Oklahoma is currently home to 859 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Oklahoma City, Tulsa, Norman and Edmond. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Digital Chest Tube Drainage System (Thopaz+) Versus Analog in Pediatric Patients
NCT05511987
Recruiting
In 2007 the Thopaz digital drainage system was launched as one of the first chest tube drainage systems to utilize a digital rather than analog device. The digital system allows for stored data, objective measurement of air leaks as well as maintaining a constant pleural pressure. The adult literature describes multiple benefits of using a digital drainage system, only two studies to date have looked at pediatric patients. In the adult literature, reported benefits include shorter chest tube dra... Read More
Gender:
ALL
Ages:
Between 0 minutes and 17 years
Trial Updated:
10/08/2024
Locations: University of Oklahoma, Oklahoma City, Oklahoma
Conditions: Air Leakage
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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
NCT03295981
Recruiting
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: University of Oklahoma, Oklahoma City, Oklahoma
Conditions: Giant Cell Tumor of Bone
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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
NCT05150691
Recruiting
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: University of Oklahoma, Oklahoma City, Oklahoma
Conditions: HER2-positive Advanced Solid Tumor
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Therapeutic Omegas for Triglyceride Suppression
NCT04349475
Recruiting
This study plans to learn more about how an omega-3 fatty acid supplement effects triglyceride levels in pregnancy. Triglycerides are a type of fat found in your blood. Your body converts extra calories into triglycerides to be stored and used later for energy. It is normal for triglyceride levels to go up during pregnancy however some women have levels that are \~30-40% higher than normal when they reach their third trimester of pregnancy. Having high triglycerides in pregnancy may be related t... Read More
Gender:
ALL
Ages:
Between 0 years and 39 years
Trial Updated:
10/02/2024
Locations: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Pregnancy
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IV Ensure in Patients Receiving OPAT
NCT06623318
Recruiting
The purpose of remote therapeutic monitoring is to provide oversight and evaluation of patients receiving IV medications in the home setting post-acute. The goal is to improve patient outcomes and decrease re-admission rates for related diagnoses due to poor adherence. Remote therapeutic monitoring provides data used in the determination of dates, times, and duration of doses administered in the home setting to support real-time intervention by dedicated care managers to support improved adheren... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/30/2024
Locations: The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Determine If Adherence Rates with IV Antibiotics in OPAT Have a Correlation to Hospital Readmission Rates
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Olorofim Aspergillus Infection Study
NCT05101187
Recruiting
The purpose of this study is to compare treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with IFD caused by proven IA or probable lower respiratory tract disease Aspergillus species (invasive aspergillosis, IA).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: OU Health OU Medical Center, Oklahoma City, Oklahoma
Conditions: Invasive Aspergillosis
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A Study to Check the Safety of Dexlansoprazole and Learn If it Can Heal Erosive Esophagitis (EE) and Keep it Healed in Children 2 to 11 Years Old
NCT02615184
Recruiting
Gastroesophageal reflux disease (GERD) is caused by food or acid coming up from the stomach into the esophagus, repeatedly. The esophagus is the tube that carries food and liquids from the mouth to the stomach. The body uses stomach acid to break down food, but when acid rises up into the esophagus it can hurt or damage it. People with GERD often feel food coming back up into the throat and mouth and have a burning feeling in their stomach, chest, or throat, called heartburn. Other symptoms of G... Read More
Gender:
ALL
Ages:
Between 2 years and 11 years
Trial Updated:
09/25/2024
Locations: Measurable Outcome Research, Oklahoma City, Oklahoma
Conditions: Erosive Esophagitis
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Non-invasive Vagal Stimulation for Frequent Premature Ventricular Complexes
NCT05341544
Recruiting
A prospective sham-controlled randomized clinical trial to assess the effect of low-level tragus stimulation (LLTS) in patients with frequent premature ventricular complexes (PVCs)
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/24/2024
Locations: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Premature Ventricular Contraction
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L-Citrulline and Endothelial Function
NCT05722860
Recruiting
The effect of L-Citrulline is well studied in relation to muscle strength, exhaustion, exercise performance, and endothelial function in health and disease. This study will extend current body of knowledge and will investigate the effect of L-Citrulline on brain vascular function.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
09/16/2024
Locations: Andriy Yabluchanskiy, Oklahoma City, Oklahoma
Conditions: Aging
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Myo-Inositol for Infertility in PCOS
NCT04407754
Recruiting
This will be a prospective, double-blind randomized clinical trial of letrozole and placebo versus letrozole and inositols for up to 5 treatment cycles of ovulation induction or until pregnancy is achieved. All participants and members of the research team will be blinded to the treatment arms. Placebo and inositol supplement will be packaged to appear the same, tested, and packaged by a commercial supply company. The inositols will be a 40:1 blend of myo-inositol and D-chiro inositol.
Gender:
ALL
Ages:
Between 18 years and 36 years
Trial Updated:
09/13/2024
Locations: OUHSC Reproductive Medicine Clinic, Oklahoma City, Oklahoma
Conditions: Polycystic Ovary Syndrome
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Artificial Intelligence to Measure Adherence to Oral Medication
NCT04046497
Recruiting
The aims of this project is to use an artificial intelligence (AI) smartphone app to provide support for medication adherence by patients with first episode psychosis.
Gender:
ALL
Ages:
Between 15 years and 40 years
Trial Updated:
09/10/2024
Locations: Red Rock, Oklahoma City, Oklahoma
Conditions: First Episode Psychosis
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Behavioral Activation + Occupational Therapy: An Innovative Intervention for Empowered Self-Management of Multiple Chronic Conditions
NCT05600465
Recruiting
Approximately 45% of older adults in the U.S. have 2 or more chronic health conditions (e.g., arthritis, hypertension, diabetes) in addition to functional limitations that prevent performance of health self-management activities. Self-management continues to be the gold standard for managing MCC, but functional limitations create difficulty with these activities (e.g., physical activity, symptom monitoring). Restricted self-management accelerates the downward spiral of disability and accumulatin... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
09/05/2024
Locations: OU Health Internal Medicine- Schusterman Clinic, Tulsa, Oklahoma
Conditions: Multiple Chronic Conditions, Disability Physical
Register for Updates