Iowa is currently home to 819 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Iowa City, Des Moines, Sioux City and Cedar Rapids. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Genetic Epidemiology of Rotator Cuff Tears: The cuffGEN Study
Recruiting
Rotator cuff tear is one of the most common reasons to seek musculoskeletal care, and cuff repair is one of the fastest growing ambulatory surgery procedures. However, the etiology of cuff tears, reasons for variability treatment success, and causes of FI are poorly understood. A large-scale genome-wide association studies (GWAS) using imaging-verified rotator cuff tear cases and controls can address limitations in rigor of prior research and assess the genetic basis of FI and functional outcome... Read More
Gender:
All
Ages:
Between 40 years and 85 years
Trial Updated:
04/25/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Rotator Cuff Tears
Prenatal Aspirin and Postpartum Vascular Function
Recruiting
Preeclampsia is a pregnancy disorder affecting ~5-10% of pregnancies in the United States. Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs is unclear but may be related to blood vessel damage and increased inflammation that occurs during the preeclamptic pregnancy and persists postpartum. Low dose aspirin (LDA; 75-150mg/daily) is currently the most effective... Read More
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
04/24/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Preeclampsia, Microvascular Function
Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection
Recruiting
Surgical site infections (SSIs) are associated with increased patient morbidity, mortality, and healthcare costs. ESKAPE (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) pathogens are particularly pathogenic because they have increased capacity to acquire resistance and virulence traits. The investigators have proven that a multifaceted program involving improved basic perioperative preventive measures can generate substantial reductions in S. aureus trans... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/21/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Infection
MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study
Recruiting
The objective of this study is to generate contemporaneous clinical data to facilitate a reasonable comparison of the performance of the FRED™ X™ device with the performance of the FRED™ device. The data generated from this study will be compared to the safety and effectiveness of the FRED™ device by meeting the same performance goals (PGs) established for the FRED™ pivotal study.
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
04/20/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Intracranial Aneurysm
A Study of DF6002 Alone and in Combination With Nivolumab
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug-levels, drug-effects and preliminary anti-tumor activity of DF6002 alone and in combination with Nivolumab in participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Solid Tumors
Quality of Pediatric Resuscitation in a Multicenter Collaborative
Recruiting
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Gender:
All
Ages:
Between 0 years and 17 years
Trial Updated:
04/19/2023
Locations: University of Iowa Stead Family Children's Hospital, Iowa City, Iowa
Conditions: Cardiac Arrest, Cardiopulmonary Arrest
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. Until recently, the mainstay of treatment for these patients was supportive medical care. Howe... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Spinal Muscular Atrophy (SMA)
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
Recruiting
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
Gender:
All
Ages:
30 years and below
Trial Updated:
04/11/2023
Locations: Blank Children's Hospital, Des Moines, Iowa
Conditions: Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Regional Neuroblastoma, Stage 4 Neuroblastoma, Stage 4S Neuroblastoma
Optimizing and Standardizing 129Xe Gas Exchange MRI to Visualize Regional Therapy Response in Interstitial Lung Disease
Recruiting
The purpose of this multi-centered, NIH-sponsored study is to to develop an optimal protocol for using noninvasive 129Xe gas exchange MRI to detect changing disease activity in interstitial lung diseases (ILDs).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/10/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Interstitial Lung Diseases
BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma
Recruiting
The study will assess the safety and efficacy of BXQ-350 plus modified FOLFOX7 (mFOLFOX7) and bevacizumab in participants who have newly diagnosed metastatic adenocarcinoma of the colon/rectum. The study will also evaluate if the administration of BXQ-350 with mFOLFOX7 and bevacizumab may diminish oxaliplatin induced sensory neurotoxicity, enabling participants to receive the total and planned doses of mFOLFOX7. All participants will receive BXQ-350 by intravenous (IV) infusion along with stand... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/05/2023
Locations: The University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Metastatic Colorectal Carcinoma, Neuropathy
Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode
Recruiting
The ECLIPSE (Evaluation of the ctDNA LUNAR test in an Average Patient Screening Episode) study is a prospective, observational multi-site study without randomization. The primary objective of the study is to evaluate the performance characteristics of a blood-based ctDNA LUNAR-2 test to detect colorectal cancer in a screen-relevant, average risk population.
Gender:
All
Ages:
Between 45 years and 84 years
Trial Updated:
04/04/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Colorectal Cancer
Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression
Recruiting
This clinical study is evaluating a drug called BT7480 alone and in combination with nivolumab in participants with advanced solid tumors associated with Nectin-4 expression. The main goals of the study are to: Find the recommended dose of BT7480 that can be given safely to participants alone and in combination with nivolumab Learn about the side effects and effectiveness of BT7480 alone and in combination with nivolumab Learn about the effect BT7480 has on the body and how BT7480 is cleared b... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/30/2023
Locations: State University of Iowa, Iowa City, Iowa
Conditions: Advanced Solid Tumor