Virginia is currently home to 1872 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Evaluation of the Safety and Pharmacokinetics of Oleander 4X in Healthy Volunteers
Recruiting
The homeopathic medicine, Oleander 4X HPUS is indicated for temporary relief of symptoms associated with flu, such as muscle or body aches, headaches, chills and fever, cough, and congestion. The primary purpose of this study is to assess the safety of Oleander 4X HPUS in health male and female subjects compared to a placebo. This is a randomized, double blind, placebo-controlled Phase I Proof of Concept clinical trial to evaluate the safety and efficacy of OLEANDER 4X HPUS in Healthy Volunteers... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/17/2020
Locations: Dr. William Ball offices, Roanoke, Virginia
Conditions: Flu-like Symptoms
Hyperpolarized Xenon-129 MR Imaging of the Lung
Recruiting
Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine phenotypes similar to those of human COPD. Recently, "spiked" vape juice has been linked to severe lung damage. Unfortunately, the effects of e-cigarettes on the human lungs are still poorly understood, especially in healthy... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/09/2020
Locations: Snyder Building 480 Ray C. Hunt Drive, Charlottesville, Virginia
Conditions: E-Cig Use
4D-MRI for Precision Medicine
Recruiting
The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!) This new way of medical imaging is being developed to help cancer patients undergoing radiation therapy. Radiation therapy is used to treat cancerous tumors. For r... Read More
Gender:
All
Ages:
Between 18 years and 82 years
Trial Updated:
12/07/2020
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Healthy Volunteers, Liver Cancer, Lung Cancer
Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
Recruiting
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/02/2020
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Chronic Obstructive Pulmonary Disease
Spinal Cord Injury Registry - North American Clinical Trials Network
Recruiting
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI). Information will be collected on the natural history of SCI and course of treatment through the first 12 months from the date of injury or long as medically indicated. Data collected includes imaging information from CT or MRI scans, neurological a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/22/2020
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Spinal Cord Injury
Focal Salvage HDR Brachytherapy for Locally Recurrent Prostate Cancer in Patients Treated With Prior Radiotherapy
Recruiting
This purpose of this study is to evaluate the safety and effectiveness of a technique called focal high-dose-rate (HDR) brachytherapy as treatment for prostate cancer that has come back in the prostate after prior radiotherapy. The study will examine the safety and efficacy of the treatment. The type of radiation that participants in this research will receive is targeted directly at the areas of the prostate where recurrent disease is evident, while avoiding treatment of the normal appearing pr... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
05/29/2020
Locations: University of Virginia School of Medicine, Charlottesville, Virginia
Conditions: Locally Recurrent Prostate Cancer
Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML
Recruiting
A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treat... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/21/2020
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Newly Diagnosed FLT3 Mutated AML
FDG and FDOPA PET Demonstration of Functional Brain Abnormalities
Recruiting
The purpose of this pilot study will be to conduct a clinical trial using a time-of-flight PET scanner and MRI scanner to test an improved method for differentiating tumor recurrence from radiation necrosis in glioblastoma patients. We will attempt to do so by performing a static and dynamic FDG-PET scan, a static and dynamic FDOPA-PET scan, and a multiparametric MRI scan - then comparing the results with surgical pathology and static FDG-PET scans. We hypothesize that the new quantitative kinet... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2020
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Glioblastoma
Mechanistic Clinical Trial of Advanced Imaging for CRT
Recruiting
This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.
Gender:
All
Ages:
Between 20 years and 90 years
Trial Updated:
02/04/2020
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Heart Failure, Systolic
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
Recruiting
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
Gender:
All
Ages:
21 years and above
Trial Updated:
12/04/2019
Locations: Valley Health System | Virginia, Winchester, Virginia
Conditions: Mitral Valve Insufficiency
NSAIDs vs. Coxibs in the Presence of Aspirin
Recruiting
The objectives of this single site, randomized, crossover study is to evaluate the pharmacodynamic interactions between aspirin, NSAIDs and Coxibs with respect to platelet function, biomarkers of inflammation and endothelial function.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
10/04/2018
Locations: Inova Heart and Vascular Institute, Falls Church, Virginia
Conditions: Rheumatoid Arthritis, Cardiovascular Diseases
A Registry Study of Breast Microseed Treatment
Recruiting
For women diagnosed with early stage breast cancer, lumpectomy followed by radiation is a common treatment option. Radiation treatment is typically delivered to the whole breast, five times per week, for anywhere from 3 to 8 weeks. The radiation helps kill any cancer cells that may have been left over following the surgery but causes skin burns. Many studies have demonstrated that radiation to the whole breast is not necessary, that it can be delivered to a portion of the breast where the cancer... Read More
Gender:
Female
Ages:
50 years and above
Trial Updated:
03/16/2018
Locations: Mary Washington Hospital, Fredericksburg, Virginia
Conditions: Breast Neoplasms