Kansas is currently home to 952 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Wichita, Kansas City, Overland Park and Topeka. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MR-Guided Focused Ultrasound in the Treatment of Focal Epilepsy (EP001)
NCT02804230
Recruiting
The purpose of this study is to evaluate the feasibility, safety, and initial effectiveness of Exablate thermal ablation of a focal epileptic target area in the brain of patients suffering from medication-refractory epilepsy, using the Exablate transcranial system to produce multiple sonications targeted in the focus of interest. The investigators will establish the feasibility and collect data to establish the basic safety of this type of treatment as the basis for later studies that will evalu... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
09/07/2022
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Epilepsy
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Developing Hyperpolarized 129Xe MRI Biomarkers for Evaluation of Pulmonary Arterial Hypertension
NCT05339386
Recruiting
In this study, hyperpolarized 129Xe MRI will be used to evaluate treatment efficacy in patients with pulmonary arterial hypertension (PAH). Participants will be imaged at 4 timepoints (baseline, 6 weeks post-therapy initiation, 12 weeks, and 18 weeks). Images will be analyzed to develop new biomarkers and to understand treatment effects.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/06/2022
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Pulmonary Arterial Hypertension
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An Exploratory, Open-Label, Oligo-Center Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Intravenous DNV3837 in Subjects With Clostridium Difficile Infection
NCT03988855
Recruiting
This is an open-label study to evaluate the safety, efficacy, and PK of DNV3837 at a dose of 1.5 mg/kg actual body weight(BW)/day administered via IV infusion in subjects with CDI. The study will be conducted in 2 subsequent parts. In Part 1 of the study, 10 subjects of either sex with severe or non-severe CDI will be enrolled to receive DNV3837. In Part 2 of the study, up to 30 subjects with severe or non-severe CDI will be enrolled to receive DNV3837. In both parts of the study, treatment i... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/06/2022
Locations: Infectious Disease Consultants (IDC) Clinical Research, Wichita, Kansas
Conditions: Clostridium Difficile (C. Difficile)
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Quantitative Pulmonary Imaging Registry & Biorepository
NCT05530408
Recruiting
The goal of this project is to establish a registry and biorepository of images and biological samples from subjects undergoing novel pulmonary imaging methods to be used for future research aimed toward identifying clinical applications of imaging methods and toward understanding the physiological significance of imaging biomarkers. This registry and biorepository will accelerate the development of these imaging techniques and may lead toward future clinical adoption of quantitative pulmonary i... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/02/2022
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Pulmonary Disease
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Hyperpolarized 129Xe MRI of Survivors of COVID-19
NCT04659707
Recruiting
The purpose of this study is to evaluate pulmonary function of patients recovering from mild, moderate, and severe COVID-19 disease using hyperpolarized 129Xe MRI.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/29/2022
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Covid19
Register for Updates
HIFT for People With Mobility-Related Disabilities
NCT05516030
Recruiting
Investigators will examine the feasibility and health outcomes following a high-intensity functional training intervention for people with mobility-related disabilities. In addition to participant recruitment, attritions rates, and satisfaction, investigators will assess changes to both physical health outcomes (e.g., strength, body composition) and psychosocial outcomes (e.g., quality of life). The findings will provide evidence for the efficacy of HIFT to improve various health outcomes for a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/22/2022
Locations: University of Kansas, Lawrence, Kansas
Conditions: Mobility Limitation, Physical Disability
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Safety and Immunogenicity of an Intranasal RSV Vaccine Expressing SARS-CoV-2 Spike Protein (COVID-19 Vaccine) in Adults
NCT04798001
Recruiting
This study evaluates an investigational vaccine that is designed to protect humans against infection with SARS-CoV-2, the novel coronavirus causing COVID-19 disease. The investigational vaccine, MV-014-212, is a live attenuated vaccine against respiratory syncytial virus (RSV) that is expressing the spike (S) protein of SARS-CoV-2. MV-014-212 is administered as drops or a spray in the nose. Specifically, this study analyzes the safety of, and the immune response to, the vaccine when administered... Read More
Gender:
All
Ages:
Between 18 years and 69 years
Trial Updated:
08/01/2022
Locations: Johnson County Clin-Trials, Lenexa, Kansas
Conditions: Covid19
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Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple Myeloma
NCT04091126
Recruiting
This study will evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of belantamab mafodotin in combination with Velcade (bortezomib), Revlimid (lenalidomide), dexamethasone (VRd) and will determine recommended phase 3 dose (RP3D) in adult participants with newly diagnosed multiple myeloma (NDMM). Participants will receive the combination of bortezomib, lenalidomide and dexamethasone (VRd) on a 3-week cycle until cycle 8, followed by the combination of lenalidomide and d... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/22/2022
Locations: GSK Investigational Site, Westwood, Kansas
Conditions: Multiple Myeloma
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Home Air Quality Impact for Adults With Asthma
NCT05224076
Recruiting
The purposes of this study are to determine the practicality of using home indoor air quality monitoring and a smartphone app to identify home air quality changes and how these changes affect adults with asthma.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/08/2022
Locations: Barbara J Polivka, Kansas City, Kansas
Conditions: Asthma, Environmental Exposure, Home Environment Related Disease
Register for Updates
Mitigating the Pro-inflammatory Phenotype of Obesity
NCT04934228
Recruiting
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6). Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of SNA blockade (oral clonidine) compared with a BP-lowering control condition (diuretic, hydrochlorothiazide) or a placebo.
Gender:
All
Ages:
Between 18 years and 79 years
Trial Updated:
06/15/2022
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Blood Pressure, Diabetes, Obesity, Insulin Resistance, Diuretics Drug Reactions, Sympathetic Nerve Activity
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Exploring Predictors of Response to a Peer-Mediated Intervention for Preschoolers With ASD
NCT05277103
Recruiting
This study will examine what child variables (i.e., social attention and peer interest) predict communication gains in response to a peer-mediated intervention for 40 minimally-verbal preschool children with ASD and 80 peers. The Stay-Play-Talk with iPad intervention will be implemented for 8 weeks. Gains in communication and reciprocity with peers will be measured at post-treatment and in non-treatment settings. Another goal is to determine if variance in communication gains accounted for by th... Read More
Gender:
All
Ages:
Between 3 years and 6 years
Trial Updated:
05/26/2022
Locations: University of Kansas, Kansas City, Kansas
Conditions: Autism Spectrum Disorder, Nonverbal Communication
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MRI for Screening and Monitoring Scleroderma ILD
NCT05204355
Recruiting
The purpose of this study is to test MRI methods for evaluating patients with Scleroderma-associated interstitial lung disease.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/19/2022
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Scleroderma
Register for Updates