Pennsylvania is currently home to 3307 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Dosing of LT4 in Older Individuals
NCT06073665
Recruiting
Our overall goal is to determine the clinical consequences of allowing greater flexibility in LT4 dosing in older individuals who take LT4.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
02/25/2025
Locations: Penn Medicine, Smilow Translational Research Center, Philadelphia, Pennsylvania
Conditions: Hypothyroidism
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Advancing Transplantation Outcomes in Children
NCT06055608
Recruiting
This is a pediatric kidney transplant study comparing the safety and efficacy of an immunosuppressive regimen of belatacept and sirolimus to tacrolimus and Mycophenolate Mofetil (MMF). Two hundred participants will be randomized (1:1) to one of two groups within 24 hours following the transplant procedure. The duration of the study from time of transplant to the primary endpoint is 12-24 months.
Gender:
ALL
Ages:
Between 13 years and 20 years
Trial Updated:
02/25/2025
Locations: Children's Hospital of Philadelphia (Site #: 71091), Philadelphia, Pennsylvania
Conditions: Kidney Transplant
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REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study
NCT06041386
Recruiting
This is a prospective, real-world, single arm, global, multi-centre study to evaluate the effect of timely treatment with mepolizumab (NUCALA) to achieve clinical remission in adult participants with severe asthma with an eosinophilic phenotype (SA-EP).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: GSK Investigational Site, Philadelphia, Pennsylvania
Conditions: Asthma
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Accelerated Transcranial Magnetic Stimulation for People with Schizophrenia Treated with Clozapine
NCT06003036
Recruiting
In this study, the investigators will examine whether a type of repetitive transcranial magnetic stimulation called accelerated intermittent theta burst stimulation (iTBS) can augment neurocognition in individuals who receive treatment with clozapine. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will undergo a session of iTBS +MRI and session of sham delivery + MRI. The order for these sessions will be blinded and randomized. The investigators predict that a... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
02/25/2025
Locations: UPMC Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Schizophrenia, Schizoaffective Disorder
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Longitudinal Study for Central Nervous System Vasculitis
NCT05734404
Recruiting
Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech impairment, visual loss, dementia, and encephalopathy. The purpose of this study is to establish a research cohort to investigate the disease process, treatments, and patient outcomes in CNSV.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Central Nervous System Vasculitis, CNS Vasculitis, CNSV, Vasculitis
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Promoting Recovery After STroke with Amantadine
NCT05140148
Recruiting
The investigators aim to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial (RCT). Patients will be randomized post-ischemic or hemorrhagic stroke either to the placebo arm or amantadine arm. Patients will be on study drug or placebo for 1 month but will be enrolled for 3 months total. At various time points patients will be examined and fill out questionnaires to determine level of stroke recovery.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
02/25/2025
Locations: The Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Stroke, Ischemic, Stroke Hemorrhagic
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Longitudinal Study for Relapsing Polychondritis
NCT04919538
Recruiting
Relapsing polychondritis (RP) is a rare systemic inflammatory disease characterized by recurrent inflammation of cartilage including ears, nose, tracheobronchial tree, chest wall and joints. Less commonly, it can cause inflammation of eyes, vasculature, nervous system, skin and inner ear. The purpose of this study is to study the pathogenesis of RP.
Gender:
ALL
Ages:
All
Trial Updated:
02/25/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Relapsing Polychondritis, Vasculitis
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HeartStart HS1 Defibrillator* Event Registry
NCT04840797
Recruiting
A Prospective study on the performance and safety of the HeartStart OnSite (Model M5066A) \& HeartStart Home (Model M5068A) Defibrillator device data.
Gender:
ALL
Ages:
All
Trial Updated:
02/25/2025
Locations: Philips, Pittsburgh, Pennsylvania
Conditions: Sudden Cardiac Arrest
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CD123 Redirected T Cells for AML in Pediatric Subjects
NCT04678336
Recruiting
Phase 1 open-label study to evaluate the safety of intravenously administered, lentivirally transduced T cells expressing anti-CD123 chimeric antigen receptors expressing tandem TCRζ and 4-1BB (TCRζ /4-1BB) costimulatory domains in pediatric subjects with relapsed/refractory Acute Myeloid Leukemia (AML).
Gender:
ALL
Ages:
Between 1 year and 29 years
Trial Updated:
02/25/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia, Pediatric, Acute Myeloid Leukemia, Refractory
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HeartStart FRx Defibrillator Event Registry
NCT04250857
Recruiting
This post market clinical follow-up study is a multi-center, non-randomized, unblinded, observational registry of the performance of the FRx Automated external defibrillator (AED) used in conjunction with electrodes with or without use of the infant/child key. The registry is focused only on on post-event data collection and does not prescribe any device usage. This registry has several safeguards in place to prevent against selections bias, including enrollment of all participants who have pads... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/25/2025
Locations: Philips, Monroeville, Pennsylvania
Conditions: Sudden Cardiac Arrest
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Amplatzer Amulet LAAO Vs. NOAC
NCT04226547
Recruiting
The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-term NOAC therapy. The clinical investigation is a prospective, randomized, multicenter active control worldwide trial. Subjects will be randomized in a 1:1 ratio between the Amulet LAA occlusion device ("Device Group") and a commercially available NOAC medication ("Cont... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Pinnacle Health System, Harrisburg, Pennsylvania
Conditions: Atrial Fibrillation, Stroke, Bleeding
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The Radiation Oncology Registry and Biosample Repository
NCT01577251
Recruiting
The goal of this study is to establish a registry and biosample repository (defined as blood, urine, and tumor specimens) in patients with a cancer and/or benign tumor diagnosis undergoing radiotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Lancaster General Hospital, Lancaster, Pennsylvania
Conditions: Neoplasia
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