There are currently 69 active clinical trials seeking participants for Insomnia research studies. The states with the highest number of trials for Insomnia participants are California, Florida, Texas and Ohio.
Targeting Adolescent Insomnia to Lessen Overall Risk of Suicidal Behavior
NCT05390918
Recruiting
This study will test the effectiveness of a sleep-related primary suicide prevention program entitled TAILOR (Targeting Adolescent Insomnia to Lessen Overall Risk of Suicidal Behavior), which includes specific behavior-change strategies for adolescents at risk of suicidal behavior who suffer from difficulties falling asleep, staying asleep, and/or insufficient sleep.
Gender:
ALL
Ages:
Between 11 years and 18 years
Trial Updated:
03/18/2025
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Insomnia, Suicidal Ideation, Suicide, Attempted
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Targeting Insomnia to Improve Outcomes in Adults With Problematic Cannabis Use
NCT05814822
Recruiting
This study will compare the efficacy of telemedicine-delivered cognitive behavioral therapy for insomnia tailored for people using cannabis for sleep (CBTi-CB-TM) to telemedicine-delivered sleep hygiene education (SHE-TM) on sleep, cannabis use, and daytime functioning. We will also evaluate the effects of CBTi-CB-TM on fundamental sleep regulatory system - homeostatic sleep drive - and its association with clinical outcomes.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
08/15/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Insomnia
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A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care
NCT05759065
Recruiting
The overall objective of this study is to conduct a randomized effectiveness-implementation trial to test the non-inferiority of tele-Brief Behavioral Treatment for Insomnia vs. tele-Cognitive-Behavioral Therapy for Insomnia among socioeconomically disadvantaged adults with insomnia in the primary care setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Insomnia
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Treatments for Insomnia in Veterans With PTSD
NCT05194930
Recruiting
This randomized trial will compare a novel treatment, Acceptance of the Behavioral Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I) among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder. ABC-I combines the behavioral components of CBT-I with components of another behavioral therapy (Acceptance and Commitment Therapy) and has been shown to improve treatment adherence. The study objectives are: 1) to evaluate the benefits of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2025
Locations: VA Greater Los Angeles Healthcare System, Sepulveda, CA, Sepulveda, California
Conditions: Insomnia, PTSD
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Restorative Early Sleep Treatment After the Emergency Department
NCT07121270
Recruiting
The goal of this randomized controlled trial is to pilot the virtual delivery of cognitive behavioral therapy for insomnia (CBT-I) and nightmares (CBT-I\&N) via telehealth as an early intervention for treating posttraumatic sleep disturbance in acute trauma patients exposed to interpersonal violence. The main aims are to: 1. Test the acceptability, feasibility, and satisfaction of sleep-focused CBT delivered early after trauma 2. Evaluate the impact of sleep-focused CBT delivered early after t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: Henry Ford Hospital System, Detroit, Michigan
Conditions: Insomnia, Nightmares Associated With Trauma and Stress, Nightmares, PTSD - Post Traumatic Stress Disorder
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NiteCAPP: Web-based Interventions for Insomnia in Rural Dementia Caregivers
NCT04896775
Recruiting
The goal of this project evaluate the efficacy of NiteCAPP in improving insomnia in a rural dementia caregiver sample (n of 100 caregiver and PWD dyads). We will measure both the short term (post-treatment) and long term (6 and 12 months) effects of the intervention on CG sleep, arousal, inflammation, health, mood, burden and cognitive function, and PWD sleep.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: University of South Florida, Tampa, Florida
Conditions: Insomnia, Dementia
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Digital Cognitive Behavioral Treatment of Insomnia in Youth: An RCT Examining Feasibility, Acceptability, and Efficacy of NiteCAPP Jr
NCT07091149
Recruiting
The proposed pilot will examine feasibility, acceptability, and preliminary efficacy of a digital CBT-I tailored for school-aged children.
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
07/28/2025
Locations: University of South Florida, Tampa, Florida
Conditions: Insomnia
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Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to < 18 Years With Insomnia Disorder
NCT05423717
Recruiting
This study assesses the efficacy, safety, and pharmacokinetics of multiple-dose oral administration of daridorexant in pediatric subjects aged 10 to \< 18 years with insomnia disorder.
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
07/25/2025
Locations: Banner - University Medical Center Tucson, Tucson, Arizona +49 locations
Conditions: Insomnia
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Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes
NCT05593653
Recruiting
The aim of this study is to determine if suvorexant can help treat the severity of insomnia in midlife women who are pre-diabetic.
Gender:
FEMALE
Ages:
Between 40 years and 65 years
Trial Updated:
07/22/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Insomnia, Diabetes, Menopause
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Treating Insomnia in Mild Cognitive Impairment
NCT06687161
Recruiting
The goal of this study is to test a new way to improve sleep quality in persons living with mild cognitive impairment. The treatment combines a safe and gentle way to stimulate the brain, called transcranial magnetic stimulation, with a psychological treatment, called cognitive behavioral therapy for insomnia.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
07/21/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Mild Cognitive Impairment (MCI), Insomnia
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Sleep as a Mechanism of Change in Alcohol Use
NCT06286774
Recruiting
This project aims to evaluate improvement of insomnia as a mechanism of improvement in alcohol use outcomes.
Gender:
ALL
Ages:
Between 18 years and 49 years
Trial Updated:
07/18/2025
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Insomnia, Alcohol; Harmful Use
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Suvorexant for Treatment of AUD and PTSD
NCT06679062
Recruiting
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD). All participants will have a 7-day placebo run-in period, followed by a random assignment to receive placebo or suvorexant for an additonal 14 days. Post-randomization, participants will attempt to stop drinking for two weeks and will complete daily virtual diaries and study outco... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
07/16/2025
Locations: University of California - Los Angeles, Los Angeles, California +1 locations
Conditions: Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD), Insomnia
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