Michigan is currently home to 2183 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Ann Arbor, Detroit, Grand Rapids and Kalamazoo. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
Recruiting
The purpose of this study is to evaluate the safety and efficacy of EPX-100 as adjunctive therapy in participants with Dravet syndrome.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
08/02/2024
Locations: University of Michigan- Mott Children's Hospital, Ann Arbor, Michigan
Conditions: Dravet Syndrome
Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.
Gender:
ALL
Ages:
31 years and below
Trial Updated:
08/02/2024
Locations: Helen DeVos Children's Hospital, Grand Rapids, Michigan
Conditions: Neuroblastoma
Diabetic Foot Ulcers Microbiome and Pathogen Identification
Recruiting
This research is being done because people with diabetes have reduced healing capacity and prone to develop infections of foot wounds. This can be problematic because wounds that become infected may result in amputation and more severe complications. New evidence suggests that a better understanding of the microbiome of wounds (e.g., bacterial presence) may provide information about wound healing and provide an earlier opportunity to identify an individual who may be prone to develop diabetic fo... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/01/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Foot Ulcer, Diabetes Mellitus, Wound
A Study of CPI-0209 in Patients With Advanced Solid Tumors and Lymphomas
Recruiting
First-in-human, open-label, sequential dose escalation and expansion study of CPI-0209 in patients with advanced solid tumors and lymphomas. CPI-0209 is a small molecule inhibitor of EZH2.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2024
Locations: University of Michigan Hospital, Ann Arbor, Michigan
Conditions: Advanced Solid Tumor, Diffuse Large B Cell Lymphoma, Lymphoma, T-Cell, Mesothelioma, Malignant, Prostatic Neoplasms, Castration-Resistant, Endometrial Cancer, Ovarian Clear Cell Carcinoma
Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars
Recruiting
The purpose of this randomized, controlled clinical study is to evaluate if application of 38% SDF increases the efficacy of local anesthesia during operative dentistry on permanent molars affected by molar-incisor hypoplasia (MIH). The goal is to determine if pre-operative application of SDF results in improved local anesthesia and decrease in procedural pain in MIH affected teeth, thereby addressing an important challenge in routine clinical practice and contributing to the development of a tr... Read More
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
07/31/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Molar Incisor Hypomineralization, Anesthesia, Local
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
Recruiting
This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse - Seizure Therapy (RUL LAP-ST) treatment has more magnitude and rate of remission of SI as conventional pulse amplitude Right Unilateral Electroconvulsive Therapy (RUL ECT) (based on our prior secondary analysis). Our central hypothesis is that RUL LAP-ST has significantly... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
07/30/2024
Locations: Pine Rest Christian Mental Health Services, Grand Rapids, Michigan
Conditions: Suicidal Ideation, Major Depressive Disorder, Schizo Affective Disorder, Bipolar Disorder
Using Consumer-grade Wearable Devices for Fall Risk Evaluation and Alerts
Recruiting
Creation and use of a smartphone application for older adults to assess the participants' risk of fall. Phase 1: Compare the accuracy and validity of accelerometer and gyroscopic data from a smartphone and gold-standard, wearable sensors gathered during balance and gait activities. Phase 2: Develop a model that integrates wearable sensor data and individual characteristics, such as age, medical conditions, exercises, previous falls, fear of falls, along with gait and balance outcome measurements... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
07/29/2024
Locations: University of Michigan-Flint, Flint, Michigan
Conditions: Mass Screening
Observational Study of THC Concentrations in Acute Cannabinoid Intoxication
Recruiting
This observational study is being conducted to determine plasma concentrations of tetrahydrocannabinol (THC) and its metabolites, 11-OH-THC and THC-COOH, in plasma of subjects who visit the emergency department due to acute cannabinoid intoxication.
Gender:
ALL
Ages:
All
Trial Updated:
07/29/2024
Locations: Henry Ford Hospital, Detroit, Michigan
Conditions: Acute Cannabinoid Intoxication
Assessment of the Utility of the Pantheris Small Vessel (SV) System
Recruiting
A single-arm study to assess the utility of the Pantheris SV catheter in addressing peripheral artery disease in arteries located below the knee. Data will be collected on the percent stenosis pre- and post-atherectomy and then symptoms and adverse events noted at 30 days, 6 months, and 1 year after the procedure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2024
Locations: Advanced Cardiac and Vascular Centers, Grand Rapids, Michigan
Conditions: Peripheral Arterial Disease
Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth
Recruiting
The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area. Results from the study will inform future substance use prevention efforts targeted at youth exposed to adverse childhood experiences. Findings will also refine future models of intervention delivery in traditionally underserved communities. The main aims of the project are are... Read More
Gender:
ALL
Ages:
11 years and above
Trial Updated:
07/26/2024
Locations: Freedom Schools Collaborative, Flint, Michigan
Conditions: Behavior, Health
FT522 With Rituximab in Relapsed/Refractory B-Cell Lymphoma (FT522-101)
Recruiting
This is a phase 1 study of FT522 administered with rituximab in participants with relapsed/refractory B-cell lymphoma (R/R BCL). The primary objectives of the study are to evaluate the safety and tolerability of FT522 in combination with rituximab, and to determine the recommended phase 2 dose (RP2D) of FT522 in combination with rituximab; each objective will be assessed with or without conditioning chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2024
Locations: Karmanos Cancer Center, Detroit, Michigan
Conditions: Relapsed/Refractory B-Cell Lymphoma
ABTECT-2 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -2
Recruiting
This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinical remission in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhibitors, anti-integrin... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
07/25/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Ulcerative Colitis