Virginia is currently home to 1850 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation
NCT03193151
Recruiting
INTERLIVER is a prospective observational study of the relationship of the molecular phenotype of 300 liver transplant biopsies to the histologic phenotype and the clinical features and outcomes. A segment of a biopsy performed as standard-of-care for indications, or by center protocol, will be used for gene expression study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: Transplant Surgery, VCU Medical Center, Richmond, Virginia
Conditions: Liver Dysfunction
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GDM: Insulin with or Without Metformin?
NCT06781775
Recruiting
This will be a randomized trial of patients with gestational diabetes who start hypoglycemic therapy with metformin but eventually require insulin. It will examine whether continuing metformin when adding insulin versus discontinuing metformin when insulin is added is beneficial. The investigators hypothesize that continuing metformin will reduce the needed insulin dosage and improve maternal and neonatal outcomes in these patients.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
01/13/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Gestational Diabetes
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A Clinical Trial to Assess COM503 in Participants with Advanced Solid Malignancies
NCT06759649
Recruiting
The overall goal of this first-in-human (FIH) clinical trial is to learn about the safety and dosing of COM503 when given alone or in combination with zimberelimab in participants with advanced solid tumors. The primary objectives of this study are: * To assess the safety and tolerability of COM503 as monotherapy and COM503 in combination with zimberelimab in participants with advanced solid tumors. * To identify the maximum tolerated dose (MTD) / maximum administered dose (MAD) and/or the rec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: NEXT Oncology Virginia, Fairfax, Virginia
Conditions: Neoplasm, Cancer, Malignant Tumors
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Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset
NCT05685745
Recruiting
The goal of the Tiny Baby Collaborative Multicenter Inventory of Neonatal-Perinatal Interventions (MINI) minimum dataset is to serve as a registry detailing the outcomes and practices for all deliveries and infants admitted to intensive care at 22-23 weeks' gestation at participating hospitals.
Gender:
ALL
Ages:
Between 0 years and 1 year
Trial Updated:
01/10/2025
Locations: Children's Hospital of Richmond, Richmond, Virginia
Conditions: Infant, Extremely Premature, Obstetric Labor, Premature, Premature Birth, Intensive Care, Neonatal, Intensive Care Units, Neonatal
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Valuation in Depressed Mood, Anhedonia, and Anxiety
NCT05384158
Recruiting
This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.
Gender:
ALL
Ages:
Between 25 years and 50 years
Trial Updated:
01/10/2025
Locations: Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia
Conditions: Neurobehavioral Components of Reward and Loss Valuation
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Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure
NCT05177822
Recruiting
Patients who have a heart attack are at high risk for future development of heart failure ('weakening of the heart'). The researchers believe that the reaction of the heart muscle to injury (inflammation) during a heart attack may be contributing to the risk of heart failure. The current study will test the ability of an anti-inflammatory medicine (anakinra) to block the inflammation in the body during and after a heart attack.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/10/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Heart Failure
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Cardiac Implantable Electronic Device (CIED) Research Study
NCT05061862
Recruiting
The study is designed to collect data on Cardiovascular Implantable Electronic Device (CIED) information, implant procedure details, and/or patient characteristics to support development of future CIED products and procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/10/2025
Locations: University of Virginia Medical Center, Charlottesville, Virginia
Conditions: Arrhythmias, Cardiac, Bradycardia, Tachycardia
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Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1
NCT04916327
Recruiting
The purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
01/10/2025
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Peripheral Vascular Diseases
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Clinical Transcriptomics in Systemic Vasculitis (CUTIS)
NCT03004326
Recruiting
Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
01/10/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis, Eosinophilic Granulomatosis With Polyangiitis (EGPA), IgA Vasculitis, Isolated Cutaneous Vasculitis, Granulomatosis With Polyangiitis (GPA), Microscopic Polyangiitis (MPA), Polyarteritis Nodosa (PAN), Urticarial Vasculitis, Vasculitis
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Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention
NCT00733590
Recruiting
The overall hypothesis of this study is that subtle interactions between structural (substrate) and functional (trigger) abnormalities of the heart, some of which are genetically-determined, can be used to identify patients at high risk of sudden cardiac death (SCD). Such information may be used to better define patients most likely to benefit from replacement of an internal defibrillator (ICD). The prospective, observational study to enroll, categorize and follow patients who receive an ICD pul... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/10/2025
Locations: Virginia Commonwealth University School of Medicine, Richmond, Virginia
Conditions: Heart Failure, Congestive, Death, Sudden, Cardiac, Arrhythmia, Cardiomyopathies
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Low-Intensity Focused Ultrasound and the Complex Patient
NCT06297200
Recruiting
Studying the effects of Low Intensity Focused Ultrasound (LIFU) on measures of pain, craving, and anxiety in a complex patient population.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/09/2025
Locations: Fralin Biomedical Research Institute at VTC, Roanoke, Virginia
Conditions: Opioid Use Disorder, Chronic Pain, Anxiety Disorder
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BEETroot Juice to Reverse Functional Impairment in PAD
NCT05624125
Recruiting
The BEET PAD Trial is a multi-centered double-blind randomized clinical trial designed to determine whether beetroot juice, compared to placebo, improves six-minute walk distance at four month follow-up in people with lower extremity peripheral artery disease (PAD). Investigators hypothesize that by simultaneously increasing lower extremity perfusion, gastrocnemius muscle mitochondrial activity, and myofiber health and regeneration, beetroot juice will significantly improve walking performance i... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
01/09/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Peripheral Artery Disease
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