Pennsylvania is currently home to 3305 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
COVID-19 Vaccines Safety Tracking (CoVaST)
NCT04834869
Recruiting
This project aims to monitor the side effects of COVID-19 vaccines worldwide actively. The primary objectives of the project include a) to estimate the prevalence of each local and systemic side effect of each COVID-19 vaccine among healthcare workers (HCW), old adults over +65 (OA), and schoolteachers (ST); b) to evaluate the potential demographic and medical risk factors for side effects frequency and intensity; c) to evaluate the long-term consequences of COVID-19 vaccines. The secondary obje... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/05/2022
Locations: American College of Physicians, Philadelphia, Pennsylvania
Conditions: Adverse Reaction to Vaccine, COVID19 Vaccine
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Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD)
NCT03540771
Recruiting
This is a comparative effectiveness study of two pragmatic models aiming to introduce palliative care for end stage liver disease patients. The 2 comparators are: Model 1: Consultative Palliative Care (i.e. direct access to Palliative Care provider), Model 2: Trained Hepatologist- led PC intervention (i.e. a hepatologist will receive formal training to deliver Palliative Care services) Primary Outcome: The change in quality of life from baseline to 3 months post enrollment as assessed by FACT-... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
04/05/2022
Locations: Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania
Conditions: End Stage Liver Disease
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KRT-232 and TKI Study in Chronic Myeloid Leukemia
NCT04835584
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Ph+ Chronic Myeloid Leukemia (CML) who have relapsed or are refractory or intolerant to a Tyrosine Kinase Inhibitor (TKI). This study is a global, open label Phase 1b/2 to determine the efficacy and safety of KRT-232 in patients with chronic phase CML (CML-CP) and accelerated phase (CML-AP) who have failed TKI treatments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2022
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Chronic Myeloid Leukemia
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Qualification for Cone-Optogenetics
NCT05218928
Recruiting
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Gender:
All
Ages:
All
Trial Updated:
01/19/2022
Locations: University of Pittsburgh, Department of Ophthalmology, Pittsburgh, Pennsylvania
Conditions: Retinal Dystrophies
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Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT05211856
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Pittsburgh, Pennsylvania
Conditions: Chronic Lymphocytic Leukemia
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Probiotics and Gut Health
NCT03418857
Recruiting
This study evaluates the effects of probiotic consumption on inflammatory outcomes and measures of gut health. Participants will be given yogurt with probiotics for one period and yogurt without probiotics for another, with a break in between. These periods will occur in random order.
Gender:
ALL
Ages:
Between 55 years and 75 years
Trial Updated:
12/12/2021
Locations: The Pennsylvania State University, University Park, Pennsylvania
Conditions: Metabolic Syndrome
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CapTem Plus Radioembolization for NET Liver Metastases
NCT04789109
Recruiting
Grade 2 neuroendocrine tumors have an intermediate rate of progression following embolotherapy of liver metastases. The combination of capecitabine and temozolomide has been shown to be an active regimen in this disease. Both drugs are radiosensitizers, and in a safety and feasibility study were combined with yttrium-90 radioembolization with acceptable additive toxicities and better than expected response and duration of disease control. This study expands use of this regimen in a Phase 2 inves... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/01/2021
Locations: Abramson Cancer Center, Philadelphia, Pennsylvania
Conditions: Neuroendocrine Tumor Grade 2, Liver Metastases
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Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies, the PROCEED Study
NCT04753255
Recruiting
This study gathers information on patients at different stages of chronic pancreatitis to better understand the natural course and risk factors associated with pancreatitis. Chronic pancreatitis is a disease that occurs when the pancreas is inflamed (swollen and irritated) all of the time. It is important for doctors to diagnose chronic pancreatitis in the beginning stages of the disease. Over time, as chronic pancreatitis gets worse, the pancreas may stop working correctly. Since treatment opti... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/22/2021
Locations: University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
Conditions: Acute Pancreatitis, Chronic Pancreatitis
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An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04718818
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Uniontown, Pennsylvania
Conditions: Ulcerative Colitis
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Spinal Cord Injury Registry - North American Clinical Trials Network
NCT00178724
Recruiting
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI). Information will be collected on the natural history of SCI and course of treatment through the first 12 months from the date of injury or long as medically indicated. Data collected includes imaging information from CT or MRI scans, neurological a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/22/2020
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Spinal Cord Injury
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Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
NCT04275453
Recruiting
The purpose of this study is to test different methods of preparation that can be used prior to a test called an FDG PET/CT scan. FDG PET/CT scans are routinely done for evaluation of heart inflammation. Standard preparation for the scan includes a ketogenic (high fat and low carbohydrate) diet for 24 hours and overnight fasting to help suppress the amount of sugar taken up in the heart muscle. However, Investigator still do not know if this preparation is the most effective method. So the Inves... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2020
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Healthy
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VENOUS: A Translational Study of Enterococcal Bacteremia
NCT04410276
Recruiting
The purpose of this study is to assemble a multicenter prospective cohort of patients with enterococcal bloodstream infections (BSIs) to provide data on outcomes of patients with enterococcal BSIs for sample size calculations for future trials, as well as to characterize enterococcal isolates causing BSIs in order to comprehensively dissect the molecular epidemiology of infecting organisms for future studies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/26/2020
Locations: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Conditions: Enterococcal Bacteremia
Register for Updates