Virginia is currently home to 1852 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Diagnostic Test to Evaluate Cancer Risk Before Surgery in Women with an Ovarian Mass
NCT06566716
Recruiting
Ovarian cancer is a serious health risk with the highest death rate among gynecological cancers. Unfortunately, it's only possible to definitively diagnose ovarian cancer after surgery, as there are no reliable tests to determine if an ovarian abnormality is cancerous or benign before surgery. Cleo Diagnostics have developed a new test that uses five biomarkers in the blood to better differentiate between benign and malignant ovarian conditions. In initial studies, this test outperformed the cu... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/02/2025
Locations: Virginia Women's Health Associates, Annandale, Virginia
Conditions: Ovarian Neoplasms
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Embolization for the Treatment of Heel Pain Secondary to Plantar Fasciitis
NCT06805942
Recruiting
This study evaluates the feasibility and safety of using Lipiodol (ethiodized oil) as an investigational embolic agent for treating pain caused by plantar fasciitis. Participants will undergo a minimally invasive procedure called plantar fascia embolization (PFE) to reduce inflammation and pain in the affected area. The study aims to assess changes in pain levels, foot function, and any potential side effects over a six-month follow-up period.
Gender:
ALL
Ages:
Between 22 years and 100 years
Trial Updated:
01/31/2025
Locations: IR Centers, Falls Church, Virginia
Conditions: Plantar Fasciitis of Both Feet
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Efficacy and Safety of Iptacopan (LNP023) in Adult Patients With Atypical Hemolytic Uremic Syndrome Naive to Complement Inhibitor Therapy
NCT04889430
Recruiting
The purpose of this Phase 3 study is to determine whether iptacopan (LNP023) is efficacious and safe for the treatment of aHUS in adult patients who are treatment naive to complement inhibitor therapy.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/31/2025
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Atypical Hemolytic Uremic Syndrome
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Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation
NCT04368559
Recruiting
The purpose of this pivotal study is to determine if intravenous Rezafungin is efficacious and safe in the prevention of invasive fungal diseases when compared to the standard antimicrobial regimen.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2025
Locations: VCU Medical Center Main Hospital, Richmond, Virginia
Conditions: Candidemia, Mycoses, Fungal Infection, Fungemia, Invasive Candidiasis, Pneumocystis, Mold Infection, Invasive Fungal Disease, Prophylaxis of Invasive Fungal Infections, Aspergillus
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The ROAM Research Study Therapy (LTOT) Version
NCT06810323
Recruiting
The purpose of this research is to test a device being developed that can see how patients use oxygen therapy over a long period of time. This study will focus on developing a new display part called ROAM module which will be attached to your oxygen source. The display will provide easily-accessible information that can show how you interact with your supplies and the oxygen machine automatically without connecting the oxygen source to the internet or other devices.
Gender:
ALL
Ages:
All
Trial Updated:
01/30/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Pulmonary Disease, Chronic Obstructive
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Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)
NCT06433219
Recruiting
The purpose of this study is to measure the effect and safety of treatment with tuvusertib combined with either niraparib or lartesertib in participants with epithelial ovarian cancer. The participants will previously have progressed while treated with a poly ADP ribose polymerase (PARP) inhibitor. The primary objective of the study is to assess the effect of the treatment in terms of overall response, i.e. whether the tumor disappears, shrinks, remains unchanged, or gets worse.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Next Oncology - Virginia, Fairfax, Virginia
Conditions: Ovarian Cancer
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Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of Membranes
NCT06273891
Recruiting
The goal of this study is to help identify the best antibiotic treatment for pregnant people when their water breaks prematurely (a condition abbreviated as PPROM). Current practice is to attempt to maintain the pregnancy until at least 34 weeks gestational age, when the risks of prematurity to the baby are lessened. Research shows that antibiotics help the pregnancy last longer, but there have been limited studies about which combination works best. Currently, both azithromycin and erythromycin... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
01/30/2025
Locations: Inova Fairfax Medical Campus, Falls Church, Virginia
Conditions: Premature Rupture of Membrane
Register for Updates
Precise Infliximab Exposure and Pharmacodynamic Control
NCT05660746
Recruiting
Approximately 3 million people in the United States are living with inflammatory bowel disease, which includes Crohn's Disease (CD). There are limited treatment options approved for use in children and adults with Crohn's disease. Physicians need better ways to inform decisions on treatment. The main reason for this research study is to determine if a computer program that calculates an individualized dose based on a patient's blood testing results (precision dosing) can better achieve the best... Read More
Gender:
ALL
Ages:
Between 6 years and 22 years
Trial Updated:
01/30/2025
Locations: Children's Specialty Group, Norfolk, Virginia
Conditions: Crohn Disease
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A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors
NCT05117476
Recruiting
CLN-619-001 is a Phase 1, open-label, multi-center study of CLN-619 alone and in combination with pembrolizumab in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Virginia Cancer Center, Fairfax, Virginia
Conditions: Advanced Solid Tumor
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Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. The purpose of this registry is to assess the long term outcomes of patients with SMA in the c... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/30/2025
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Spinal Muscular Atrophy (SMA)
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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
NCT04031677
Recruiting
This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival. After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: VCU Massey Cancer Center at Hanover Medical Park, Mechanicsville, Virginia
Conditions: Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma
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Regulating Emotions Like An eXpert Among Adolescents With ADHD
NCT06725186
Recruiting
This study consists of a randomized controlled trial assessing the acceptability, feasibility, and efficacy of the RELAX (Regulating Emotions Like An eXpert) Intervention. Following randomization, 30 families will receive the RELAX intervention and 30 families will receive psychoeducational materials as part of a control condition. Additionally, 10 families from the RELAX condition will participate in a pilot study and focus groups to give feedback on developed smartphone apps to support skill u... Read More
Gender:
ALL
Ages:
Between 11 years and 16 years
Trial Updated:
01/29/2025
Locations: Child Study Center, Blacksburg, Virginia
Conditions: RELAX Telehealth Intervention, Psychoeducational Waitlist Control, EMI Smartphone App Pilot
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