Pennsylvania Clinical Trials

A listing of Pennsylvania clinical trials actively recruiting patient volunteers.

Now enjoying a moment in the sun thanks to the breakout popularity of Flyers mascot Gritty, Pennsylvania's capital Philadelphia has long been known as "The City of Brotherly Love" and home of the first public library in the United States. Founding Father Benjamin Franklin, a prolific inventor and author, spent much of his life in Philadelphia and left an indelible mark there. The U.S. Declaration of Independence, U.S Constitution, and Gettysburg Address were all written in Pennsylvania. The University of Pennsylvania is one of America's leading colleges, and UPMC Presbyterian, associated with the University of Pittsburgh, is the largest hospital.

Filter by Condition
3381 trials found

Clinical Development of Deep Learning for the TOMi Scope


The objective of this study is to clinically develop and evaluate a machine learning approach to improve the performance and data interpretation of the PhotoniCare TOMi Scope in pediatric patients presenting at the primary care office for suspected ear infections. In this observational study, results of TOMi Scope imaging will not affect patient standard of care.

Conditions: Otitis Media Acute

Contrast-Enhanced Ultrasound Scan for the Estimation of Tissue Pressure in Patients With Breast Cancer


This clinical trial studies the use of contrast-enhanced ultrasound (CEUS) in estimating tissue pressure in patients with breast cancer. Diagnostic procedures, such as CEUS, may help estimate tissue pressure noninvasively.

Conditions: Breast Carcinoma
Phase: Early Phase 1

A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma


The purpose of this study is to characterize the safety and tolerability of teclistamab when administered in different combination regimen and to identify the optimal dose(s) of teclistamab combination regimens.

Conditions: Multiple Myeloma

Prospective US Radiofrequency SUI Trial


PURSUIT: Prospective US Radiofrequency SUI Trial (VI-17-06) is a prospective, randomized, sham controlled, double blind study in premenopausal women with stress urinary incontinence. The study will be conducted in 390 subjects, randomized 2:1 with active or sham treatment. Study duration is 12 months post treatment. The primary objective is to evaluate the efficacy of the Viveve treatment, SUI protocol, in improving mild to moderate stress urinary incontinence (SUI), assessed using the 1-hour Pa ...

Conditions: Urinary Incontinence, Stress
Phase: Not Applicable

Ferumoxytol Enhanced Hyperfine Low Field Strength MRI


The purpose of this pilot study is to evaluate the feasibility of using Ferumoxytol as a contrast agent on a low field strength, portable magnetic resonance imaging (MRI) system. Participants receiving Ferumoxytol as part of routine clinical care for iron deficiency anemia will be recruited and scanned on the Hyperfine MRI system before and after their clinically scheduled intravenous infusion. Resultant images will be compared to assess signal intensity changes generated by the presence of Fero ...

Conditions: Anemia, Hemolytic

Blood Sample Collection for Experimental Blood Test to Track Liver Cancer


This study investigates if an experimental blood test can help predict how well cancer will remain under control with treatment. Ther experimental blood test involves measuring mircoRNAs. MicroRNAs are small molecules which help regulate how genes are expressed. This information may help researchers guide treatment for other patients in the future.

Conditions: Hepatocellular Carcinoma

Defactinib and VS-6766 for the Treatment of Patients With Metastatic Uveal Melanoma


This phase II trial studies the effect of combining defactinib and VS-6766 in treating patients with uveal melanoma that has spread to other places in the body (metastatic). The way cells communicate with one another (different cell signaling pathways) are overactive in uveal melanoma tumor cells. Giving defactinib together with VS-6766 may block pathways that are important for the growth of uveal melanoma cells, and may result in shrinkage or stabilization of the cancer and prolonged time to di ...

Conditions: Metastatic Uveal Melanoma

Effects of Insomnia Treatment on Metabolism in Patients With Depression


This project will examine changes in metabolism and depressive symptoms after receiving CBT-I in 30 subjects with insomnia disorder and MDD.

Conditions: Insomnia Chronic, Insomnia, Insomnia, Primary, Depression, Depressive Symptoms
Phase: Not Applicable

An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis


The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.

Conditions: Ulcerative Colitis

Onapristone and Anastrozole in Refractory Estrogen and Progesterone Positive Endometrial Cancer


The purpose of this research is to evaluate the combination treatment of onapristone, a drug that inhibits the production of progesterone, with anastrozole, a drug that inhibits the production of estrogen, for women with refractory hormone receptor positive (estrogen and progesterone receptor positive) endometrial cancer. Currently, Anastrozole is approved for the treatment of recurrent endometrial cancer with a response rate of 9%. Our hypothesis is that the combination of estrogen and progeste ...

Conditions: Endometrial Cancer

An Observational Study of Beta-Blocker Use in Patients With COPD and Acute MI


The study is a prospective, observational study of patients admitted to the BLOCK COPD network hospitals with acute AMI and COPD to determine the prevalence of COPD in patients admitted to the hospital with an acute myocardial infarction (AMI) and to characterize the phenotypic expression and severity of their underlying lung disease. Patients with will be identified via the EMR. 571 participants will be enrolled.

Conditions: Pulmonary Disease, Chronic Obstructive

PrEP Awareness, Barriers and Facilitators for PrEP Uptake, and Dosing Mechanisms on Willingness to Take PrEP Among MSM


The investigators are conducting a one and one-half year mixed-methods study to evaluate self-reported sexual risk, knowledge and barriers/facilitators of PrEP use, and preferences of oral, injectable, and implantable PrEP treatment modalities-as a function of race and age, and experience with intersectional discrimination. The first qualitative phase of our study would be conducted over the first eight months, followed by a quantitative phase that will collect data via online cross-sectional su ...

Conditions: PrEP, Discrimination, Racial, Stigma, Social