Virginia is currently home to 1850 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Inflammatory Pathways and Cardiac Growth Factors Associated With Fabry Disease Cardiomyopathy
NCT04724083
Recruiting
In Fabry disease (FD), α-galactosidase A deficiency leads to the accumulation of globotriaosylceramide (Lyso-Gb3 and Gb3), triggering a pathologic cascade that causes progressive damage to multiple organs, including the heart. The heart is one of the organs that is very sensitive to the deficiency of α-galactosidase A. There is a subgroup of patients with significant residual α-galactosidase activity and a phenotype with primary cardiac involvement, occasionally referred as "cardiac variant." Th... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/25/2021
Locations: Lysosomal and Rare disorder research and treatment center, Fairfax, Virginia
Conditions: Fabry
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An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04718818
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Richmond, Virginia
Conditions: Ulcerative Colitis
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Evaluation of the Safety and Pharmacokinetics of Oleander 4X in Healthy Volunteers
NCT04674709
Recruiting
The homeopathic medicine, Oleander 4X HPUS is indicated for temporary relief of symptoms associated with flu, such as muscle or body aches, headaches, chills and fever, cough, and congestion. The primary purpose of this study is to assess the safety of Oleander 4X HPUS in health male and female subjects compared to a placebo. This is a randomized, double blind, placebo-controlled Phase I Proof of Concept clinical trial to evaluate the safety and efficacy of OLEANDER 4X HPUS in Healthy Volunteers... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/17/2020
Locations: Dr. William Ball offices, Roanoke, Virginia
Conditions: Flu-like Symptoms
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Hyperpolarized Xenon-129 MR Imaging of the Lung
NCT04662658
Recruiting
Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine phenotypes similar to those of human COPD. Recently, "spiked" vape juice has been linked to severe lung damage. Unfortunately, the effects of e-cigarettes on the human lungs are still poorly understood, especially in healthy... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/09/2020
Locations: Snyder Building 480 Ray C. Hunt Drive, Charlottesville, Virginia
Conditions: E-Cig Use
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4D-MRI for Precision Medicine
NCT04657042
Recruiting
The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!) This new way of medical imaging is being developed to help cancer patients undergoing radiation therapy. Radiation therapy is used to treat cancerous tumors. For r... Read More
Gender:
All
Ages:
Between 18 years and 82 years
Trial Updated:
12/07/2020
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Healthy Volunteers, Liver Cancer, Lung Cancer
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Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
NCT03331302
Recruiting
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/02/2020
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Chronic Obstructive Pulmonary Disease
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Spinal Cord Injury Registry - North American Clinical Trials Network
NCT00178724
Recruiting
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI). Information will be collected on the natural history of SCI and course of treatment through the first 12 months from the date of injury or long as medically indicated. Data collected includes imaging information from CT or MRI scans, neurological a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/22/2020
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Spinal Cord Injury
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Focal Salvage HDR Brachytherapy for Locally Recurrent Prostate Cancer in Patients Treated With Prior Radiotherapy
NCT03312972
Recruiting
This purpose of this study is to evaluate the safety and effectiveness of a technique called focal high-dose-rate (HDR) brachytherapy as treatment for prostate cancer that has come back in the prostate after prior radiotherapy. The study will examine the safety and efficacy of the treatment. The type of radiation that participants in this research will receive is targeted directly at the areas of the prostate where recurrent disease is evident, while avoiding treatment of the normal appearing pr... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
05/29/2020
Locations: University of Virginia School of Medicine, Charlottesville, Virginia
Conditions: Locally Recurrent Prostate Cancer
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Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML
NCT03258931
Recruiting
A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treat... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/21/2020
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Newly Diagnosed FLT3 Mutated AML
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FDG and FDOPA PET Demonstration of Functional Brain Abnormalities
NCT04315584
Recruiting
The purpose of this pilot study will be to conduct a clinical trial using a time-of-flight PET scanner and MRI scanner to test an improved method for differentiating tumor recurrence from radiation necrosis in glioblastoma patients. We will attempt to do so by performing a static and dynamic FDG-PET scan, a static and dynamic FDOPA-PET scan, and a multiparametric MRI scan - then comparing the results with surgical pathology and static FDG-PET scans. We hypothesize that the new quantitative kinet... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2020
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Glioblastoma
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Mechanistic Clinical Trial of Advanced Imaging for CRT
NCT03398369
Recruiting
This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.
Gender:
All
Ages:
Between 20 years and 90 years
Trial Updated:
02/04/2020
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Heart Failure, Systolic
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Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
NCT02803957
Recruiting
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
Gender:
All
Ages:
21 years and above
Trial Updated:
12/04/2019
Locations: Valley Health System | Virginia, Winchester, Virginia
Conditions: Mitral Valve Insufficiency
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