Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement
NCT04732962
Recruiting
Osteoarthritis (OA), the most common type of arthritis, affects more than 32.5 million adults in the United States. It is also among the most expensive condition to treat when joint replacement surgery is required. Although biomechanics plays an important role in OA disease, the non-surgical treatment options addressing biomechanics are scarce with limited effect. AposHealth is the fist biomechanical treatment that was shown to have a significant short-term effect on patients with knee OA. The... Read More
Gender:
ALL
Ages:
Between 45 years and 80 years
Trial Updated:
04/28/2025
Locations: Geisinger Medical Center, Danville, Pennsylvania
Conditions: Osteoarthritis, Knee
Register for Updates
ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES
NCT04503395
Recruiting
The aim of this randomized study is to compare the safety and performance of EndoVascular Aneurysm Repair with ESAR using Endurant + Heli-FX™ EndoAnchor™ system and FEVAR using customizable grafts from Cook (Zenith Fenestrated Graft) and Terumo (Fenestrated Anaconda Graft) for the treatment of aortic aneurysms with short aortic neck (4 to 15mm).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/28/2025
Locations: Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Aortic Aneurysm, Abdominal
Register for Updates
Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)
NCT04202341
Recruiting
Long-term, multicenter, multinational, observational, registry of patients with gMG that is designed to collect data on clinical outcomes and safety in patients prescribed Alexion C5 inhibitor therapies (C5IT) such as eculizumab (Soliris®) and ravulizumab (Ultomiris®).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/28/2025
Locations: Clinical Trial Site, Philadelphia, Pennsylvania
Conditions: Generalized Myasthenia Gravis
Register for Updates
Project REST: Regulation of Eating and Sleep Topography
NCT04057716
Recruiting
Overweight/obesity and inadequate sleep are prevalent, and frequently co-occurring, health risks among children, both of which are associated with serious medical and psychosocial health complications including risk for cardiovascular disease. Although the investigator's data suggest that disrupted or shortened sleep may be causally associated with increased energy intake and weight gain in children, and with self-regulation and neural response to food cues in adults, understanding of mechanisms... Read More
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
04/28/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Obesity, Childhood, Binge Eating, Sleep, Self-regulation
Register for Updates
Amish/Mennonite Research Contact Registry
NCT02990572
Recruiting
The purpose of this registry is to find members of the Plain Community who are interested in participating in future medical research studies. Having a registry makes it easier to contact and offer study participation to individuals who are appropriate for a new research study based on their own and their family medical history. Studies will focus on increasing knowledge about disorders affecting those who are Amish and Mennonite.
Gender:
ALL
Ages:
All
Trial Updated:
04/28/2025
Locations: Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: All
Register for Updates
Exome and Genome Analysis to Elucidate Genetic Etiologies and Population Characteristics in the Plain Community
NCT02927158
Recruiting
This study is designed to utilize whole exome and whole genome sequencing techniques to identify underlying genetic causes for undiagnosed disorders in the Plain Communities, and to do population genetic studies looking at genetic drift and founder mutations in this unique population.
Gender:
ALL
Ages:
100 years and below
Trial Updated:
04/28/2025
Locations: Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Conditions: Undiagnosed Disease
Register for Updates
Heart Attack Research Program- Imaging Study
NCT02905357
Recruiting
The HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in patients with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every 6 months, for a maximum of 10 years.
Gender:
ALL
Ages:
Between 21 years and 99 years
Trial Updated:
04/28/2025
Locations: St. Luke's University Health Network, Bethlehem, Pennsylvania
Conditions: Myocardial Infarction
Register for Updates
Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery
NCT06747390
Recruiting
Based on evidence that the local anesthetic lidocaine may have anticancer effects, this study will assess the safety and efficacy of intratumoral lidocaine injection at the time of direct laryngoscopy prior to TransOral Robotic Surgery (TORS) and neck dissection for oropharyngeal squamous cell carcinoma (OPSCC). The primary objective of the study is to determine if intratumoral lidocaine injection is safe and causes a major pathologic treatment effect in the primary tumor following surgical rese... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/27/2025
Locations: Abramson Cancer Center at University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Oropharyngeal Squamous Cell Carcinoma (OPSCCA), Oropharyngeal Cancer, Human Papilloma Virus, Squamous Cell Carcinoma
Register for Updates
Variability in Analgesic Response to Ibuprofen
NCT06539741
Recruiting
Nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, are recommended as first-line treatment for post-surgical dental pain. However, there is variability in analgesic response, and some patients require supplemental opioids for adequate pain relief. The goal of this study is to identify the factors that contribute to the need for opioid after third molar extraction to help limit unnecessary opioid prescriptions in patients who will have good pain relief with ibuprofen alone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania
Conditions: Impacted Third Molar Tooth, Pain, Acute
Register for Updates
AZD0486 as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL
NCT06526793
Recruiting
This is a Phase 2 global, multi-center, open-label study to assess the efficacy, safety and tolerability of AZD0486 monotherapy in adult participants with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL) who have received at least two prior lines of therapies. The study has 2 Modules: Module 1 for FL and Module 2 for DLBCL.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/25/2025
Locations: Research Site, Philadelphia, Pennsylvania
Conditions: B-cell Non-Hodgkin Lymphoma, Follicular Lymphoma (FL), Diffuse Large B-Cell Lymphoma (DLBCL)
Register for Updates
Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders
NCT06512181
Recruiting
This study for the conservative management of placenta accreta spectrum disorders (PAS), which are a major cause of maternal morbidity and mortality. The most common management strategy for PAS in the United States is a preterm cesarean-hysterectomy. However, accumulating data show that conservative management is safer and is preferred by some patients. In selected participants (n=15) who desire uterine preservation, the investigators provide the option of conservative management, which will be... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Placenta Accreta Spectrum
Register for Updates
Study of IK-595 in RAS- or RAF-altered Advanced Tumors
NCT06270082
Recruiting
This is a Phase 1, FIH, Dose Escalation and Dose Expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) effects, and preliminary antitumor activity of IK-595, a MEK/RAF molecular glue, administered orally as monotherapy in patients with advanced solid tumors with gene alterations in the RAS- MAPK pathway for whom there are no further treatment options known to confer clinical benefit.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Solid Tumor, Adult, Colorectal Cancer, Pancreatic Cancer, Malignant Melanoma, Ras (Kras or Nras) Gene Mutation, BRAF Gene Mutation, CRAF Gene Mutation, Non-Small Cell Lung Carcinoma, Thyroid Carcinoma, Gliomas, Malignant
Register for Updates