Indiana is currently home to 1247 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Indianapolis, South Bend, Fort Wayne and Evansville. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Comparing the Adaptation of Commercial Milk and A2 Milk in Lactose Maldigesters
NCT05669274
Recruiting
Cow's milk contains two types of β-casein: A1 and A2. It is evident from human clinical trials that milk with A1 protein produces more hydrogen and symptoms of lactose intolerance. A pro-inflammatory μ-opioid peptide BCM-7 is released from A1 but not from A2. Milk containing A1 β-casein produced more inflammatory markers than A2 β-casein. This is a double-blinded, randomized, controlled trial conducted to determine if there are changes in inflammatory markers following two weeks of milk feeding,... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/27/2023
Locations: Purdue University, West Lafayette, Indiana
Conditions: Lactose Intolerance
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Appreciation for Music Processed by Hearing Aids
NCT05568329
Recruiting
Normal-hearing participants aged 18-25 with and without musical training will listen to a series of short musical samples that have been recorded through hearing aids. The music will be played at a comfortable listening level. Subjects will use the computer to rate the sound quality of the music on a 7-point Likert scale.
Gender:
All
Ages:
Between 18 years and 25 years
Trial Updated:
03/27/2023
Locations: Purdue University, West Lafayette, Indiana
Conditions: Sensorineural Hearing Loss
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Blue Light Cystoscopy With Cysview® Registry
NCT02660645
Recruiting
Registry study to gather more information on the current use of Blue Light Cystoscopy with Cysview (BLCC) in urologists' practices.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Bladder Cancer
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Medications in Breast Milk: A Convenience Pharmacokinetic Study
NCT05099484
Recruiting
The benefits of breastfeeding and human milk consumption by infants has been clearly demonstrated. Benefits to the infant include reduction of infant and childhood diseases and allergies. Benefits to the woman include more rapid return to pre-pregnancy weight and reduced risk of health problems such as cardiovascular disease and diabetes in the future. Many women take medications as part of their standard of care and for multiple medical reasons in the postpartum period, when breastfeeding occur... Read More
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
03/25/2023
Locations: Indiana University, Indianapolis, Indiana
Conditions: Pregnancy Related
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Reducing Risk of Dementia Through Deprescribing
NCT04270474
Recruiting
A cluster-randomized controlled trial (RCT) called "Reducing Risk of Dementia through Deprescribing" (R2D2) to evaluate the impact of a deprescribing intervention on important cognitive and safety outcomes.
Gender:
All
Ages:
65 years and above
Trial Updated:
03/22/2023
Locations: Eskenazi Health, Indianapolis, Indiana
Conditions: Dementia, Alzheimer Disease, Late Onset
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Technology Enhanced Adolescent Mental Health (TEAM)
NCT05343039
Recruiting
Adolescent nonsuicidal self-injury (NSSI) and alcohol misuse, alone and especially in combination, portend significant functional impairment in adulthood (e.g., relationship dysfunction, depression, suicidality). Although psychosocial interventions for NSSI and substance use are effective for some, they are also expensive and require highly trained clinicians. Treatment is therefore often unavailable to disadvantaged adolescents and those who live rurally. Thus, lower-cost alternative treatments... Read More
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
03/21/2023
Locations: University of Notre Dame, South Bend, Indiana
Conditions: Nonsuicidal Self Injury, Alcohol Abuse, Vagus Nerve Stimulation
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The Happy Families Project: Testing the Effectiveness of a Conflict Resolution Program for Families
NCT04980794
Recruiting
This study is designed to test the effectiveness of a psychoeducation-based program to address communication and conflict resolution in families, thereby supporting mental health in children and their caregivers.
Gender:
All
Ages:
4 years and above
Trial Updated:
03/21/2023
Locations: Fort Wayne Center for Children and Families, Fort Wayne, Indiana
Conditions: Mental Health, Conflict
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Prospective Multi-Center Randomized Study for Evaluating the EVAHEART®2 Left Ventricular Assist System
NCT01187368
Recruiting
This is a prospective, multi-center, unblinded, randomized, controlled, and non-inferiority study comparing the EVA2 LVAS to the most recent magnetically levitated centrifugal LVAS (HM3 LVAS).
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2023
Locations: St. Vincent Hospital Indianapolis, Indianapolis, Indiana
Conditions: Heart Failure
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Ortho-R® for Rotator Cuff Repair Compared With Standard of Care Rotator Cuff Repair Without Ortho-R®
NCT05333211
Recruiting
Phase I/II, multi-center, prospective, blinded 2arm, parallel design and randomized controlled study. Assessing the Ortho-R/PRP combination and standard of care for rotator cuff repair, will be compared though 12 months.
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
03/17/2023
Locations: The Orthopaedic Research Foundation, Inc., Indianapolis, Indiana
Conditions: Rotator Cuff Tears
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Hydroxyurea Optimization Through Precision Study
NCT03789591
Recruiting
Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to standard weight-based dosing for children with SCA. The primary objective of the study is to evaluate whether a pharmacokinetics-based starting hydroxyurea dose thieves superior fetal hemoglobin response to to standard weight-based initial dosing. Patients will be recruited from the pediatric sickle cell clin... Read More
Gender:
All
Ages:
Between 6 months and 21 years
Trial Updated:
03/09/2023
Locations: Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana
Conditions: Sickle Cell Disease, Sickle Cell Anemia
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Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
NCT00169806
Recruiting
Kidney stones are very common. They affect 3-5% of the population in the United States. Many people are hospitalized for the treatment of kidney stones and some may die. Better understanding of what causes kidney stones is useful in both the treatment and prevention of kidney stones. However, exactly what causes kidney stones is unknown. The most common type of kidney stones contains calcium, which sometimes is attached to a part of the kidney important in producing the final urine, called the... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2023
Locations: IU Health North Hospital, Indianapolis, Indiana
Conditions: Nephrocalcinosis, Renal Calculi, Hypercalciuria, Hyperparathyroidism, Cystinuria
Register for Updates
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
NCT05763602
Recruiting
The purpose of this study is to see whether applying povidone iodine (PVI) to the noses of patients undergoing lower extremity (leg, ankle, or foot) orthopedic fixation procedures of high-energy lower extremity fractures (HELEF) will decrease the patients' risk of surgical site infections (SSI), particularly those caused by Staphylococcus aureus.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/06/2023
Locations: University of Indiana, Indianapolis, Indiana
Conditions: Surgical Site Infection
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