Iowa is currently home to 798 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Iowa City, Des Moines, Sioux City and West Des Moines. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Behavioral Economic & Staffing Strategies in the ICU
NCT06184945
Recruiting
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill adults with known health disparities. Investigators will specifically evaluate two discrete strategies grounded in behavioral economic and implementation science theory (i.e., real-time audit and feedback and registered nurse implementation facilitation) to increase adopt... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
09/30/2024
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication, ICU Acquired Weakness, Pain
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Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial
NCT04095663
Recruiting
The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. A parallel observational cohort will include those who are disinclined to have their treatment choice randomized, but are willing to contribute information about their outcomes. The goal of the COSMID trial is to answer the question:... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2024
Locations: University of Iowa Healthcare, Iowa City, Iowa
Conditions: Diverticulitis
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Consent for Use of Stored Patient Specimens for Future Testing
NCT00031408
Recruiting
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing.
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2024
Locations: Department of Internal Medicine, University of Iowa Hospitals & Clinics CRS (1504), Iowa City, Iowa
Conditions: HIV Infections
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Treatment Targets in Spanish and English Bilingual Speech Intervention
NCT06416306
Recruiting
The goal of this clinical trial is to learn which speech treatment targets result in the greatest amount of speech learning in Spanish-English bilingual children with speech sound disorders. The main questions it aims to answer are: * Does linguistic complexity of the treatment target increase the amount of generalized learning within the treated language? * Does linguistic complexity of the treatment target increase the amount of generalized speech across languages? Researchers will compare i... Read More
Gender:
ALL
Ages:
Between 4 years and 7 years
Trial Updated:
09/12/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Speech Sound Disorder
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Single-Sided Deafness and Asymmetric Hearing Loss
NCT04506853
Recruiting
The purpose of the study is to evaluate the long-term safety and effectiveness of cochlear implantation of the approved population in adults and children with single-sided deafness and asymmetric hearing loss.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
09/12/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Hearing Loss, Unilateral, Hearing Loss, Sensorineural
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Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation
NCT06499844
Recruiting
The increase in skin blood flow in response to rapid local heating of the skin (i.e., cutaneous vasodilation) is commonly used to assess nitric oxide (NO)-dependent dilation and overall microvascular function. Historically, rapid local heating to 42°C was considered the standard approach for these assessments. More recently, many investigators have adopted rapid local to 39°C instead, based on its larger dependency on NO and therefore improved ability to quantify NO-dependent dilation without th... Read More
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
09/11/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Endothelial Function
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Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia
NCT05937841
Recruiting
Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs is unclear but may be related to impaired endothelial function and dysregulation of the angiotensin system that occurs during the preeclamptic pregnancy and persists postpartum, despite the remission of clinical symptoms. The purpose of this investigation is to determine the mechanisms contributing to this lasti... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
09/11/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Preeclampsia Postpartum
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Encore PFO Closure Device - The PerFOrm Trial
NCT05537753
Recruiting
The objective of this study is to establish reasonable assurance of safety, effectiveness, and noninferiority of the Encore PFO closure device when compared to any investigator chosen FDA-approved PFO closure device.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
09/11/2024
Locations: Mercy One Iowa Heart Center, West Des Moines, Iowa
Conditions: Patent Foramen Ovale, Cryptogenic Stroke
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Breast Cancer PSMA PET
NCT06586047
Recruiting
The purpose of this research is to determine the expression of Prostate Specific Membrane Antigen(PSMA) in metastatic Triple Negative Breast Cancer (TNBC) patients using Fludeoxyglucose F18 (FDG) PET/CT as the gold standard. The investigators hypothesize that most lesions in metastatic TNBC are PSMA-avid; and thus PSMA-based radionuclide therapy can be a valid treatment option for TNBC, and clinical trials can be designed for this purpose. Thirty metastatic TNBC patients will be enrolled and wil... Read More
Gender:
FEMALE
Ages:
Between 18 years and 90 years
Trial Updated:
09/03/2024
Locations: University of Iowa Healthcare, Iowa City, Iowa
Conditions: Triple Negative Breast Cancer
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From Opinion to Evidence: Multi-site Evaluation of Custom Dynamic Orthosis Best Practices
NCT06352788
Recruiting
This study is designed to support evidence-based practice and optimal care by evaluating how different configurations of two types of carbon fiber custom dynamic orthoses (CDOs) influences outcomes following traumatic lower extremity injury.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/26/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Foot Injury
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The Effects of Heel Distraction Height on Foot Loading With Carbon Fiber Custom Dynamic Orthoses
NCT06127316
Recruiting
Carbon fiber custom dynamic orthoses (CDOs) and unloading ankle foot orthoses (AFOs) have shown varying levels of success in reducing forces acting on different regions of the bottom of the foot during gait. CDOs and unloading AFOs have shown differing offloading capabilities across different regions of the foots (hindfoot, midfoot, forefoot) which may be related to a distinct difference between CDOs and unloading AFOs: CDOs do not suspend, or distract, the foot away from the footplate. The purp... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/26/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Traumatic Lower Limb Injury
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
NCT05548283
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
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