Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use
Recruiting
Bronchiolitis is the major cause of hospital admission in infants < 6 months of age and usually viruses like Respiratory syncytial virus (RSV), human metapneumo virus, Adeno virus, para-influenza virus, Rhino virus and influenza virus are the main culprit. In the US, acute bronchiolitis in infancy is responsible for approximately 150,000 hospitalizations yearly at an estimated cost of $500 million. Globally in 2005 it was estimated that at least 33.8 million were affected with RSV and in the sam... Read More
Gender:
All
Ages:
2 years and below
Trial Updated:
09/24/2019
Locations: Carilion Clinic, Roanoke, Virginia
Conditions: Bronchiolitis Acute
Immune Biomarkers Related to Bone Pathology in Patients With Type 1 Gaucher Disease
Recruiting
Bone-related problems represent the principal unmet medical need in Gaucher disease (GD). 75% of GD type 1 patients develop skeletal complications, including bone remodeling defects, osteopenia, osteoporosis, marrow infiltration, avascular necrosis, and osteolysis. However, the underlying cellular/molecular basis of bone involvement and related complications in GD are not fully known. Neither are there any bone-specific markers associated with individual bone pathology. Early diagnosis of bone d... Read More
Gender:
All
Ages:
Between 16 years and 90 years
Trial Updated:
08/13/2019
Locations: LDRTC, Fairfax, Virginia
Conditions: Gaucher Disease Type 1
Non-Contact Respiratory Rate Monitoring
Recruiting
The purpose of this study is to compare thermographic estimates of respiratory rate to manual counting (visual inspection) and thoracic impedance-based methods. Thermographic methods rely on detection of temperature changes in the nose and mouth that occur as room temperature air passes through the nose and mouth during ventilation, and may offer a non-invasive means of measuring respiratory rate without requiring any patient contact.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/15/2019
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Hypoxia
Prostate Artery Embolization (PAE) for Treatment of Benign Prostatic Hyperplasia
Recruiting
The purpose of this project is to evaluate the safety, efficacy, and feasibility of performing prostatic artery embolization (PAE) using endovascular techniques and particle embolics in men suffering from lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).
Gender:
Male
Ages:
Between 45 years and 80 years
Trial Updated:
04/15/2019
Locations: University of Virginia Health Systems, Charlottesville, Virginia
Conditions: Prostatic Hyperplasia, Benign Prostatic Hyperplasia (BPH), Prostatism, Lower Urinary Tract Symptoms (LUTS), Prostatic Hypertrophy, Hyperplasia, Male Urogenital Diseases, Genital Diseases, Male
Impact of the Use of FeelWell™ Compression Garment on Individuals With a BMI ≥35
Recruiting
To assess the effect of wearing a custom-fitted, FDA-registered, Class I device, compression garment (Obesinov, S.A.R.L.) by an individual with a BMI ≥ 35 on his/her day-to-day quality of life over a period of one year. Various measures of quality of life will be taken, including assessing an individual's level of pain, mood, self-stigma and comfort with the use of a compression garment. Additionally, to assess the impact of the compression garment on activity, strength, posture and movement of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/15/2019
Locations: Washington Center for Weight Management and Research, Inc., Shirlington, Virginia
Conditions: Obesity, Obesity, Abdominal, Mobility Limitation, Quality of Life, Back Pain, Pain, Chronic, Weight Change, Body, Inactivity, Exercise, Body Composition, Redundant Skin
The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes
Recruiting
The purpose of this study is to conduct an interventional, one year, randomized, double blind, placebo-controlled trial with Liraglutide in patients with type 2 diabetes (diabetes duration of >6 months and <10 years, HbA1c <10%) to evaluate its effects on the peripheral autonomic nervous system, as well as inflammatory markers, and measures of oxidative and nitrosative stress.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/07/2019
Locations: Strelitz Diabetes Center, Norfolk, Virginia
Conditions: Autonomic Nervous System Diseases, Sweat Gland Diseases, Diabetic Neuropathy With Neurologic Complication
Ellipsys Fistula for Hemodialysis Access
Recruiting
To report the outcomes of patients having percutaneous proximal radial artery fistula creation.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/31/2019
Locations: Richmond Vascular Center, North Chesterfield, Virginia
Conditions: ESRD
Cerebrotendinous Xanthomatosis (CTX) Prevalence Study
Recruiting
This is an observational, multicenter study to determine the prevalence of Cerebrotendinous Xanthomatosis (CTX) in patient populations diagnosed with early-onset idiopathic bilateral cataracts. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were seen at each study site prior to that site's initiation, or by entering care at the site while the site is participating in the trial.
Gender:
All
Ages:
Between 2 years and 21 years
Trial Updated:
11/07/2018
Locations: Children's Hospital of the King's Daughter, Norfolk, Virginia
Conditions: Cerebrotendinous Xanthomatosis (CTX)
Clinical Importance of Glucose Regulation in Relapsing MS
Recruiting
The purpose of this study is to assess the relationship of blood glucose levels in persons with Multiple Sclerosis (MS) who have experienced a relapse and will be receiving intravenous steroids for the relapse, to their recovery from the relapse. Steroid exposure commonly leads to elevated serum blood glucose, however, standardized monitoring of blood glucose levels in the outpatient setting is not common. The clinical impact of any associated elevated blood glucose during steroid administratio... Read More
Gender:
All
Ages:
Between 18 years and 59 years
Trial Updated:
11/05/2018
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Relapsing Remitting Multiple Sclerosis, Clinically Isolated Syndrome
Practice of Acceptance, Awareness, and Compassion in Caregiving (PAACC)
Recruiting
The Primary objective of the study is to evaluate the effectiveness of mindfulness based caregiver intervention, Practice of Acceptance, Awareness, and Compassion in Caregiving (PAACC) compared to an established cognitive behavior therapy based dementia caregiver intervention, Resources for Enhancing Alzheimer's Caregiver Health (REACH) in improving caregiver burden and quality of life of care recipient.
Gender:
All
Ages:
All
Trial Updated:
09/10/2018
Locations: Salem VAMC, Salem, Virginia
Conditions: Dementia
Prospective Outcomes Study: Vectra® DA Guided Care Compared to Usual Care
Recruiting
In this 12-month multi-center prospective, site-randomized, two-arm trial, approximately 318 biologic-naïve subjects with RA who are candidates for treatment intensification due to inadequate response to MTX monotherapy will be enrolled at up to 60 study sites.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/27/2018
Locations: Arthritis Clinic of Northern VA, PC, Arlington, Virginia
Conditions: Arthritis, Rheumatoid
A Registry Study of Breast Microseed Treatment
Recruiting
For women diagnosed with early stage breast cancer, lumpectomy followed by radiation is a common treatment option. Radiation treatment is typically delivered to the whole breast, five times per week, for anywhere from 3 to 8 weeks. The radiation helps kill any cancer cells that may have been left over following the surgery but causes skin burns. Many studies have demonstrated that radiation to the whole breast is not necessary, that it can be delivered to a portion of the breast where the cancer... Read More
Gender:
Female
Ages:
50 years and above
Trial Updated:
03/16/2018
Locations: Mary Washington Hospital, Fredericksburg, Virginia
Conditions: Breast Neoplasms