Iowa is currently home to 812 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Iowa City, Des Moines, Sioux City and Cedar Rapids. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery
NCT06199999
Recruiting
The proposed intervention will examine two alternative methods for postoperative pain control. Two treatment arms of this study will include subjects who receive an erector spinae block (ESP) after induction of anesthesia but prior to the start of surgery and subjects who will receive a high volume of local anesthetic infiltration at the end of the procedure before emergence from anesthesia. The control group of subjects will undergo spinal surgery with general anesthesia but without any regiona... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/16/2024
Locations: University of Iowa Health Care Medical Center, Iowa City, Iowa
Conditions: Postoperative Delirium, Pain, Postoperative, Degenerative Disc Disease
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Project Talk Trial: Engaging Underserved Communities in End-of-life Conversations
NCT04612738
Recruiting
Compared to the general population, individuals from underserved communities are more likely to receive low quality end-of-life care and unwanted, costly and burdensome treatments due in part to a lack of advance care planning (ACP; the process of discussing wishes for end-of-life care with loved ones/clinicians and documenting them in advance directives). This study will use existing, trusted, and respected social networks to evaluate two conversation-based tools intended to engage underserved... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2024
Locations: Trinity Lutheran Church, Cherokee, Iowa
Conditions: Advance Care Planning, Advance Directives, Terminal Illness, Chronic Illness, Communication
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Objectively Diagnose and Monitor Treatment of Light Sensitivity
NCT03694626
Recruiting
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/15/2024
Locations: University of Iowa Health Care, Iowa City, Iowa
Conditions: Photophobia, Traumatic Brain Injury, Migraine
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New Non-invasive Modalities for Assessing Retinal Structure and Function
NCT03475173
Recruiting
This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other visual function tests.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
05/15/2024
Locations: University of Iowa Department of Ophthalmology, Iowa City, Iowa
Conditions: Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion, Hemianopia, Leber Hereditary Optic Neuropathy, Acute Zonal Occult Outer Retinopathy
Register for Updates
Smartphone Flicker Fusion Test for Patients With Optic Disorders.
NCT03475147
Recruiting
The purpose of this project is to validate a quick, easy-to-use and administer smartphone flicker fusion test. The app (called eyeFusion) can potentially be used to easily and quickly collect critical flicker fusion measurements on patients admitted with optic disorders as part of the clinical care process.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/15/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Scotoma
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Empagliflozin Treatment in Kidney Transplant Recipients
NCT06013865
Recruiting
Kidney transplantation improves the health and quality of life for those Veterans with end stage kidney disease (ESKD). While early patient and graft survival are excellent, long-term outcomes continue to be challenging. Patient death with existing kidney graft function occurs in about half of all recipients over time. This is primarily due to the development of cardiovascular disease in a patient population with multiple preexisting cardiac disease risk factors. There has been little progress i... Read More
Gender:
All
Ages:
19 years and above
Trial Updated:
05/14/2024
Locations: Iowa City VA Health Care System, Iowa City, IA, Iowa City, Iowa
Conditions: Kidney Transplant, Type 2 Diabetes
Register for Updates
Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
NCT05946785
Recruiting
The purpose of this investigation is to examine the role of oxidative stress in aberrant microvascular function in otherwise healthy women with a history of GDM.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
05/14/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Gestational Diabetes, Vascular Endothelial Function
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IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
NCT04221815
Recruiting
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been shown in clinical trials, registries, and meta-analyses to reduce recurrent events after PCI. This is accomplished by improving the angiographic result with lesion and vessel assessment to guide stent selection and implantation and intravascular imaging following stent implantation to ensure an adequate treatment endpoint has been achieved. Despite extensive literature supporting the use of IVUS in PCI, util... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/14/2024
Locations: MercyOne Iowa Heart Center, Des Moines, Iowa
Conditions: Atherosclerosis
Register for Updates
Pulmonary Hypertension Association Registry
NCT04071327
Recruiting
The PHA Registry (PHAR) is a national study about people who have pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). PHAR collects information from people with PAH and CTEPH who are cared for in participating PHA-accredited Pulmonary Hypertension Care Centers throughout the U.S. PHAR will determine how people with PAH and CTEPH are evaluated, tested, and treated, and will observe how well these participants do. The goal is to see if people with PH a... Read More
Gender:
All
Ages:
0 years and above
Trial Updated:
05/14/2024
Locations: University of Iowa Hospitals & Clinic, Iowa City, Iowa
Conditions: Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Hypertension
Register for Updates
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
NCT05763602
Recruiting
The purpose of this study is to see whether applying povidone iodine (PVI) to the noses of patients undergoing lower extremity (leg, ankle, or foot) orthopedic fixation procedures of high-energy lower extremity fractures (HELEF) will decrease the patients' risk of surgical site infections (SSI), particularly those caused by Staphylococcus aureus.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Surgical Site Infection
Register for Updates
A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children
NCT05543616
Recruiting
The purpose of this clinical trial is to learn about the safety, extent of the side effects, and immune responses of the study vaccine (called variant-adapted BNT162b2 RNA-based vaccine) in healthy children. The trial is divided into 5 individual studies or substudies based on age group and prior history of COVID-19 vaccinations. All participants in each of the 5 sub-studies will receive study vaccine as a shot depending on what group they are in. Substudy A design: Phase 1 includes participant... Read More
Gender:
All
Ages:
Between 6 months and 11 years
Trial Updated:
05/13/2024
Locations: The Iowa Clinic, P.C., Ankeny, Iowa
Conditions: SARS-CoV-2 Virus, Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19
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Oxytocin and Fetal Heart Rate Changes
NCT03232918
Recruiting
The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia. The study hypothesis is that decreasing the oxytocin infusion rate by 50 % prior to initiation of combined spinal epidural analgesia will cause a reduction in the incidence of adverse fetal heart rate changes.
Gender:
Female
Ages:
Between 18 years and 55 years
Trial Updated:
05/13/2024
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Fetal Bradycardia Complicating Labor and Delivery, Fetal Bradycardia During Labor, Fetal Heart Rate or Rhythm Abnormality Affecting Fetus
Register for Updates