Virginia is currently home to 1880 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Water Intake and Weight Control in Older Adults
NCT05843318
Recruiting
This study is a randomized controlled intervention trial in adults aged 50+ years with overweight or obesity, which will compare three groups with different diet prescriptions: 1) pre-meal water consumption (500 ml, before each main meal) with a hypocaloric diet; 2) 1500 ml water consumed throughout the day with a hypocaloric diet; 3) hypocaloric diet with no instructions regarding water consumption. Smart water bottles will objectively assess water intake timing and volume. Urine osmolality, ur... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
12/01/2023
Locations: Virginia Tech, Blacksburg, Virginia
Conditions: Overweight and Obesity
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Ph 1/2 Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration
NCT05315700
Recruiting
The purpose of this study is to establish the recommended Phase 2 dose (RP2D) and/or maximum tolerated dose (MTD), safety, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of ORIC-114 as a Single Agent or in Combination with Chemotherapy when administered to patients with advanced solid tumors harboring an EGFR or HER2 alteration.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/01/2023
Locations: Next Oncology, Fairfax, Virginia
Conditions: Solid Tumors
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A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
NCT05789069
Recruiting
The purpose of this study is to test the safety and tolerability of HFB200603 as a single agent and in combination with tislelizumab in patients with advanced cancers. There are two parts in this study. During the escalation part, groups of participants will receive increasing doses of HFB200603 as a monotherapy or in combination with tislelizumab until a safe and tolerable dose of HFB200603 as a single agent or combination therapy is determined. During the expansion part, participants will take... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: New Experimental Therapeutics of Virginia - NEXT Oncology, Fairfax, Virginia
Conditions: Renal Cell Carcinoma, Melanoma, Non Small Cell Lung Cancer, Gastric Cancer, Colorectal Cancer
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Stroke Thrombectomy and Aneurysm Registry
NCT04994756
Recruiting
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood vessels, abnormal formation of blood vessels, tearing of vein, and bleeding in the brain. This information is used to help predict outcomes that undergo an operation for treatment of the above-listed brai... Read More
Gender:
All
Ages:
Between 1 year and 120 years
Trial Updated:
11/30/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Stroke, Thromboses, Intracranial, Aneurysm, Brain
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Optimizing Pain Self-Management in Total Knee Arthroplasty
NCT06038240
Recruiting
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive emotion generative practice - savoring meditation, which has been demonstrated to reduce pain in experimental laboratory settings, enhanced with a pain neuroscience education component about reward syste... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
11/29/2023
Locations: Fontaine Research Park, Charlottesville, Virginia
Conditions: Osteo Arthritis Knee, Knee Pain Chronic, Surgery
Register for Updates
Automated Insulin Delivery (AID) for Basal Insulin Titration in Type 2 Diabetes
NCT06024928
Recruiting
The purpose of this clinical trial is to test the safety and feasibility of using an Automated Insulin Device (AID) in people with Type 2 Diabetes under basal insulin injections to achieve safe and fast basal insulin titration. Participants will be randomized to either the control group or the experimental group. If in the experimental group, the participant will use an insulin pump with Control-IQ Technology (Tandem Diabetes Care) for ten days. Researchers will compare the glycemic control of t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/29/2023
Locations: University of Virginia Center for Diabetes Technology, Charlottesville, Virginia
Conditions: Type 2 Diabetes
Register for Updates
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
NCT06009276
Recruiting
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle. Participants will complete all or some of the following: A mouth swab to assess the bacteria in their mouths. Produce a saliva sample into a tube. Cycle on a bike... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: UVA Student Health and Wellness Building, Charlottesville, Virginia
Conditions: Heart Failure, Systolic, Heart Failure, Diastolic, Peripheral Arterial Disease, Overweight and Obesity
Register for Updates
PENG vs FICB for Hip Fracture in ED Patients
NCT05505604
Recruiting
Regional anesthesia for hip fractures has been shown to decrease rates of delirium in elderly patients with hip fractures as well as improve pain compared to systemic opioids. The Pericapsular Nerve Group (PENG) block has recently received attention as an alternative approach to femoral nerve block and Fascia Iliaca Compartment Block (FICB). The investigators seek to evaluate if there is a difference between the PENG and FICB in terms of efficacy of pain control in ED patients presenting with hi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: University of Virginia Medical Center, Charlottesville, Virginia
Conditions: Femoral Neck Fractures, Intertrochanteric Fractures
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The Group Risk Reduction Intervention Therapy (GRRIT) Project
NCT05401838
Recruiting
Investigators will evaluate a group format adaptation of Brief Cognitive-Behavioral Therapy for Suicide (i.e., G-BCBT) on suicide ideation (Aim 1), ability to use coping strategies (Aim 2), and overall mental health (exploratory analysis). The combination of tailored means safety counseling and training in evidence-based emotion regulation and cognitive flexibility skills delivered via a 12-session group therapy treatment will decrease service members' overall suicide risk. The group format will... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
11/28/2023
Locations: Naval Medical Center Portsmouth, Portsmouth, Virginia
Conditions: Suicidal Ideation, Suicide, Attempted, Coping Skills, Depression, Anxiety, PTSD
Register for Updates
The Use of Memantine for Prevention of Alzheimer's Disease
NCT05063851
Recruiting
As the US population ages, the prevalence of dementia is increasing, and Alzheimer's Disease (AD) is the most prevalent one. Solving the Alzheimer's Disease (AD) epidemic is likely to require preventive therapy beginning many years before symptoms are expected to be evident in at-risk individuals. AD is caused by the dysfunction, loss of synapses, and eventual neuronal death, which may occur up to 25 years before clinical symptoms appear. This study, based off of pre-clinical data, seeks to asse... Read More
Gender:
All
Ages:
Between 50 years and 65 years
Trial Updated:
11/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Alzheimer Disease
Register for Updates
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion During Exercise in Patients With PAD
NCT05036213
Recruiting
Peripheral arterial disease (PAD) is a highly prevalent and costly condition. Intermittent claudication (IC), defined as ischemic leg pain that occurs with walking, results in functional impairment, reduced daily physical activity, and a lower quality of life. Although the mechanisms contributing to functional impairment are not fully delineated, current evidence suggests that the uncoupling of skeletal muscle cellular metabolism from tissue perfusion may be responsible for exercise intolerance.... Read More
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
11/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Peripheral Arterial Disease, Peripheral Vascular Diseases
Register for Updates
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
NCT04951219
Recruiting
A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)
Gender:
All
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: Bon Secours Liver Institute of Richmond, Richmond, Virginia
Conditions: Non-Alcoholic Fatty Liver Disease
Register for Updates