Indiana is currently home to 1248 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Indianapolis, South Bend, Fort Wayne and Evansville. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of Individuals Affected With Hypoplasminogenemia
NCT03797495
Recruiting
This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved therapeutic modalities
Gender:
All
Ages:
All
Trial Updated:
06/16/2023
Locations: Indiana Hemophila @Thrombosis Center, Indianapolis, Indiana
Conditions: Plasminogen Deficiency
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Non-invasive Vagus Nerve Stimulation in the Treatment of Crohn's Disease - A Pilot Study
NCT05165108
Recruiting
To assess the safety and efficacy of transcutaneous vagal stimulation in adult patients with active Crohn's disease.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
06/06/2023
Locations: Indiana University, Indianapolis, Indiana
Conditions: Crohn Disease
Register for Updates
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
NCT04827238
Recruiting
The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.
Gender:
All
Ages:
All
Trial Updated:
06/06/2023
Locations: eCommunity, Indianapolis, Indiana
Conditions: Aortic Stenosis, Aortic Valve Stenosis
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SurvivorLink: Scalability of an Electronic Personal Health Record
NCT03543852
Recruiting
Previous research suggests that children and adolescents with cancer are at heightened risk of late effects that can occur months or years after cancer treatment, yet little is known about programs that increase their return for follow-up cancer care and late effects surveillance. This study will evaluate the impact of an electronic personal health record and education system, SurvivorLink, for pediatric cancer survivors and their caregivers. The researchers will develop a standardized intervent... Read More
Gender:
All
Ages:
All
Trial Updated:
06/06/2023
Locations: Riley Children's Health, Indianapolis, Indiana
Conditions: Childhood Cancer
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Improving Post-discharge Antimicrobial Use
NCT05471726
Recruiting
One in five hospitalized patients is prescribed an antimicrobial at the time of discharge, and a large proportion of these post-discharge antimicrobials are unnecessary. The investigators will evaluate a novel method for reviewing post-discharge antimicrobial prescriptions in real-time with the goal of improving antimicrobial selection and duration.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2023
Locations: Richard Roudebush VA Medical Center, Indianapolis, Indiana
Conditions: Infections
Register for Updates
Gastric Per-Oral Endoscopic Myotomy (G-POEM) for the Treatment of Gastroparesis
NCT04434781
Recruiting
Gastric Per-Oral Endoscopic Myotomy (G-POEM) is a procedure for the Treatment of Gastroparesis.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2023
Locations: Indiana University Hospital, Indianapolis, Indiana
Conditions: Gastroparesis
Register for Updates
Physical Therapy for Men Undergoing Prostatectomy
NCT02558946
Recruiting
The purpose of this study is to determine if pelvic floor muscle training with a physical therapist before and after surgery will improve health-related quality of life following robot-assisted radical prostatectomy.
Gender:
Male
Ages:
18 years and above
Trial Updated:
05/19/2023
Locations: IU Health Methodist Hospital and IU Health University Hospital, Indianapolis, Indiana
Conditions: Prostate Cancer, Urinary Incontinence, Pelvic Floor Physical Therapy
Register for Updates
Factors Predicting Persistence of Oncogenic HPV and Cervical Dysplasia in HIV Infected Kenyan Women
NCT04045652
Recruiting
This study will utilize a longitudinal study design to better understand the natural history of oncogenic Human Papillomavirus (HPV) infections in Human Immunodeficiency Virus (HIV)-infected and HIV-uninfected Kenyan women, including the potentially modifiable (and non-modifiable) factors that are associated with progression of oncogenic HPV infection to clinical disease, including cervical cancer.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
05/17/2023
Locations: Indiana University Melvin & Bren Simon Cancer Center, Indianapolis, Indiana
Conditions: HIV/AIDS, Cervical Dysplasia, HIV Infections
Register for Updates
Sentence Production Training in Aphasia
NCT05415501
Recruiting
This study focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which priming conditions are most effective in creating maximal learning effects. Then, in a later experiment, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the experiments.
Gender:
All
Ages:
Between 21 years and 85 years
Trial Updated:
05/16/2023
Locations: Purdue University, West Lafayette, Indiana
Conditions: Aphasia
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JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors
NCT04720976
Recruiting
To evaluate the safety and tolerability of JAB-3312 administered in investigational regimens in adult participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: Research Site, Indianapolis, Indiana
Conditions: Solid Tumor, NSCLC
Register for Updates
Academic-Community EPINET (AC-EPINET)
NCT04497857
Recruiting
The investigators propose to examine the effects of CSC services delivered via TH (CSC-TH) versus the standard clinic-based CSC model (CSC-SD) on engagement and outcomes in a 12-month, randomized trial.
Gender:
All
Ages:
Between 16 years and 35 years
Trial Updated:
05/16/2023
Locations: Prevention and Recovery Center for Early Psychosis, Indianapolis, Indiana
Conditions: Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders, Major Depression With Psychotic Features, Bipolar Disorder With Psychotic Features
Register for Updates
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
NCT04129931
Recruiting
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week washout.
Gender:
All
Ages:
12 years and above
Trial Updated:
05/16/2023
Locations: Riley Hospital for Children, Indianapolis, Indiana
Conditions: Asthma
Register for Updates