Pennsylvania is currently home to 3373 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Multicentre Prospective Study Evaluating an Off-loading Mattress Overlay System in Healing of Stage 3 Pressure Ulcers
NCT05033470
Recruiting
This study will evaluate the use of a mattress overlay system to promote the healing of full thickness pressure ulcers. The overlay is placed over the patient's bed making it easier for patients to get in and out of bed. In addition, the overlay has blue tooth capabilities that will allow clinicians to remotely monitor adherence with the device.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/03/2022
Locations: SunnyView, Butler, Pennsylvania
Conditions: Pressure Ulcer
Register for Updates
Evaluating the Efficacy of Dual Layer Amniotic Membrane (Artacent®)
NCT04457752
Recruiting
A Randomized Controlled Multicenter Clinical Trial, Evaluating the Efficacy of Dual Layer Amniotic Membrane (Artacent®) and Standard of Care versus Standard of Care alone in the healing Chronic Diabetic Foot Ulcers. Multi-center, open label, randomized controlled trial. Study is estimated to require 12 months from first subject enrolled to last subject visit.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/03/2022
Locations: The Foot and Ankle Wellness Center of Western Pennsylvania, Ford City, Pennsylvania
Conditions: Chronic Diabetic Foot Ulcers
Register for Updates
Acute Low Back Pain in the Emergency Department Treated With Osteopathic Manipulative Treatment Versus NSAIDs
NCT04129437
Recruiting
Acute low back pain is the fifth most common presenting complaint to the emergency department, accounting for approximately 4.4% of annual visits. The treatment for acute low back pain is often NSAIDs or other analgesic medications. Osteopathic Manipulative Treatment (OMT) has been shown to be an effective treatment modality for acute low back pain, however, it's use in the emergency department setting is not well described. The adjunct of OMT has the potential to increase patient satisfaction,... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/02/2022
Locations: AEHN, Philadelphia, Pennsylvania
Conditions: Low Back Pain
Register for Updates
2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
NCT04012996
Recruiting
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease (SCDD).
Gender:
ALL
Ages:
Between 18 years and 69 years
Trial Updated:
10/27/2022
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Symptomatic Cervical Disc Disease
Register for Updates
Study of Low-dose Naltrexone in Chronic Migraine With Fibromyalgia
NCT05536050
Recruiting
This research aims to look at the effect of low-dose naltrexone on the severity and frequency of attacks in people with chronic migraine with or without new daily persistent headache and fibromyalgia. A few studies suggest low-dose naltrexone is effective for fibromyalgia, but it has not been studied in patients with migraine and headaches. Our goal is to see if there is an improvement in either severity and frequency of attacks and overall impact on quality of life over a three-month period.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/25/2022
Locations: Jefferson Headache Center, Philadelphia, Pennsylvania
Conditions: Chronic Migraine, Fibromyalgia, New Daily Persistent Headache
Register for Updates
Safety and Effectiveness of the CustomFlex Artificial Iris Prosthesis for the Treatment of Iris Defects
NCT01860612
Recruiting
The purpose of this study is to study the long term safety and effectiveness of an artificial iris prosthesis for the treatment of iris defects.
Gender:
ALL
Ages:
3 years and above
Trial Updated:
10/21/2022
Locations: Wills Eye Institute, Philadelphia, Pennsylvania
Conditions: Full Aniridia, Partial Aniridia
Register for Updates
Functional Lung Imaging in Patients With Respiratory Compromise Undergoing Endobronchial Valve Placement
NCT05204875
Recruiting
Bronchoscopic lung volume reduction (BLVR) using endobronchial valves is effective in improving quality of life in patients suffering from emphysema. BLVR treatment in advanced emphysema requires targeted segmental or sub-segmental placement of endobronchial valves (EBV) to achieve total lobar occlusion to induce effective lobar volume reduction. BLVR procedure success rate declines in patients with incomplete lobar fissure integrity due to the potential for collateral ventilation to circumvent... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
10/20/2022
Locations: Temple University Hospital, Philadelphia, Pennsylvania
Conditions: Emphysema
Register for Updates
CERENOVUS Neurothrombectomy Devices Registry
NCT05591183
Recruiting
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: Geisinger Clinic, Danville, Pennsylvania
Conditions: Cerebral Stroke
Register for Updates
Genes and Environment in Multiple Sclerosis
NCT01353547
Recruiting
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS wil... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2022
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Multiple Sclerosis
Register for Updates
A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors
NCT04843709
Recruiting
The objective of this study is to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of MRG004A in patients with Tissue Factor positive advanced or metastatic solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/06/2022
Locations: Gettysburg Cancer Center, Gettysburg, Pennsylvania
Conditions: Advanced or Metastatic Solid Tumors
Register for Updates
REFINE Study: A Prospective Study In a Novel Interspinous Fusion Device In Subjects With Low Back Pain
NCT05504499
Recruiting
The purpose of this study is to evaluate the effectiveness and safety of the use of Aurora Spine ZIP™ MIS Interspinous Fusion System and bone graft material in fusion in patients with chronic low back pain that present with degenerative disc disease with concurrent neurogenic claudication.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/15/2022
Locations: Center for Interventional Pain and Spine, Chadds Ford, Pennsylvania
Conditions: Lumbar Spinal Stenosis
Register for Updates
Diagnostic Accuracy and Safety of DBV1605 for the Diagnosis of Non-IgE Mediated Cow's Milk Allergy in Children
NCT04492683
Recruiting
Study to assess the diagnostic accuracy (sensitivity, specificity, positive and negative predictive value) of DBV1605 for the diagnosis of non-Immunoglobulin E (IgE) mediated cow's milk allergy (CMA) in children with symptoms suggestive of non-IgE mediated CMA.
Gender:
All
Ages:
Between 29 days and 24 months
Trial Updated:
08/09/2022
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Cow's Milk Allergy
Register for Updates