Michigan is currently home to 2248 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Ann Arbor, Detroit, Grand Rapids and Kalamazoo. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Efficacy of Local Anesthetic Through Continuous Infusion
Recruiting
Efficacy of using continuous infusion of local anesthetic for post operative pain control following laparotomy.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2022
Locations: Ascension Genesys Hospital, Grand Blanc, Michigan
Conditions: Pain Control
PEN-866 in Patients With Advanced Solid Malignancies
Recruiting
Protocol PEN-866-001 is an open-label, multi-center, first-in-human Phase 1/2a study evaluating PEN-866 in patients with advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/16/2022
Locations: Henry Ford, Detroit, Michigan
Conditions: Carcinoma, Endometrial Adenocarcinoma, Neoplasms, Squamous Cell Carcinoma of the Anus, Adenocarcinoma of the Pancreas, Advanced Cancer, Solid Tumor, Solid Carcinoma, Squamous Cell Carcinoma of the Cervix, Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Vulva, Squamous Cell Carcinoma of the Penis, Gastric Cancer, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Small-cell Lung Cancer, Small Cell Lung Carcinoma, Pancreatic Ductal Adenocarcinoma, Pancreatic Adenocarcinoma
FastThread Interference Screws
Recruiting
Surgery using the Arthrex PEEK or Biocomposite FastThread Interference Screw for ACL or PCL (PCL at US sites only, Biocomposite screw PCL only) repair or reconstruction.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/15/2022
Locations: Anderson Sports Medicine, Bingham Farms, Michigan
Conditions: ACL Injury
Apple Hearing Study
Recruiting
The Apple Hearing Study is a partnership between the University of Michigan and Apple to study sound exposure and its impact on hearing health. This groundbreaking study will advance the understanding of how hearing could be impacted over time by exposure to sound at certain levels. The investigators will measure headphone and environmental sound exposures over time among participants, and determine how these exposures impact hearing and stress levels. US residents who own an iPhone, download th... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/14/2022
Locations: University of Michigan School of Public Health, Ann Arbor, Michigan
Conditions: Hearing Loss, Noise-Induced, Hearing Loss
NA-831, Atazanavir and Dexamethasone Combination Therapy for the Treatment of COVID-19 Infection
Recruiting
This Phase 2/3 trial evaluates four treatment strategies for non-critically ill hospitalized participants (not requiring ICU admission and/or mechanical ventilation) with SARS CoV-2 infection, in which participants will receive NA-831 or Atazanavir with or without Dexamethasone.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/31/2022
Locations: Coronavirus Research Institute-Testing Site, Ann Arbor, Michigan
Conditions: Coronavirus Infection, Severe Acute Respiratory Infection, Severe Acute Respiratory Syndrome Coronavirus 2
Safety and Durability of Sirolimus for Treatment of LAM
Recruiting
The MIDAS study aims to follow LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung cysts.
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/11/2022
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Lymphangioleiomyomatosis
Prophylactic Application of an Incisional Wound Vac to Prevent Wound Complications in Obese Spine Surgery Patients
Recruiting
This is a prospective randomized study evaluating the use of a prophylactic incision wound vac dressing, applied in the OR, on patients undergoing posterior spine surgery with a BMI>35. Patients are randomized in the operating room to normal postoperative dressing vs. vac dressing. The vac dressing would be left on for 72 hours postoperatively. In the interim, the patients' postoperative care can proceed as usual. Our primary outcomes will be antibiotics or return trip needed to the operating ro... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2022
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Spine Surgery, Wounds Vac
Longitudinal Performance of Epi proColon
Recruiting
This study will evaluate longitudinal performance of Epi proColon with respect to test positivity, longitudinal adherence to Epi proColon screening, adherence to follow-up colonoscopy and diagnostic yield, as well as assay failure rates.
Gender:
All
Ages:
Between 50 years and 74 years
Trial Updated:
10/29/2021
Locations: Beaumont Health System, Royal Oak, Michigan
Conditions: Colorectal Cancer, Colorectal Neoplasms
Are Adductor Canal Blocks With Bupivacaine and Added Magnesium Better at Managing Post-operative Pain Than Bupivacaine and Added Buprenorphine in Patients Undergoing Same-day Discharge Total Knee Arthroplasty?
Recruiting
The purpose of this study is to compare the use of magnesium and bupivacaine to buprenorphine and bupivacaine in post-operative adductor canal blocks (ACB); the study will determine if one combination can result in decreased opioid consumption and improved pain management for patients after same-day discharge total knee arthroplasty (TKA) . The investigators will assess whether the addition of magnesium to bupivacaine will decrease visual analog scale (VAS) pain scores, decrease post-operative... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
10/22/2021
Locations: St. Joseph Mercy Oakland Hospital, Pontiac, Michigan
Conditions: Post-operative Pain, Acute, Opioid Use
Serratus Anterior Plane Block With and Without Adjuvants in Video-assisted Thoracoscopy
Recruiting
The purpose of this study is to determine whether the addition of the serratus anterior plane block (SAPB) alone (30 mL of 0.25% bupivacaine) or plus Magnesium (150 mg of magnesium sulfate) or plus Magnesium + Buprenorphine (300 mcg) as adjuvants can improve post-operative pain in patients undergoing video-assisted thoracoscopic surgery.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
10/12/2021
Locations: St. Joseph Mercy Oakland Hospital, Pontiac, Michigan
Conditions: Post Operative Pain, Acute
Effect of Early Administration of TXA in Adult Hip Fractures
Recruiting
This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center. It is well established in the orthopedic literature that tranexamic acid (TXA) decreases blood loss and need for postoperative blood transfusion in hip fracture patients as well as total joint arthroplasty patients. A typical dosing pattern, and the dosing pattern employed at our institution, is 1 gram IV infused prior to i... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/14/2021
Locations: Ascension Genesys Hospital, Grand Blanc, Michigan
Conditions: Postoperative Blood Loss
Adaptive Phase II Study to Evaluate the Safety & Efficacy of NaBen®
Recruiting
The purpose of this study is to determine if NaBen® is a safe and effective add-on treatment for schizophrenia in adolescents.
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
09/10/2021
Locations: Michigan Clinical Research Institute, Ann Arbor, Michigan
Conditions: Schizophrenia