Indiana is currently home to 1248 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Indianapolis, South Bend, Fort Wayne and Evansville. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Comparing the Adaptation of Commercial Milk and A2 Milk in Lactose Maldigesters
NCT05669274
Recruiting
Cow's milk contains two types of β-casein: A1 and A2. It is evident from human clinical trials that milk with A1 protein produces more hydrogen and symptoms of lactose intolerance. A pro-inflammatory μ-opioid peptide BCM-7 is released from A1 but not from A2. Milk containing A1 β-casein produced more inflammatory markers than A2 β-casein. This is a double-blinded, randomized, controlled trial conducted to determine if there are changes in inflammatory markers following two weeks of milk feeding,... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/27/2023
Locations: Purdue University, West Lafayette, Indiana
Conditions: Lactose Intolerance
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Appreciation for Music Processed by Hearing Aids
NCT05568329
Recruiting
Normal-hearing participants aged 18-25 with and without musical training will listen to a series of short musical samples that have been recorded through hearing aids. The music will be played at a comfortable listening level. Subjects will use the computer to rate the sound quality of the music on a 7-point Likert scale.
Gender:
All
Ages:
Between 18 years and 25 years
Trial Updated:
03/27/2023
Locations: Purdue University, West Lafayette, Indiana
Conditions: Sensorineural Hearing Loss
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Blue Light Cystoscopy With Cysview® Registry
NCT02660645
Recruiting
Registry study to gather more information on the current use of Blue Light Cystoscopy with Cysview (BLCC) in urologists' practices.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Bladder Cancer
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Technology Enhanced Adolescent Mental Health (TEAM)
NCT05343039
Recruiting
Adolescent nonsuicidal self-injury (NSSI) and alcohol misuse, alone and especially in combination, portend significant functional impairment in adulthood (e.g., relationship dysfunction, depression, suicidality). Although psychosocial interventions for NSSI and substance use are effective for some, they are also expensive and require highly trained clinicians. Treatment is therefore often unavailable to disadvantaged adolescents and those who live rurally. Thus, lower-cost alternative treatments... Read More
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
03/21/2023
Locations: University of Notre Dame, South Bend, Indiana
Conditions: Nonsuicidal Self Injury, Alcohol Abuse, Vagus Nerve Stimulation
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The Happy Families Project: Testing the Effectiveness of a Conflict Resolution Program for Families
NCT04980794
Recruiting
This study is designed to test the effectiveness of a psychoeducation-based program to address communication and conflict resolution in families, thereby supporting mental health in children and their caregivers.
Gender:
All
Ages:
4 years and above
Trial Updated:
03/21/2023
Locations: Fort Wayne Center for Children and Families, Fort Wayne, Indiana
Conditions: Mental Health, Conflict
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Prospective Multi-Center Randomized Study for Evaluating the EVAHEART®2 Left Ventricular Assist System
NCT01187368
Recruiting
This is a prospective, multi-center, unblinded, randomized, controlled, and non-inferiority study comparing the EVA2 LVAS to the most recent magnetically levitated centrifugal LVAS (HM3 LVAS).
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2023
Locations: St. Vincent Hospital Indianapolis, Indianapolis, Indiana
Conditions: Heart Failure
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Ortho-R® for Rotator Cuff Repair Compared With Standard of Care Rotator Cuff Repair Without Ortho-R®
NCT05333211
Recruiting
Phase I/II, multi-center, prospective, blinded 2arm, parallel design and randomized controlled study. Assessing the Ortho-R/PRP combination and standard of care for rotator cuff repair, will be compared though 12 months.
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
03/17/2023
Locations: The Orthopaedic Research Foundation, Inc., Indianapolis, Indiana
Conditions: Rotator Cuff Tears
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Hydroxyurea Optimization Through Precision Study
NCT03789591
Recruiting
Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to standard weight-based dosing for children with SCA. The primary objective of the study is to evaluate whether a pharmacokinetics-based starting hydroxyurea dose thieves superior fetal hemoglobin response to to standard weight-based initial dosing. Patients will be recruited from the pediatric sickle cell clin... Read More
Gender:
All
Ages:
Between 6 months and 21 years
Trial Updated:
03/09/2023
Locations: Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana
Conditions: Sickle Cell Disease, Sickle Cell Anemia
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Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
NCT00169806
Recruiting
Kidney stones are very common. They affect 3-5% of the population in the United States. Many people are hospitalized for the treatment of kidney stones and some may die. Better understanding of what causes kidney stones is useful in both the treatment and prevention of kidney stones. However, exactly what causes kidney stones is unknown. The most common type of kidney stones contains calcium, which sometimes is attached to a part of the kidney important in producing the final urine, called the... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2023
Locations: IU Health North Hospital, Indianapolis, Indiana
Conditions: Nephrocalcinosis, Renal Calculi, Hypercalciuria, Hyperparathyroidism, Cystinuria
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Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow
NCT03363373
Recruiting
Children and adults diagnosed with high-risk neuroblastoma patients with primary refractory disease or incomplete response to salvage treatment in bone and/or bone marrow will be treated for up to 101 weeks with naxitamab and granulocyte-macrophage colony stimulating factor (GM-CSF). Patients will be followed for up to five years after first dose. Naxitamab, also known as hu3F8 is a humanised monoclonal antibody targeting GD2
Gender:
All
Ages:
1 year and above
Trial Updated:
03/06/2023
Locations: Riley Hospital for Children, Indianapolis, Indiana
Conditions: Neuroblastoma
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Study of Neoadjuvant Chemotherapy Plus Trastuzumab and Pertuzumab in HER2-Negative Breast Cancer Patients With Abnormal HER2 Signaling
NCT03412643
Recruiting
This is a prospective, single arm, open label, multicenter interventional study designed to evaluate the efficacy of neoadjuvant chemotherapy with anti-HER2 antibodies in patients with HER2-negative invasive breast cancer who have abnormal HER2 signaling activity determined by the Celcuity CELx HER2 Signaling Function (HSF) testing.
Gender:
Female
Ages:
18 years and above
Trial Updated:
03/03/2023
Locations: Fort Wayne Medical Oncology and Hematology, Inc., Fort Wayne, Indiana
Conditions: HER2-negative Breast Cancer
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Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
NCT01838512
Recruiting
The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/16/2023
Locations: St. Vincent Anderson Regional Hospital, Anderson, Indiana
Conditions: Multiple Myeloma
Register for Updates