Virginia is currently home to 1823 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)
NCT05500222
Recruiting
This study will determine the effect of oral 80 mg resmetirom administered once daily on participants with well-compensated non-alcoholic steatohepatitis (NASH) cirrhosis by measuring the time to experiencing a Composite Clinical Outcome event.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/21/2024
Locations: GI Select Health Research, Richmond, Virginia
Conditions: NASH, Cirrhosis, Liver
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The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use in Conjunction With VISITAG SURPOINT Module for the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation.
NCT06324201
Recruiting
Observational, multi-center, non-randomized, post-market study. This is a nested sub-study of the REAL AF Registry. Consecutive symptomatic drug refractory paroxysmal atrial fibrillation (PAF) patients from the registry will be screened for enrollment to this sub-study per inclusion and exclusion criteria.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Centra Health, Inc.dba Stroobants Cardiovascular Center, Lynchburg, Virginia
Conditions: Paroxysmal Atrial Fibrillation
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iSIPsmarter: A Pilot RCT to Evaluate a Web-based Behavioral Intervention to Reduce Sugary Beverages Among Black Adults
NCT06184737
Recruiting
The proposed pilot randomized controlled trial (RCT) will enroll 24 Black adults. The overall goal is to examine the preliminary efficacy of iSIPsmarter in a 2 group \[iSIPsmarter vs. static Patient Education (PE) website\] by 4 assessment (Pre, 3-, 6- and 18-month follow-up) design. The generated pilot data will allow us to better understand efficacy and engagement outcomes among Black participants. We anticipate trends that iSIPsmarter will be more efficacious at reducing SSB consumption than... Read More
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
03/19/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Diet Habit, Sugar-Sweetened Beverages
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Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors
NCT05280314
Recruiting
This is a multicenter, multi-arm trial evaluating anti-tumor activity, safety, and immune infiltration of IO102-IO103 in combination with pembrolizumab KEYTRUDA® as neoadjuvant and post-surgery treatment. This proof-of-concept trial will include patients with resectable tumors in at least 2 indications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: Massey Cancer Center, Richmond, Virginia
Conditions: Melanoma, Squamous Cell Carcinoma of Head and Neck
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A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT06322693
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Fairfax, Virginia
Conditions: Neoplasms
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Biomarkers Related to Bone in Pediatric Gaucher Disease
NCT06116071
Recruiting
Aims of the observational study is to establish novel blood-based biomarkers for grading bone disease in pediatric patients with Gaucher disease (GD). Patients with clinically confirmed GD: deficient GCase enzyme activity and corresponding genetic analysis will be eligible for enrollment. Levels of Lyso-Gb1, chitotriosidase, and CCL18 will be established for future bone biomarkers correlation analysis. Skeletal involvement will be assessed using standard clinical diagnostic tools, such as skelet... Read More
Gender:
ALL
Ages:
Between 5 years and 21 years
Trial Updated:
03/12/2024
Locations: Lysosomal and Rare disorder research and treatment center, Fairfax, Virginia
Conditions: Gaucher Disease, Bone Diseases
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Blood-brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
NCT05317858
Recruiting
The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type 2.0/2.1 for the treatment of NSCLC brain metastases in patients who are undergoing planned pembrolizumab monotherapy.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/12/2024
Locations: Johnston Willis Hospital, Richmond, Virginia
Conditions: Brain Tumor
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Telemedicine Use in Preoperative Counseling for Endometrial Cancer Survivors
NCT05712668
Recruiting
To determine whether telemedicine is an acceptable addition to pre-operative counseling, compared to face-to-face communication alone for patients with endometrial cancer.
Gender:
FEMALE
Ages:
All
Trial Updated:
03/08/2024
Locations: Carilion Clinic, Roanoke, Virginia
Conditions: Telemedicine, Counseling
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The Natural History Study of Patients With Sanfilippo Disease(s) (MPS3)
NCT05705674
Recruiting
The natural history study of patients with Sanfilippo disease(s) (MPS3)
Gender:
ALL
Ages:
Between 5 years and 99 years
Trial Updated:
03/07/2024
Locations: LDRTC, Fairfax, Virginia
Conditions: Sanfilippo Syndrome, MPS3
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A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567
Recruiting
The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this study is to collect the long-term safety of vedolizumab in children with UC or CD.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/05/2024
Locations: Carilion Children's Tanglewood Center, Roanoke, Virginia
Conditions: Ulcerative Colitis, Crohn's Disease
Register for Updates
Evaluation of Symphony™ Posterior Cervical System for Surgical Treatment of Adult Cervical Deformity
NCT04912674
Recruiting
Multi-center, prospective, non-randomized study to evaluate Symphony™ Posterior Cervical System in the setting of surgical treatment of adult cervical deformity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Cervical Deformity
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Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional Failure in Long Posterior Spinal Fusion Constructs for Adult Patients
NCT04888104
Recruiting
Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional Failure in Long Posterior Spinal Fusion Constructs for Adult Patients
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Adult Spinal Deformity, Scoliosis, Kyphosis
Register for Updates