Pennsylvania is currently home to 3308 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
NCT03827694
Recruiting
This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes for children at high-risk for pulmonary invasive fungal infection (PIFI).
Gender:
ALL
Ages:
Between 120 days and 21 years
Trial Updated:
09/24/2024
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Pulmonary Invasive Aspergillosis, Pulmonary Invasive Fungal Infections
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TmCD19-IL18 in CD19+ Cancers
NCT05989204
Recruiting
This is a Phase I, open-label dose finding study to assess the safety, tolerability, manufacturing feasibility, pharmacokinetics, and preliminary efficacy of TmCD19-IL18 CAR T cells in patients with CD19+ cancers. This study will take place in two parts: a Dose-Finding Phase to determine the maximum tolerate dose (MTD), followed by a Dose Expansion Phase. In the Dose-Finding Phase, up to 4 total dose levels will be evaluated using a 3+3 dose escalation design in order to determine the MTD (as de... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Non Hodgkin Lymphoma
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Adaptive Radiation for Abdominopelvic Metastases
NCT05880667
Recruiting
Single arm Phase I trial of adaptive stereotactic body radiation (SBRT) for abdominopelvic metastases. Adaptive SBRT will allow for escalation of the prescription dose and target coverage while maintaining grade 3+ toxicity no greater than 10%. Subjects with metastatic cancer to the abdomen or pelvis requiring local control or palliation will be enrolled.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Neoplasm - Soft Tissue Pelvis Malignant Secondary, Malignant Neoplasm of Stomach
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Low Dose Aspirin Alerts in High-Risk Pregnancies
NCT05802940
Recruiting
The goal of this study is to assess the effect of an electronic health record (EHR) clinical decision support tool, also known as a best practice alert (BPA), on healthcare provider recommendations for low dose aspirin use in a high-risk pregnant patient population. The investigators hypothesize that the implementation of the EHR BPA tool will increase the healthcare provider's recommendation for low dose aspirin compared to current standard care.
Gender:
FEMALE
Ages:
All
Trial Updated:
09/23/2024
Locations: Geisinger Medical Center, Danville, Pennsylvania
Conditions: Preeclampsia, Aspirin, Clinical Decision Support Systems, Economics, Behavioral
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Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients
NCT05669833
Recruiting
The trial is an open-label randomized study that will examine whether switching to a selective IL23 inhibitor (guselkumab) is more effective than switching to a second TNFi (golimumab) among patients with PsA who have an inadequate response to a TNFi.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/23/2024
Locations: Hospital at the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Psoriatic Arthritis
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TERPS Trial for De Novo Oligometastic Prostate Cancer
NCT05223803
Recruiting
This research is being done to see if we can improve the outcome of prostate cancer patients who present with metastatic lesions at initial diagnosis.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: Sidney Kimmel Cancer Center at Jefferson Health, Philadelphia, Pennsylvania
Conditions: Prostate Cancer, Oligometastatic Disease
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Effects of Theta Burst Stimulation on the Brain, Behavior, and Clinical Symptoms in Adults with Bipolar Disorder
NCT04696471
Recruiting
Bipolar Disorder (BD) is a common and highly debilitating psychiatric disorder, however, the predisposing brain mechanisms are poorly understood. Here, the investigators aim to examine the immediate effect of transcranial brain stimulation (TBS) on brain activity and emotions in adults with and without BD as a first stage toward understanding the predisposing brain mechanisms of BD. The investigators hypothesize that TBS will reduce brain activity while playing a game with rewards in all adults,... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
09/23/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Bipolar Disorder
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Neuro-affective Response to Light in Depressed Adolescents and Young Adults
NCT05712772
Recruiting
The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: * Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals? * Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than you... Read More
Gender:
ALL
Ages:
Between 12 years and 30 years
Trial Updated:
09/22/2024
Locations: Western Psychiatric Hospital, Pittsburgh, Pennsylvania
Conditions: Depression in Adolescence, Depression in Adults
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Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis
NCT06578637
Recruiting
The aim of this study is to evaluate the potential of BHB supplementation as a novel strategy to impede the development and progression of intestinal adenomas in individuals with FAP, thus reducing the need for frequent upper endoscopies and colonoscopies, and potentially preventing the need for risk-reducing surgical intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/21/2024
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: FAP, Familial Adenomatous Polyposis
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Guaranteed Income and Financial Treatment
NCT06611982
Recruiting
The goal of this clinical trial is to learn if providing advanced cancer patients with $1000/month for 12 months will improve cancer outcomes. The main questions it aims to answer are: To what extent does receiving $1000/month additional income reduce financial hardship? To what extent does receiving $1000/month additional income improve quality of life? Does receiving $1000/month additional income improve survival outcomes? Participants will: Receive $1000/month for 12 months Complete a surv... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2024
Locations: Penn Presbyterian Medical Center, Philadelphia, Pennsylvania
Conditions: Cancer, Financial Hardship, Quality of Life
Register for Updates
EXERT-BCH Exercise Regimen to Improve Muscle Mass After Treatment of Breast Cancer
NCT06115486
Recruiting
The purpose of this research study is to evaluate the outcomes of two standard of care group exercise regimens to increase muscle mass in women who have been treated with breast cancer.
Gender:
FEMALE
Ages:
Between 20 years and 89 years
Trial Updated:
09/20/2024
Locations: Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Breast Cancer, Breast Carcinoma in Situ, Breast Cancer Female
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Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial
NCT04095663
Recruiting
The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. A parallel observational cohort will include those who are disinclined to have their treatment choice randomized, but are willing to contribute information about their outcomes. The goal of the COSMID trial is to answer the question:... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2024
Locations: Penn Medicine, Philadelphia, Pennsylvania
Conditions: Diverticulitis
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