Virginia is currently home to 1818 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Patient Augmented Reality and Vibratory Array Otorhinolaryngology Procedures
NCT06227039
Recruiting
In-office procedures (IOPs) are a cost-effective, and safe alternative to many operating room procedure, with benefits such as reduced anesthesia risk. One of the major causes of failed in-office procedures or requirement of conversion to the operating room is poor patient tolerance. Vibration and augmented reality (AR) can be used as non-pharmacologic treatment options to treat patient anxiety and pain by using the physiology proposed by the gate-way theory of pain as well as distraction. This... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2024
Locations: UVA Fontaine Research Park Building 415, Charlottesville, Virginia
Conditions: Pain, Acute, Vocal Fold Polyp, Vocal Cord Paralysis, Laryngeal Neoplasms
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Voice Rest and Injection Laryngoplasty
NCT05542550
Recruiting
The purpose of this study is to evaluate the subjective, objective, and aerodynamic impact of voice rest following injection augmentation and compare the outcomes to patients with no post-procedure voice restrictions.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
01/17/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Vocal Cord Paralysis
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A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS)
NCT05829226
Recruiting
A Phase 1 Open-label, Multi-center Study of the Safety, Pharmacokinetics (PK), and Anti-tumor Activity of LYT- 200 in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML), or with Relapsed/refractory, High-risk Myelodysplastic Syndrome (MDS)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2024
Locations: Virginia Commonwealth University Medical Center, Richmond, Virginia
Conditions: AML, Adult Recurrent, MDS
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C-Brace Prospective Registry
NCT04640584
Recruiting
To gather prospective safety and effectiveness data for the C-Brace System following the standard of care.
Gender:
ALL
Ages:
All
Trial Updated:
01/09/2024
Locations: Hunter Holmes McGuire VA, Richmond, Virginia
Conditions: Pareses, Lower Extremity
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Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
NCT04591392
Recruiting
Evaluation of the safety and efficacy of the reSept ASD Occluder to treat patients with clinically significant secundum atrial septal defect
Gender:
ALL
Ages:
84 years and below
Trial Updated:
12/21/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities, Cardiovascular Diseases, Heart Diseases, Congenital Abnormalities
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Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)
NCT03883412
Recruiting
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and muscle capillary blood volume, improves vascular function in the larger conduit vessels, and enhances insulin's metabolic action in humans with Type 2 diabetes. Subjects will be randomized to one of the three groups: exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the base... Read More
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
12/19/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Type2 Diabetes
Register for Updates
Modifiers of Disease Severity in Cerebral Cavernous Malformations
NCT01764529
Recruiting
Cerebral cavernous malformations (CCMs) are clusters of abnormal blood vessels in the brain and spine. CCMs can bleed and cause strokes, seizures, and headaches. CCMs are often caused by an inherited gene mutation (alteration) in one of three CCM genes (CCM1, CCM2, or CCM3). There is a wide range of disease severity even among family members with this disease, though the natural history has not been clearly described for this particular population. This study will continue to enroll and follow... Read More
Gender:
ALL
Ages:
All
Trial Updated:
12/19/2023
Locations: Alliance to Cure Cavernous Malformation, Charlottesville, Virginia
Conditions: Cavernous Angioma, Familial, Cerebral Cavernous Malformations, Cerebral Cavernous Hemangioma
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TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery
NCT04197687
Recruiting
This phase II trial studies how well TPIV100 and sargramostim work in treating patients with HER2 positive, stage II-III breast cancer that has residual disease after chemotherapy prior to surgery. It also studies why some HER2 positive breast cancer patients respond better to chemotherapy in combination with trastuzumab and pertuzumab. TPIV100 is a type of vaccine made from HER2 peptide that may help the body build an effective immune response to kill tumor cells that express HER2. Sargramostim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: Inova Fairfax Hospital, Falls Church, Virginia
Conditions: Breast Adenocarcinoma, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage III Breast Cancer AJCC v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIB Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7
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Evaluation of the Effectiveness of Nail Genesis DLSO Product for Onychomycosis
NCT06074315
Recruiting
This is a Pre-IDE, prospective, multicenter, randomized, parallel-group, double-blind, vehicle- controlled study to evaluate safety and effectiveness of Nail Genesis DLSO Product for the treatment of DLSO compared with vehicle in infected great toenails in a total of 338 males and non-pregnant, non-lactating, females between 18 and 65 years of age (inclusive). Subjects will be randomized in a 2:1 ratio to receive either Nail Genesis DLSO Product or vehicle. Subject eligibility will be determine... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/06/2023
Locations: The Education & Research Foundation, Inc., Lynchburg, Virginia
Conditions: Distal Lateral Subungual Onychomycosis, Onychomycosis
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Management of Antiplatelet Regimen During Surgical Procedures
NCT03981835
Recruiting
There are key differences today in clinical practice regarding perioperative management of post-PCI patients on DAPT undergoing NCS. Moreover, there are significant differences between bridging agents, and improved safety of current-generation DES. Given the significant limitations of current studies a well-designed registry to study current U.S. practice patterns and the bleeding or ischemic risks associated with the various perioperative DAPT management strategies including bridging and no bri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Mary Washington Hospital, Fredericksburg, Virginia
Conditions: Cardiac Surgery, Surgery, Percutaneous Coronary Intervention, Surgery--Complications
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Optimizing Pain Self-Management in Total Knee Arthroplasty
NCT06038240
Recruiting
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive emotion generative practice - savoring meditation, which has been demonstrated to reduce pain in experimental laboratory settings, enhanced with a pain neuroscience education component about reward syste... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/29/2023
Locations: Fontaine Research Park, Charlottesville, Virginia
Conditions: Osteo Arthritis Knee, Knee Pain Chronic, Surgery
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Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
NCT06009276
Recruiting
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle. Participants will complete all or some of the following: * A mouth swab to assess the bacteria in their mouths. * Produce a saliva sample into a tube. * Cycle on a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: UVA Student Health and Wellness Building, Charlottesville, Virginia
Conditions: Heart Failure, Systolic, Heart Failure, Diastolic, Peripheral Arterial Disease, Overweight and Obesity
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