Virginia is currently home to 1881 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy
NCT00680264
Recruiting
The purpose of this study is to determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy.
Gender:
All
Ages:
Between 8 years and 21 years
Trial Updated:
11/20/2023
Locations: Kluge Children's Rehab. Ctr., Charlottesville, Virginia
Conditions: Cerebral Palsy, Scoliosis
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Use of Harmonic Scalpel to Decrease Lymphatic and Chest Tube Drainage After Lymph Node Dissection With Lobectomy.
NCT00591552
Recruiting
In an effort to elucidate whether the Harmonic Scalpel will improve sealing lymphatics and decrease lymphatic drainage thereby decreasing the length of time that chest tubes are required and minimizing length of stay; the Harmonic Scalpel will be compared to a control group which uses electrocautery. This study will assess these two different methods to determine if there is a notable decrease in the amount of drainage with one versus the other.
Gender:
All
Ages:
Between 20 years and 75 years
Trial Updated:
11/20/2023
Locations: Sentara Norfolk General Hospital/Sentara Heart Hospital, Norfolk, Virginia
Conditions: Lung Cancer
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Left vs Left Randomized Clinical Trial
NCT05650658
Recruiting
The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g., lead dislodgement, infection) relative to standard of care biventricular pacing in patients with heart failure due to left ventricular systolic dysfunction (LVEF≤50%) and with... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/19/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB, RBBB, Intraventricular Conduction Delay, Pacing-Induced Cardiomyopathy
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Study of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation
NCT05737706
Recruiting
A Phase 1/2 study of MRTX1133 in solid tumors harboring a KRAS G12D mutation.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/17/2023
Locations: NEXT Oncology Virginia, Fairfax, Virginia
Conditions: Solid Tumor, Advanced Solid Tumor, Non-small Cell Lung Cancer, Colo-rectal Cancer, Pancreatic Adenocarcinoma
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A Study of ZL-1211 in Patients With Advanced Solid Tumor
NCT05065710
Recruiting
This study is a Phase I/II, open-label, dose escalation, and cohort expansion study designed to characterize the safety, tolerability, pharmacokinetic (PK), pharmacodynamics (PD), immunogenicity, and preliminary antitumor activity of ZL-1211 administered by IV infusion on a every 2 weeks (Q2W) schedule.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/17/2023
Locations: Zai Lab Site 2023, Fairfax, Virginia
Conditions: Advanced Solid Tumor
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Study to Evaluate EP547 in Subjects With Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis
NCT05525520
Recruiting
This phase 2 trial will evaluate the effects of EP547 in subjects with cholestatic pruritus due to Primary Biliary Cholangitis (PBC) or Primary Sclerosing Cholangitis (PSC)
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
11/16/2023
Locations: Digestive & Liver Disease Specialists, Norfolk, Virginia
Conditions: Pruritus
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Head and Intraocular Trauma Tool for the Identification of Mild Traumatic Brain Injury
NCT05092295
Recruiting
Rebion has developed a device, the Rebion trauma tool (referred to as the head and intraocular trauma tool, or "HITT"), that detects ocular fixation and alignment using a binocular retinal scan. Preliminary data obtained from hospitalized patients with a clinically-confirmed traumatic brain injury (TBI) and uninjured controls indicates that the device can detect changes in ocular fixation, alignment, and saccades that are related to brain injury. This study seeks to evaluate the ability of the R... Read More
Gender:
All
Ages:
Between 13 years and 45 years
Trial Updated:
11/16/2023
Locations: Carilion Roanoke Memorial Hospital, Roanoke, Virginia
Conditions: Brain Injuries, Traumatic
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PrEP Intervention Among Black Sexual Minority Men
NCT06141408
Recruiting
The goal of the proposed research is to design a peer-based community intervention focused on addressing internalized homophobia, internalized racism, HIV stigma, and peer BSMM support to increase PrEP initiation among BSMM in Prince George's County, MD. Participants will attend intervention events focused on stigma reduction and building community among Black queer men. Researchers will compare intervention and control group participants to see if there in a difference in PrEP initiation and ad... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: George Mason University, Fairfax, Virginia
Conditions: Hiv, Mental Health Issue, Support, Family
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Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease
NCT05365490
Recruiting
The study objective is to evaluate real world usage of the ENROUTE Transcarotid Stent when used with the ENROUTE Transcarotid Neuroprotection System in patients at standard risk for adverse events from carotid endarterectomy
Gender:
All
Ages:
Between 18 years and 79 years
Trial Updated:
11/15/2023
Locations: Sentara, Norfolk, Virginia
Conditions: Carotid Artery Diseases
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Niraparib and Neratinib in Advanced Solid Tumors With Expansion Cohort in Advanced Ovarian Cancer
NCT04502602
Recruiting
To determine the recommended phase 2 dose (RP2D) of niraparib and neratinib in combination in patients with advanced solid tumors during Phase 1. To evaluate clinical benefit (≥4-month progression-free survival [PFS]) of niraparib and neratinib in patients with platinum-resistant ovarian cancer in Phase 1b.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Advanced Solid Tumor, Ovarian Cancer
Register for Updates
Cryospray Therapy for Benign Airway Stenosis
NCT06085209
Recruiting
This is a clinical evaluation to assess the effectiveness of cryospray therapy used in addition to current standard of care endoscopic therapies in preventing short term recurrent airway stenosis with a multicentric outcome evaluation. The investigators hypothesize that the addition of SCT to standard endoscopic treatment of benign airway stenosis will result in decreased stenosis recurrence at 6 months as estimated by quantitative radiologic assessment of the stenotic volume.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/14/2023
Locations: Virgnia Commonwealth University, Richmond, Virginia
Conditions: Stenosis Trachea
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Testing the Response to the Anti-cancer Drug, Triapine, in Uterine Cancers Using Markers From the Tissue at the Time of Hysterectomy
NCT04494113
Recruiting
This early phase I trial investigates the response to the anti-cancer drug, triapine, in uterine cancers by using markers from tissue samples at the time of removal of the uterus, ovaries, and fallopian tubes (hysterectomy and bilateral salpingo-oophorectomy). Triapine may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Adding triapine to the usual approach of surgery followed by chemotherapy alone or in combination with radiation therapy may help to slow t... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/14/2023
Locations: Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Conditions: Endometrial Serous Adenocarcinoma
Register for Updates