Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of VET3-TGI in Patients With Solid Tumors
NCT06444815
Recruiting
VET3-TGI is an oncolytic immunotherapy designed to treat advanced cancers. VET3-TGI has not been given to human patients yet, and the current study is designed to find a safe and effective dose of VET3-TGI when administered by direct injection into tumor(s) (called an intratumoral injection) or when given intravenously (into the vein) both alone and in combination with pembrolizumab in patients with solid tumors (STEALTH-001).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: UPMC- Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Solid Tumor, Adult, Microsatellite Stable Colorectal Cancer, Head and Neck Squamous Cell Carcinoma, Cervical Cancer, Kidney Cancer, Renal Cell Carcinoma, Melanoma Stage IV, Merkel Cell Carcinoma of Skin, Mesothelioma, Non-small Cell Lung Cancer
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Enriched Holistic Care to Eradicate Disparities in Maternal Morbidity
NCT06245057
Recruiting
The goal of this randomized controlled intervention trial is to evaluate an integrated, interdisciplinary, multi-level maternity care home model (MCHM) aimed at reducing severe maternal morbidity (SMM) among a group of Black indigenous and people of color (BIPOC) patients. The main question it aims to answer is whether a patient-centered MCHM will address the gap in social, structural, and health system factors that contribute to disparities for the most vulnerable patients, thereby reducing SM... Read More
Gender:
FEMALE
Ages:
Between 16 years and 55 years
Trial Updated:
04/09/2025
Locations: Hospital of the University of Pennsylvania, Phialdelphia, Pennsylvania
Conditions: Morbidity;Perinatal
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CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos
NCT06139159
Recruiting
Latinos in the U.S. experience significant disparities in access to mental health services due to lack of health insurance, language barriers, low availability of bilingual providers, mental health stigma, and fear of deportation. There is an urgent need to identify low-cost, culturally appropriate interventions to reduce mental health disparities among this population. This project will address that need by implementing and testing CRISOL Mente, a multi-level, culturally-congruent community int... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/09/2025
Locations: Drexel University School of Public Health, Philadelphia, Pennsylvania
Conditions: Depression, Unipolar, Anxiety Disorders, Post Traumatic Stress Disorder
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A Clinical Study That Will Measure How Well SEP-363856 Works and How Safe it is in Adults With Generalized Anxiety Disorder
NCT05729373
Recruiting
A clinical study that will meaure how well SEP-363856 works and how safe it is in adults with Generalized Anixety Disorder. This study will be accepting both male and female subjects between the ages of 18 years and 65 years old. The study will be held in Approximately 50 global study centers and approximately 15 additional centers for a separate Japan population. Participation in the study can be up to approximately 12 weeks.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/09/2025
Locations: Lehigh Center for Clinical Research, LLC, Allentown, Pennsylvania
Conditions: Generalized Anxiety Disorder
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FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study
NCT05639543
Recruiting
The purpose of this trial is to assess dose related safety, efficacy, and pharmacokinetics (PK) of INT-787 in participants with severe alcohol-associated hepatitis (sAH).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/09/2025
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Alcohol Associated Hepatitis
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Home Apnea Testing in CHildren Trial
NCT05382754
Recruiting
This clinical trial will compare home sleep apnea testing with the gold standard in-lab polysomnography in terms of 1) accuracy, 2) therapeutic decision-making, and 3) parent/child acceptability in children referred for evaluation of obstructive sleep apnea.
Gender:
ALL
Ages:
Between 5 years and 12 years
Trial Updated:
04/09/2025
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Sleep Apnea, Obstructive, Sleep Disorder, Sleep Apnea Syndromes, Sleep Disturbance
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A Study to Evaluate Safety, Efficacy of FF-10832 in Combo With Pembrolizumab in Urothelial & Non-small Cell Lung Cancer
NCT05318573
Recruiting
To confirm a recommended Phase 2 dose (RP2D) of FF-10832 (Gemcitabine Liposome Injection) given intravenously Day 1 of a 21-day cycle, in combination with 200 mg pembrolizumab given intravenously Day 1 of the same 21-day cycle, for treatment of advanced urothelial and non-small cell lung cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Hospital of the Univ of Pennsylvania Perlman Center, Philadelphia, Pennsylvania
Conditions: Advanced Urothelial Carcinoma, Advanced Non Small Cell Lung Cancer
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Medtronic Cardiac Surgery PMCF Registry
NCT04073420
Recruiting
This registry is being conducted to support ongoing post-market surveillance activities.
Gender:
ALL
Ages:
All
Trial Updated:
04/09/2025
Locations: University of Pittsburgh Medical Center UPMC Presbyterian, Pittsburgh, Pennsylvania
Conditions: Valve Disease, Heart
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A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)
NCT03592472
Recruiting
This is a randomized, Phase 3, double-blind, placebo-controlled study of pazopanib plus abexinostat versus pazopanib plus placebo in patients with locally advanced unresectable or metastatic renal cell carcinoma (RCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: St. Luke's Hospital, Easton, Pennsylvania
Conditions: Renal Cell Carcinoma
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Characterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 Variants
NCT06930417
Recruiting
The goal of this observational natural history study is to better characterize development, transition to adulthood, health and behavior of individuals diagnosed with Williams syndrome (WS) or carrying other variants of 7q11.23 chromosome and to build a DNA and tissue biobank with samples donated by affected individuals. The study has multiple arms focused on different aspects of WS. Participants with genetic diagnosis of WS or other variants of 7q11.23 and their family members are eligible to p... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/08/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Williams Beuren Syndrome, Williams Syndrome, Williams Beuren Region Duplication, Dup7
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Assessing Patient Satisfaction and Confidence After Use of Educational Video to Augment Surgical Consent for Thyroid Surgery
NCT06918223
Recruiting
This study looks at how a short educational video can help people better understand thyroid surgery. Patients who have thyroid nodules and need surgery will be part of the study. Some patients will get the usual information from their doctor, while others will also watch a video that explains the surgery in a simple and clear way. The study will check if the video helps patients feel more confident about their decision, lowers anxiety, and helps them remember important information about their su... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Thyroid Cancer
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Army-SPRING Army-Suicide Prevention Research
NCT06547008
Recruiting
Every unit in the Connecticut Army National Guard has a Suicide Intervention Officer to provide suicide intervention education awareness for their unit, monitor for soldiers in crisis and connect soldiers with helping resources and agencies. Suicide Intervention Officers need support in this difficult role, yet there is limited guidance on how to help them. This study will shed light on how to support Suicide Intervention Officers and whether this support results in reduced suicide risk in their... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/04/2025
Locations: Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Suicide
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