Pennsylvania is currently home to 3306 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study
NCT06119087
Recruiting
The goal of this clinical trial is to learn how doing mechanical insufflation (MI) using a mechanical insufflator-exsufflator (MI-E) device affects breathing in early amyotrophic lateral sclerosis (ALS). This will be a single-center, single-arm study of MI in 20 patients with ALS at Penn. Based on prior research, we believe that 6-months of MI may slow decline in cough strength, measured as peak cough flow (PCF). Participants will perform MI using a device designed for mechanical insufflation-... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure, Airway Clearance Impairment, Neuromuscular Diseases
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Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement
NCT05897788
Recruiting
There is growing recognition of the need for approaches to initiate treatment wherever patients touch the health care system, including the Emergency Department (ED). Most research has focused on initiation of medications for opioid use disorder (MOUDs) in the ED rather than ensuring continued treatment post-discharge. The investigators propose to adapt evidence-based interventions to support patients' complex needs and facilitate continued treatment, rather than discharging them and having them... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Opioid Use Disorder, Opioid Dependence With Current Use (Disorder)
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A Study to Evaluate Efficacy and Safety of Light Dose in Subjects with PWB Treated with Hemoporfin PDT
NCT05171894
Recruiting
This is a multi-center, randomized, double-blind, vehicle-controlled, and sequential group Phase 2 study. Eligible subjects aged 18 to 65 years old with PWB of face and/or neck area (except subjects for Stage One) will receive Hemoporfin PDT or vehicle PDT in 8-week cycles at fixed drug dose (5 mg/kg) and different light fluence.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/24/2024
Locations: St. Luke's University Health Network, Bethlehem, Pennsylvania
Conditions: Port-Wine Stain, Nevus Flammeus, Port-wine Birthmarks
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Parkinson's Disease and Movement Disorders Clinical Database
NCT04997642
Recruiting
The research database contains demographic and family history information, longitudinal information on the clinical symptoms, neuropsychological profile and treatments, stored biological samples, and brain images of patients with Parkinson's disease and related disorders receiving care at the Parkinson's disease and Movement Disorders Center and the Hospital of the University of Pennsylvania.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Parkinson Disease, Parkinson Disease Dementia, Lewy Body Parkinson Disease, Lewy Body Dementia With Behavioral Disturbance
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Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
NCT03827694
Recruiting
This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes for children at high-risk for pulmonary invasive fungal infection (PIFI).
Gender:
ALL
Ages:
Between 120 days and 21 years
Trial Updated:
09/24/2024
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Pulmonary Invasive Aspergillosis, Pulmonary Invasive Fungal Infections
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Adaptive Radiation for Abdominopelvic Metastases
NCT05880667
Recruiting
Single arm Phase I trial of adaptive stereotactic body radiation (SBRT) for abdominopelvic metastases. Adaptive SBRT will allow for escalation of the prescription dose and target coverage while maintaining grade 3+ toxicity no greater than 10%. Subjects with metastatic cancer to the abdomen or pelvis requiring local control or palliation will be enrolled.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Neoplasm - Soft Tissue Pelvis Malignant Secondary, Malignant Neoplasm of Stomach
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Low Dose Aspirin Alerts in High-Risk Pregnancies
NCT05802940
Recruiting
The goal of this study is to assess the effect of an electronic health record (EHR) clinical decision support tool, also known as a best practice alert (BPA), on healthcare provider recommendations for low dose aspirin use in a high-risk pregnant patient population. The investigators hypothesize that the implementation of the EHR BPA tool will increase the healthcare provider's recommendation for low dose aspirin compared to current standard care.
Gender:
FEMALE
Ages:
All
Trial Updated:
09/23/2024
Locations: Geisinger Medical Center, Danville, Pennsylvania
Conditions: Preeclampsia, Aspirin, Clinical Decision Support Systems, Economics, Behavioral
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Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients
NCT05669833
Recruiting
The trial is an open-label randomized study that will examine whether switching to a selective IL23 inhibitor (guselkumab) is more effective than switching to a second TNFi (golimumab) among patients with PsA who have an inadequate response to a TNFi.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/23/2024
Locations: Hospital at the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Psoriatic Arthritis
Register for Updates
TERPS Trial for De Novo Oligometastic Prostate Cancer
NCT05223803
Recruiting
This research is being done to see if we can improve the outcome of prostate cancer patients who present with metastatic lesions at initial diagnosis.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: Sidney Kimmel Cancer Center at Jefferson Health, Philadelphia, Pennsylvania
Conditions: Prostate Cancer, Oligometastatic Disease
Register for Updates
Effects of Theta Burst Stimulation on the Brain, Behavior, and Clinical Symptoms in Adults with Bipolar Disorder
NCT04696471
Recruiting
Bipolar Disorder (BD) is a common and highly debilitating psychiatric disorder, however, the predisposing brain mechanisms are poorly understood. Here, the investigators aim to examine the immediate effect of transcranial brain stimulation (TBS) on brain activity and emotions in adults with and without BD as a first stage toward understanding the predisposing brain mechanisms of BD. The investigators hypothesize that TBS will reduce brain activity while playing a game with rewards in all adults,... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
09/23/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Bipolar Disorder
Register for Updates
Neuro-affective Response to Light in Depressed Adolescents and Young Adults
NCT05712772
Recruiting
The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: * Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals? * Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than you... Read More
Gender:
ALL
Ages:
Between 12 years and 30 years
Trial Updated:
09/22/2024
Locations: Western Psychiatric Hospital, Pittsburgh, Pennsylvania
Conditions: Depression in Adolescence, Depression in Adults
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EXERT-BCH Exercise Regimen to Improve Muscle Mass After Treatment of Breast Cancer
NCT06115486
Recruiting
The purpose of this research study is to evaluate the outcomes of two standard of care group exercise regimens to increase muscle mass in women who have been treated with breast cancer.
Gender:
FEMALE
Ages:
Between 20 years and 89 years
Trial Updated:
09/20/2024
Locations: Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Breast Cancer, Breast Carcinoma in Situ, Breast Cancer Female
Register for Updates