ohio River ("Good River") that runs through it. A state since 1803, it was the 17th state to join the union. Today, its major cities include Columbus, Cincinnati, Akron, and Cleveland, the latter still known for its rock and roll music. The state is inextricably intertwined with the history of aerospace, being home to the Wright Brothers and the birthplace of several early astronauts. Ohio's cities are served by a number of excellent hospitals, including Ohio Health Riverside Methodist Hospital.

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3393 trials found

A Study to Evaluate a Modified RNA Vaccine Against Influenza in Adults 18 Years of Age or Older

NCT05540522

This is a Phase 3, randomized, observer-blinded study to evaluate the efficacy, safety, tolerability, and immunogenicity of a single dose of a quadrivalent influenza modRNA vaccine compared to licensed inactivated influenza vaccine in healthy adults 18 years of age and older.

Conditions: Influenza, Human

A Study of ACR-368 in Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma

NCT05548296

This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with low dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status.

Conditions: Platinum-resistant Ovarian Cancer, Endometrial Adenocarcinoma, Urothelial Carcinoma
Phase: Phase 1/2

iPSC Repository of Pediatric Cardiovascular Disease

NCT05550324

Obtain blood samples for generation and maintenance of induced pluripotent stem cells (iPSCs) and genomic/DNA sequencing for biomedical research that will improve the understanding and treatment of pediatric cardiovascular disease

Conditions: Congenital Heart Disease, Heart Diseases

The Prevalence of Autoimmune Antibodies in Patients With Type 2 Diabetes Managed by Endocrinology vs. Primary Care

NCT05553145

The purpose of this study is to assess the levels of autoimmune markers of diabetes in those with a type 2 diabetes diagnosis.

Conditions: Type 2 Diabetes

Relapsed and Refractory Hepatoblastoma: A Prospective Registry and Liver Tumor Research Consortium Initiative

NCT05556642

There are limited data regarding the biology and treatment of relapsed/refractory hepatoblastoma (rrHBL). This project provides the infrastructure for acquisition of biological specimens, imaging, and correlative clinical data to facilitate biology studies and characterization of rrHBL. This registry will collect clinical, demographic, and pathological data, specimens (as available) and imaging from patients with rrHBL, prospectively. Cases are identified through: Existing clinical and/or cance ...

Conditions: Relapsed Hepatoblastoma, Refractory Hepatoblastoma

International CDKL5 Clinical Research Network

NCT05558371

Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome mea ...

Conditions: CDKL5, CDKL5 Deficiency Disorder, CDD

Development of an Informed Consent Statement Which Communicates the Risk of Adverse Events Associated With Dry Needling

NCT05560100

As Dry Needling (DN) continues to see increased use in the clinic, there is a need to establish adverse events that could occur as a result of DN intervention. The adverse events are important to consider when an individual needs to make an informed decision regarding their care. It is important to consider how such information should be presented during the informed consent process to improve an individual's ability to make a sound decision regarding their own personal care.

Conditions: Dry Needling

Strategies for Coping With Negative Thoughts

NCT05566691

The primary objective of this study is to assess the impact of two strategies for coping with negative automatic thoughts (positive thinking and cognitive restructuring) on one's belief in negative thoughts and one's affect. Another main objective is to assess whether participating in a positive mood induction (versus no mood induction) prior to using one of the two coping strategies impacts belief in negative thoughts and affect. We will also explore the interaction between strategy condition a ...

Conditions: Depressive Symptoms, Anxiety, Negative Thinking
Phase: Not Applicable

A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older

NCT05566639

The purpose of this study is to evaluate the safety and efficacy of mRNA-1010 in preventing seasonal influenza in adults 50 years and older.

Conditions: Seasonal Influenza