Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
NCT01484678
Recruiting
The purpose of this research study is to determine the potential of magnetic resonance imaging, spectroscopy, and whole body imaging to monitor disease progression and to serve as an objective outcome measure for clinical trials in Muscular Dystrophy (MD). The investigators will compare the muscles of ambulatory or non-ambulatory boys/men with DMD with muscles of healthy individuals of the same age and monitor disease progression in those with DMD over a 5-10 year period. The amount of muscle d... Read More
Gender:
MALE
Ages:
Between 5 years and 62 years
Trial Updated:
07/03/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
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Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)
NCT06963463
Recruiting
The goal of this clinical trial is to adapt a sleep intervention for individuals representative of all demographic groups, including those who are at the highest risk for suicidal behavior. Sleep difficulties are a promising target for youth with suicidal thoughts and behavior to focus on as a prevention measure. We aim to increase intervention acceptability and impact by adapting it for the adolescent populations at highest risk for suicidal thoughts and behavior. The research project will comp... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/02/2025
Locations: Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Sleep Disturbance, Sleep, Depression, Suicide
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TECTONIC CAD IVL IDE Study
NCT06885177
Recruiting
A prospective, single-arm, open-label, multi-center IDE study with up to 55 US sites
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Pinnacle Health System, Mechanicsburg, Pennsylvania
Conditions: Coronary Artery Calcification, Coronary Artery Disease, Stenotic Coronary Lesion
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Feasibility of Immersive Virtual Reality Dietician Program in Metabolic-dysfunction Associated Steatotic Liver Disease
NCT06215131
Recruiting
Metabolic-dysfunction associated steatotic liver disease, often referred to as "fatty liver disease", is a leading cause of liver failure. Dietary weight loss is a cornerstone of treating fatty liver disease, but access to traditional in-person nutritional education is often limited by cost, availability, and transportation. Immersive virtual reality (iVR) has the potential to not only overcome these barriers, but also provide an interactive learning experience, such as measuring and preparing f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Penn State College of Medicine, Hershey, Pennsylvania
Conditions: Fatty Liver, Nonalcoholic, Weight Loss, Virtual Reality, Implementation Science
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A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas
NCT06090539
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Local Institution - 0040, Pittsburgh, Pennsylvania
Conditions: Relapsed/Refractory Non-Hodgkin Lymphoma
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Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe
NCT05983757
Recruiting
A phase III, randomized, multi-center, investigational, open label clinical trial that will examine whether treatment with endovascular thrombectomy is superior to standard medical therapy alone in patients who suffer a Distal Medium Vessel Occlusion Ischemic Stroke within 12 hours from time last seen well
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Ischemic Stroke
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Post-Discharge Risk-Based Management in Patients Undergoing High-Risk Elective Major Cancer Operations (PRS II)
NCT05454280
Recruiting
This is a randomized trial of intensified post-discharge surveillance (Intervention Arm) versus standard post-discharge surveillance (Control Arm).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Fox Chase Cancer Center - Philadelphia, Philadelphia, Pennsylvania
Conditions: Surgery, Cancer
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Impact of Suture Type on Pigment Disturbances in Patients of Skin of Color
NCT05408117
Recruiting
The present study assesses if dissolvable (fast gut) or non-dissolvable (polypropylene) epidermal sutures produce better cosmetic results in terms of dyspigmentation and scarring in patients of skin of color. Through a split-wound study design, patients undergoing standard elliptical excisions at least 3 cm in length will receive each suture type. Measurements of dyspigmentation and scarring will be made at 7 days (for the head and neck), 10 days (for the trunk and extremities), and 3 months for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: UPMC Presbyterian, Pittsburgh, Pennsylvania
Conditions: Scar
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Role of the Immune Environment in Response to Therapy in Breast Cancer
NCT05396612
Recruiting
This is an observational case-control study of tissues collected from women with ER+HER2- breast cancers. The immune environments of these cancers will be compared to triple negative and HER2+ breast cancers. No randomization or changes to standard of care treatment will occur as part of the study.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Abramson Cancer Center, Philadelphia, Pennsylvania
Conditions: Breast Cancer, ER Positive Breast Cancer, HER2-negative Breast Cancer, TNBC - Triple-Negative Breast Cancer
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Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
NCT05267821
Recruiting
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).
Gender:
ALL
Ages:
Between 1 day and 17 years
Trial Updated:
07/02/2025
Locations: Pennsylvania State University, Hershey, Pennsylvania
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
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Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)
NCT04365374
Recruiting
This trial will be a randomized controlled study comparing the efficacy and safety of intraoperative radiation therapy using GammaTilesTM (GT) versus SRT 3-4 weeks following metastatic tumor resection which is the current standard of care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania
Conditions: Brain Metastases
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Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients
NCT04310020
Recruiting
This phase II trial studies the side effects of radiation therapy followed by atezolizumab in treating patients with stage II or III non-small cell lung cancer. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more cancer cells and have fewer side effects. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to g... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: UPMC Hillman Cancer Center Erie, Erie, Pennsylvania
Conditions: Stage II Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Lung Non-Small Cell Carcinoma
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