Pennsylvania is currently home to 3308 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data
NCT04606264
Recruiting
This REMAP Periop ERP domain study falls under the Periop Core Protocol, which compares the different recommended strategies for enhancing recovery through the use of various standard of care treatments before, during and after surgery in all patients with elective surgical encounters at UPMC who meet eligibility criteria. The ERP domain seeks to enhance recovery by optimizing strategies of perioperative care through evaluating combinations of perioperative treatment, which consists of preopera... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: UPMC Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Perioperative Optimization
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Postmarketing Prospective Study of Melanoma Patients Treated With IMLYGIC® to Characterize Risk of Herpetic Infection
NCT02910557
Recruiting
A postmarketing Cohort study of Melanoma patients treated with IMLYGIC (Talimogene Laherparepvec) in clinical Practice to Characterize the risk of herpetic infection with detection of Talimogene Laherparepvec DNA among patients, close contacts, and health care providers; and long term safety in treated patients for up to 5 years after the first IMLYGIC dose.
Gender:
ALL
Ages:
All
Trial Updated:
10/04/2024
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Melanoma, Herpetic Infection
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Comparing Effects of Conventional Neurorehabilitation with Exoskeleton with High-intensity Gait Training
NCT06478680
Recruiting
The purpose of this research is to compare improvements between the rehab intervention with walking practice using the robotic exoskeleton versus walking practice that is vigorous enough to keep participants' heart rate over a certain target level during physical therapy sessions. Investigators want to compare improvements in your walking function and mental health that occur after 20 interventions. The study also aims to evaluate if participants' mental health, social support, and health litera... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Good Shepherd Rehabilitation, Allentown, Pennsylvania
Conditions: Stroke, Gait, Hemiplegic
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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
NCT05926765
Recruiting
This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Penn State, Hershey, Pennsylvania
Conditions: Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
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C-TIL051 in Non-Small Cell Lung Cancer
NCT05676749
Recruiting
The goal of this Phase 1 clinical study is test tumor infiltrating lymphocytes (known as C-TIL051) with NKTR-255 and anti-PD1 therapy for subjects with refractory non-small cell lung cancer. The purpose of this study is to: 1. Test the safety and ability for subjects to tolerate the TIL therapy 2. Measure to see how the NSCLC responds to the TIL therapy Participants will be asked to: * Provide a tumor sample prior to the start of any treatment which will be used to make the C-TIL051. * Recei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Allegheny Health Network-West Penn Hospital, Pittsburgh, Pennsylvania
Conditions: Metastatic Non Small Cell Lung Cancer
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PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using PI-2620
NCT05456503
Recruiting
The investigators will compare PI-2620 tau PET scans from patients with frontotemporal lobar degeneration (FTLD), patients with non-amnestic presentations of Alzheimer's disease (naAD), and demographically matched cognitively normal seniors.
Gender:
ALL
Ages:
45 years and above
Trial Updated:
10/03/2024
Locations: Perelman Center for Advance Medicine, Philadelphia, Pennsylvania
Conditions: Frontotemporal Lobar Degeneration, Alzheimer Disease, Cognitively Normal
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Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section
NCT05380531
Recruiting
The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: UPMC Magee Women's Hospital, Pittsburgh, Pennsylvania
Conditions: Cesarean Section Complications, Opioid Use
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Childhood Cancer Predisposition Study (CCPS)
NCT04511806
Recruiting
The Childhood Cancer Predisposition Study (CCPS) is a multi-center, longitudinal, observational study that will collect clinical and biological data and specimens from children with a cancer predisposition syndromes (CPS) and their relatives. The central hypothesis is that studying individuals at high risk for childhood cancer creates a unique opportunity for improving the understanding of carcinogenesis, tumor surveillance, early detection, and cancer prevention, which will collectively contri... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/03/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Pediatric Cancer
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Intralesional 5-Fluorouracil (5FU), Topical Imiquimod Treatment for SCC
NCT03370406
Recruiting
This clinical trial proposes to evaluate a relatively unexplored approach to treatment of squamous cell carcinoma (SCC) on the lower extremities. The strategy is to directly and specifically deliver drug to the tumor. For the proposed phase I clinical trial, the investigators will perform intralesional injections of a well characterized, potent chemotherapeutic agent 5-fluorouracil (5FU) with and without a topical application of 5% imiquimod to kill topically accessible SCC cells. The goal of th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: St. Margaret Hospital Dermatology, Pittsburgh, Pennsylvania
Conditions: Carcinoma, Squamous Cell
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Predicting Concussion Outcomes with Salivary MiRNA
NCT02901821
Recruiting
The purpose of this study is to identify changes in salivary ribosomal nucleic acid (RNA) expression that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.
Gender:
ALL
Ages:
Between 5 years and 21 years
Trial Updated:
10/03/2024
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Concussion, Mild
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Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
NCT02434393
Recruiting
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
10/03/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Major Depression, Late Life Depression (LLD)
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A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
NCT06129864
Recruiting
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT).
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
10/02/2024
Locations: Research Site, Philadelphia, Pennsylvania
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Register for Updates