Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines
NCT06929455
Recruiting
Many people, particularly small children, must take drugs in liquid form because they cannot swallow pills or capsules. The bad taste of some liquid drugs can keep patients from taking drugs they need for their health. Our main goal in this research study is find ingredients that might make drugs taste better. Participants in this research study will be healthy adults between the ages of 18 and 60 years old. Participants will taste samples (liquids or gels) containing active pharmaceutical ingr... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/14/2025
Locations: Monell Chemical Senses Center, Philadelphia, Pennsylvania
Conditions: Healthy Adults
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Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
NCT06767566
Recruiting
The purpose of this study is to identify pharmacokinetics of postpartum ketamine infusion. This study will assess ketamine kinetics and metabolism in this setting. Ketamine is expected to exert different kinetics during the physiologic state of post-pregnancy. The goal in conducting this study is to better understand the pharmacokinetics and pharmacodynamics of postpartum ketamine infusion. A secondary goal is to compare these kinetics to reproductive age matched controls and to assess sex diffe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania
Conditions: Pain, Postpartum Depression
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PREVENT ALL ALS Study
NCT06581861
Recruiting
The ALL ALS Clinical Research Consortium is establishing research to collect a wide range of samples, clinical information and measurements from Amyotrophic Lateral Sclerosis (ALS) symptomatic, ALS gene carriers and control cohorts. This consortium is begin funded by the National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) and managed by two clinical coordinating centers (CCC) at Barrow Neurological Institute and Massachusetts General Hospital. The cl... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Penn State Health, Hershey, Pennsylvania
Conditions: Amyotrophic Lateral Sclerosis
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iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH
NCT05442671
Recruiting
Children with pulmonary hypertension (PH) engage in less physical activity than their peers. This is a concern since adult data support exercise as a non-pharmacologic treatment for PH. Despite adult data, therapeutic exercise has not been widely adopted in pediatric PH. Investigators have previously demonstrated that children with PH have less skeletal muscle mass in association with worse exercise performance. Interventions to increase physical activity and skeletal muscle mass may improve exe... Read More
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
04/14/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Pulmonary Hypertension
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Harm Reduction in HIV Primary Care for PLWH Who Use Drugs
NCT05404750
Recruiting
People living with HIV (PLWH) who use drugs experience significant health disparities including lower rates of retention in HIV care and higher rates of unsuppressed viral load, resulting in secondary infections and increased mortality. The proposed study will used mixed methods to explore (a) the relationship between healthcare providers' attitudes towards working with PLWH who use drugs and providers' acceptance and practice of structural and relational harm reduction; (b) the degree to which... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Allegheny Health Network Research Institute, Pittsburgh, Pennsylvania
Conditions: Human Immunodeficiency Virus, Substance Use, Stigma, Social
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Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants With NMOSD
NCT05346354
Recruiting
The primary purpose of this study is to evaluate the safety and efficacy of ravulizumab in pediatric participants with Neuromyelitis Optica Spectrum Disorder (NMOSD).
Gender:
ALL
Ages:
All
Trial Updated:
04/14/2025
Locations: Research Site, Philadelphia, Pennsylvania
Conditions: Neuromyelitis Optica Spectrum Disorder
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Intraoperative Contrast-Enhanced Ultrasound Evaluation of Blood Flow at the Time of Surgical Hip Reduction for DDH
NCT03107520
Recruiting
This study evaluates the feasibility and utility of contrast-enhanced ultrasound to provide real-time assessment of blood flow to the femoral head in infants undergoing surgical reduction for developmental dysplasia of the hip.
Gender:
ALL
Ages:
Between 4 months and 24 months
Trial Updated:
04/14/2025
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Developmental Dysplasia of the Hip
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Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
NCT00904241
Recruiting
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
Gender:
ALL
Ages:
30 years and below
Trial Updated:
04/14/2025
Locations: Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Conditions: Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Regional Neuroblastoma, Stage 4 Neuroblastoma, Stage 4S Neuroblastoma
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Esophageal Cancer Risk Registry
NCT00260585
Recruiting
The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow for early detection and prevention. Survival and an opportunity for a cure with esophageal cancer wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/13/2025
Locations: Department of Cardiothoracic Surgery, Pittsburgh, Pennsylvania
Conditions: Esophageal Cancer, Gastroesophageal Reflux Disease (GERD), Esophageal Diseases, Hiatal Hernia, Esophageal Achalasia
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Outcomes After Esophagectomy With a Focus on Minimally Invasive Esophagectomy and Quality of Life
NCT00260559
Recruiting
To assess short and long term outcomes after minimally invasive esophagectomy compared to open esophagectomy. To compare both standard outcome measures as well as patient derived outcome measures, in particular, quality of life (QOL). To look at the applicability of this QOL instrument to this patient group.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/13/2025
Locations: University of Pittsburgh Medical Center - Department of Cardiothoracic Surgery, Pittsburgh, Pennsylvania
Conditions: Esophagectomy, Esophageal Cancer
Register for Updates
Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults
NCT06743373
Recruiting
The goal of this study is to learn how cannabis use and discontinuation affect sleep, circadian rhythms, and sensitivity to light. The main questions it aims to answer are: 1. Does cannabis use and discontinuation impact sleep drive? 2. Does cannabis use and discontinuation impact light sensitivity and circadian phase?
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
04/11/2025
Locations: Western Psychiatric Hospital (Thomas Detre Hall), Pittsburgh, Pennsylvania
Conditions: Cannabis Use, Sleep, Circadian Rhythm
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Targeted EHR-based Communication of Diagnostic Uncertainty in the ED
NCT06638021
Recruiting
The goal of the clinical trial is to evaluate the preliminary effectiveness and the implementation feasibility of the Targeted EHR-based Communication about Uncertainty (TECU) strategy in improving the quality of care transitions from the emergency department (ED) to home. The overall specific aims related to the trial are to test the preliminary effectiveness of TECU compared to standard of care in reducing patient uncertainty and return ED visits and evaluate the adoption of TECU, exploring pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Diagnostic Uncertainty
Register for Updates