Oklahoma is currently home to 859 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Oklahoma City, Tulsa, Norman and Edmond. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors
NCT05277051
Recruiting
This is a first time in-human (FTIH) study designed to investigate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of GSK4381562 in participants with select loco-regionally recurrent solid tumors or metastatic solid tumors where curative or standard treatment options have been exhausted.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: GSK Investigational Site, Oklahoma City, Oklahoma
Conditions: Neoplasms
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PDN Post Market, Multicenter, Prospective, Global Clinical Study
NCT05301816
Recruiting
The purpose of this post-market study is to evaluate the real-world experience of Nevro's Spinal Cord Stimulation (SCS) therapy in patients with chronic, intractable leg pain due to painful diabetic neuropathy (PDN). This is a multicenter, prospective, observational global study, that will partner diabetes management teams with pain physicians to provide an interdisciplinary treatment regimen for PDN patients. Outcomes will be assessed via standardized assessments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Clinical Investigations, LLC, Edmond, Oklahoma
Conditions: Diabetic Neuropathy, Painful
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Single Position Spine Surgery Registry
NCT04839783
Recruiting
The purpose of this study is to systematically, prospectively compare surgical fusion techniques for thoracolumbar spinal fusion patients and assess long-term patient outcomes and revision rates following surgery.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/01/2024
Locations: The Spine Clinic of Oklahoma City, Oklahoma City, Oklahoma
Conditions: Spine Fusion, Spinal Stenosis, Degenerative Disc Disease
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Ultra-Processed Foods and Executive Function
NCT06518863
Recruiting
The purpose of this study is to examine potential effects of a diet characterized by UPF on hunger-related hormones and executive function. It entails a two-arm, crossover, randomized controlled trial.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
10/31/2024
Locations: Oklahoma State University, Stillwater, Oklahoma
Conditions: Diet Habit
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Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa
NCT06332963
Recruiting
The proposed study utilizes a randomized experimental therapeutics design to test a mechanistic framework linking interoceptive processing and disturbed body image, with the purpose of informing the development of future therapies for body image dissatisfaction in anorexia nervosa (AN). A sample of 102 participants will be recruited from the Laureate Eating Disorder Program (LEDP). After being randomized, participants will all receive a one-hour session of acceptance- and mindfulness-based train... Read More
Gender:
FEMALE
Ages:
Between 15 years and 40 years
Trial Updated:
10/30/2024
Locations: Laureate Institute for Brain Research, Tulsa, Oklahoma
Conditions: Anorexia Nervosa, Body Image Disturbance, Interoception
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Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
NCT06004115
Recruiting
This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders. In a double blind, placebo controlled crossover design, up to 65 individuals will be recruited who will have a diagnosis of major depressive disorder (MDD) and at least one anxiety disorder (AD) (AD-MDD group), up to 65 participants will have a diagnosis of MDD and no diag... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/30/2024
Locations: Laureate Institute for Brain Research, Tulsa, Oklahoma
Conditions: Depression, Anxiety, Fear, Depression, Anxiety and Fear, Anxiety Disorders, Anxious Depression
Register for Updates
Substance Use Treatment and Access to Resources (STARS) Project
NCT04459000
Recruiting
This study is evaluating a randomized clinical trial and a quasi-experimental observational study combined. Pregnant women with substance abuse issues are referred to the Substance Use Treatment and Recovery (STAR) prenatal clinic, and those who consent to participate in the study will be randomized to the STAR + maternal Attachment Biobehavioral Catchup (mABC) home visiting model or to the STAR only treatment group. Those who opt out of receiving prenatal care at STAR will be recruited as a con... Read More
Gender:
ALL
Ages:
55 years and below
Trial Updated:
10/30/2024
Locations: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Substance Use Disorders, Pregnancy Related, Child Neglect
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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
NCT05929768
Recruiting
This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be bette... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Early Stage Triple-Negative Breast Carcinoma
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Study of ART6043 in Advanced/Metastatic Solid Tumors Patients
NCT05898399
Recruiting
This interventional study will evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of ART6043 as monotherapy or in combination with Olaparib or Niraparib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: Stephenson Cancer Center - Oncology, Oklahoma City, Oklahoma
Conditions: Advanced Solid Tumor, Metastatic Solid Tumor
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Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery
NCT06271265
Recruiting
This Phase 1, multicenter, open-label, randomized, bupivacaine-controlled study is designed to evaluate the pharmacokinetics (PK) and safety of EXPAREL vs. bupivacaine HCl for postsurgical analgesia in pediatric subjects aged 0 to less than 6 years of age undergoing cardiac surgery, utilizing local infiltration analgesia (LIA).
Gender:
ALL
Ages:
Between 0 years and 6 years
Trial Updated:
10/22/2024
Locations: University of Oklahoma (OU) - Medical Center - The Children's Hospital, Oklahoma City, Oklahoma
Conditions: Postoperative Pain
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Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD
NCT05566769
Recruiting
NMOSDCopilot is a digital tool developed for the self-assessment of Neuromyelitis Optica Spectrum Disorder symptoms that impact patients' functioning and quality of life. It has been co-designed with the help of patient advocacy groups, NMOSD patients and medical experts. It includes a smartphone-based application for patients, connected to a web portal developed for healthcare professionals (HCSPs). The patient application is composed of vision, walking, cognition, and dexterity e-active tests... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
Conditions: Neuromyelitis Optica
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tDCS for Post-Stroke Cognitive Impairment
NCT06516588
Recruiting
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in participants with post-stroke cognitive impairment (PSCI).
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
10/08/2024
Locations: University of Oklahoma, Oklahoma City, Oklahoma
Conditions: Stroke, Mild Cognitive Impairment
Register for Updates