Caris Biorepository Research Protocol
Recruiting
The Biorepository for Caris Life Sciences is designed for the purpose of making quality biospecimens and associated clinical data available for research studies related to advancing precision medicine and improving care for patients. The Caris Biorepository is a repository of prospectively collected biological specimens and associated clinical and demographic data gathered from multiple sources to be stored, used and shared for research. Caris Life Sciences will maintain the data and specimens... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/21/2020
Locations: Advantage Clinical Research, Nashville, Tennessee
Conditions: Cancer
Biomarkers in Infection
Recruiting
The purpose of this investigation is to evaluate how early biomarkers of infection and inflammation perform in identifying patients at risk for poor outcome in sepsis and septic shock.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
01/14/2020
Locations: Vanderbiltt University, Nashville, Tennessee
Conditions: Sepsis, Infection, Inflammation
Pectin Use in Pediatric Intestinal Rehabilitation
Recruiting
Pediatric short bowel patients, age 6 months to 21 years old, followed in our intestinal rehabilitation clinic, will be screened for qualification in the study. If meets qualification, will be consented for the study. The study involves patients receiving green beans in their diet for three months with data collection including stooling patterns as well as labs, and then switching over to liquid pectin for three months. Again data collection will take place. The duration of the study once patien... Read More
Gender:
All
Ages:
Between 6 months and 21 years
Trial Updated:
01/09/2020
Locations: Le Bonheur Children's Hospital, Memphis, Tennessee
Conditions: Short Bowel Syndrome
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
Recruiting
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
Gender:
All
Ages:
21 years and above
Trial Updated:
12/04/2019
Locations: St. Thomas, Nashville, Tennessee
Conditions: Mitral Valve Insufficiency
Pain Control Following Sinus Surgery
Recruiting
Given the ongoing national opioid epidemic, an increased interest has developed in optimizing opioid prescribing practices of physicians, including otolaryngologists. Endoscopic sinus surgery (ESS) is one of the most commonly performed surgeries by otolaryngologists with over 250,000 ESS's performed annually in the U.S. Multiple studies have shown that, compared to the amount patients actually consume, otolaryngologists prescribe a high quantity of opioids to patients recovering from ESS). It ha... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/18/2019
Locations: Vanderbilt, Nashville, Tennessee
Conditions: Sinusitis, Opioid Use, Opioid Abuse, Narcotic Use, Otolaryngologic Disease, Postoperative Pain, Pain
Study of the Safety and Efficacy of OMS721 in Patients With Immunoglobulin A (IgA) Nephropathy
Recruiting
The purpose of this study is to evaluate the safety and efficacy of OMS721 in patients with IgA nephropathy. The study will assess proteinuria by 24-hour urine protein excretion (UPE) in g/day at 36 weeks from beginning of treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/28/2019
Locations: Omeros Investigational Site, Nashville, Tennessee
Conditions: IgA Nephropathy
Hepatocellular Research Registry
Recruiting
This is a registry of human hepatocytes (liver cells) for research purposes.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/16/2019
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Hepatocytes
Hypofractionated Image Guided Proton Therapy for Low andIntermediate Risk Prostate Cancer
Recruiting
This study is being proposed to evaluate the use of moderate hypofractionated proton therapy in low and intermediate risk prostate cancer patients. Quality of life outcomes as well as gastrointestinal and genitourinary early and late toxicities will be analyzed and compared to conventional proton therapy regimens. It is thought that this regimen will produce comparable findings and would result in substantial health care cost savings, as well as, be more convenient for patients.
Gender:
Male
Ages:
18 years and above
Trial Updated:
04/03/2019
Locations: Provision Cares Proton Therapy Center Knoxville, Knoxville, Tennessee
Conditions: Prostate Cancer
Pathobiology of Remission of Type 2 Diabetes
Recruiting
We propose to investigate effects of HP and HC weight loss diets in Newly Diagnosed T2DM (NT2DM) women and men for 6 months for remission of Type 2 Diabetes. Our long term goal is to establish a weight loss diet plan for remission of NT2DM which would be adaptable for use in physicians' clinics and metabolomics predictors for assessment of remission. The overall objective of this study is to determine if remission of NT2DM can be induced by dietary manipulation using a HP diet and the pathobiolo... Read More
Gender:
All
Ages:
Between 20 years and 50 years
Trial Updated:
02/05/2019
Locations: University of Tennessee Health Science Center, Memphis, Tennessee
Conditions: Newly Diagnosed Type 2 Diabetes, Obese
Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles
Recruiting
Study evaluating the efficacy of a micro coring device for the treatment of moderate to severe check wrinkles
Gender:
All
Ages:
Between 40 years and 70 years
Trial Updated:
01/02/2019
Locations: The Office of Brian Biesman, M.D., Nashville, Tennessee
Conditions: Wrinkle
Cerebrotendinous Xanthomatosis (CTX) Prevalence Study
Recruiting
This is an observational, multicenter study to determine the prevalence of Cerebrotendinous Xanthomatosis (CTX) in patient populations diagnosed with early-onset idiopathic bilateral cataracts. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were seen at each study site prior to that site's initiation, or by entering care at the site while the site is participating in the trial.
Gender:
All
Ages:
Between 2 years and 21 years
Trial Updated:
11/07/2018
Locations: University of Tennessee Health Science Center, Hamilton Eye Institute, Germantown, Tennessee
Conditions: Cerebrotendinous Xanthomatosis (CTX)
Prospective Outcomes Study: Vectra® DA Guided Care Compared to Usual Care
Recruiting
In this 12-month multi-center prospective, site-randomized, two-arm trial, approximately 318 biologic-naïve subjects with RA who are candidates for treatment intensification due to inadequate response to MTX monotherapy will be enrolled at up to 60 study sites.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/27/2018
Locations: University of Tennesee Health Science, Memphis, Tennessee
Conditions: Arthritis, Rheumatoid