Pennsylvania is currently home to 3297 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Cryoablation for Monomorphic Ventricular Tachycardia
NCT05675865
Recruiting
The objective of this clinical study is to evaluate the safety and effectiveness of the Adagio VT Cryoablation System in the ablation treatment of Sustained Monomorphic Ventricular Tachycardia (SMVT)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/27/2025
Locations: Hospital of University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Sustained VT
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Fecal Microbiota Transplant National Registry
NCT03325855
Recruiting
A national data registry of patients receiving fecal microbiota transplantation (FMT) or other gut-related-microbiota products designed to prospectively assess short and long-term safety and effectiveness
Gender:
ALL
Ages:
All
Trial Updated:
01/27/2025
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Fecal Microbiota Transplantation, Clostridium Difficile Infection, Gut Microbiome
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Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
NCT06482853
Recruiting
Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease. The purpose of this study is to find out if the investigational drug angiotensin-(1-7) can improve cardiovascular health in people with obesity and high blood pressure.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
01/24/2025
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Obesity, Hypertension
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Bright Light Therapy for OSA
NCT05917119
Recruiting
Persistent daytime symptoms of sleepiness in individuals with obstructive sleep apnea (OSA) who are using Continuous Positive Airway Pressure (CPAP) are associated with adverse long term medical and functional outcomes. Supplementary exposure to bright light has beneficial effects on sleep quality and daytime vigilance in healthy individuals and it has been increasingly applied in a variety of sleep and neuropsychiatric conditions. This study will explore the role of Bright Light Therapy (BLT),... Read More
Gender:
ALL
Ages:
Between 40 years and 65 years
Trial Updated:
01/24/2025
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Obstructive Sleep Apnea
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MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
NCT05655312
Recruiting
In this first-in human, phase I/IIa study, the safety and efficacy of \[212Pb\]VMT01, an alpha-particle emitting therapeutic agent targeted to melanocortin sub-type 1 receptor (MC1R) is being evaluated as a monotherapy and in combination with Nivolumab in subjects with unresectable and metastatic melanoma.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
01/23/2025
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Melanoma (Skin), Metastatic Melanoma, Melanoma Stage IV, Mucosal Melanoma, Melanoma Stage III
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MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
NCT05271578
Recruiting
To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigarette users) and smokers will undergo three separate acute exposure-episodes of electronic cigarette +/- nicotine and tobacco-cig. The MRI exams and blood draws will be performed pre- and post-exposure. The results will be compared against baseline values derived from a group of non-smokers/non-vapers,... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
01/23/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Vascular Reactivity, Serum Biomarkers
Register for Updates
Study of Belantamab Mafodotin as Pre- and Post-autologous Stem Cell Transplant and Maintenance for Multiple Myeloma
NCT04680468
Recruiting
This is a single-institution, single-arm, phase 2 study in which belantamab mafodotin (GSK2857916), an antibody-drug conjugate targeting B-cell maturation antigen (BCMA), will be administered to patients with multiple myeloma prior to and following high-dose melphalan and autologous stem cell transplantation (ASCT), in conjunction with standard lenalidomide maintenance. We hypothesize that administration of belantamab mafodotin as part of autologous stem cell transplant consolidation and mainten... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Myeloma
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Deep Brain Stimulation Effects in Patients with Opioid Use Disorder
NCT04354077
Recruiting
This is a pilot study to evaluate the safety and efficacy of deep brain stimulation (DBS) of the nucleus accumbens (NAc) as adjunctive treatment for treatment-refractory opioid use disorder. This study will include 3 individuals with opioid use disorder and relapsing opioid use despite active participation in a drug addiction treatment program.
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
01/23/2025
Locations: AHN Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Opioid-use Disorder
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iLookOut for Child Abuse -Online Learning Module for Early Childcare Providers
NCT02225301
Recruiting
Phase 1 was a randomized control trial that used a test-retest model to evaluate the impact of iLook Out for Child Abuse, an online, interactive learning module about reporting suspected child abuse. Delivered via a learning management system to early childhood professionals who work with infants and young children, this study assessed iLookOut's effect on 1) knowledge about reporting suspected child abuse; 2) attitudes toward reporting suspected child abuse; and 3) preparedness to protect child... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: Penn State Milton S. Hershey Medical Center / Penn State College of Medicine, Hershey, Pennsylvania
Conditions: Child Abuse, Child Neglect, Child Maltreatment
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Evaluating the Durability of Closure for Venous Leg Ulcers
NCT06697925
Recruiting
The goal of this observational study is to determine the durability of closure for venous leg ulcer subjects that achieved closure in the THOR trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: Serena Group, Monroeville, Pennsylvania
Conditions: Venous Leg, Venous Leg Ulcer (VLU), Venous Leg Ulcer, Venous Ulcer, VLU
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Evaluating Intact Fish Skin Graft and Standard of Care Versus Standard of Care Alone in Nonhealing Venous Leg Ulcers
NCT06693570
Recruiting
The purpose of this study is to determine the between-arm difference in the proportion of subjects achieving complete closure of hard-to-heal venous leg ulcers (VLU) between Intact Fish Skin Graft plus standard of care (IFSG/SOC) versus standard of care alone (SOC) over 12 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: Serena Group- Monroeville, Monroeville, Pennsylvania
Conditions: Venous Leg Ulcer (VLU), Venous Leg Ulcers, Venous Leg, Nonhealing Venous Leg Ulcer
Register for Updates
BINGO: Bridging Knowledge, Increasing Awareness
NCT06504407
Recruiting
The U.S. population is becoming more diverse, but minority groups are still significantly underrepresented in cancer clinical trials. This disparity limits our understanding of how treatments work across different populations. Efforts like the 21st Century Cures Act aim to improve inclusion, but challenges persist due to historical mistrust and complex barriers in healthcare. To address these issues, Penn State Health is using a fun and educational approach called "BINGO" to engage the African... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: Penn State Cancer Institute, Hershey, Pennsylvania
Conditions: Cancer Education, Health Equity
Register for Updates