Minnesota is currently home to 2065 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children
NCT04783857
Recruiting
The investigators aim to address the following specific aims: * Determine the efficacy of Prog in preventing postpartum smoking relapse and reducing smoking relapse risk factors. * Examine the effects of this maternal smoking intervention on infant health. * Examine racial and ethnic differences in intervention outcomes.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
01/20/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Smoking, Smoking Cessation, Smoking Reduction
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Testicular Tissue Cryopreservation in Children
NCT02872532
Recruiting
This protocol is being designed to offer testicular tissue cryopreservation to male pediatric patients (0-17 years of age) with fertility threatening medical diagnoses or facing surgery, chemotherapy or radiation therapy that may cause loss of reproductive potential.
Gender:
MALE
Ages:
Between 0 years and 17 years
Trial Updated:
01/19/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cancer, Cancer-Related Condition, Infertility
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Safety and Effectiveness of the Luna System in People with Type 1 Diabetes Mellitus
NCT06627517
Recruiting
The purpose of this research is to evaluate the effect of a wearable insulin pump on blood sugar levels during sleep. The study device works with continuous glucose monitors (CGM) to calculate and deliver rapid-acting insulin doses during sleep. The study device does not replace long-acting, correction, or mealtime insulin. The study will involve applying the study device before bed for a period of 13 weeks. The overall study length is approximately 17 weeks. The study aims to evaluate whether... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2025
Locations: International Diabetes Center, Minneapolis, Minnesota
Conditions: Type 1 Diabetes Mellitus, Sleep Quality
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Mechanisms of Anabolic Resistance in Older Humans
NCT06617195
Recruiting
The purpose of this research is to understand how chronic inflammation affects muscle function and responses to exercise in older adults.
Gender:
ALL
Ages:
Between 21 years and 85 years
Trial Updated:
01/17/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Aging
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Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders
NCT06333652
Recruiting
The researchers are testing a medication named ravulizumab for the treatment of severe preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelets (HELLP) syndrome.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
01/17/2025
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Preeclampsia
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Liquid Biopsy in Ewing Sarcoma and Osteosarcoma As a Prognostic and Response Diagnostic: LEOPARD
NCT06068075
Recruiting
This is a prospective multicenter biomarker study evaluating the prognostic impact of ctDNA detection at diagnosis in patients with Ewing sarcoma or osteosarcoma.
Gender:
ALL
Ages:
Between 12 months and 50 years
Trial Updated:
01/17/2025
Locations: Children's Hospital's and Clinics of Minnesota, Minneapolis, Minnesota
Conditions: Ewing Sarcoma, Ewing Sarcoma of Bone, Ewing Sarcoma of Soft Tissue, Peripheral Primitive Neuroectodermal Tumor, Peripheral Primitive Neuroectodermal Tumor of Bone, Peripheral Primitive Neuroectodermal Tumor of Soft Tissue, High-grade Osteosarcoma
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A Study to Investigate Behavioral and Other Co-Occurring Outcomes With Epidiolex as Add-On Therapy in Participants Aged 1 to 65 Years of Age With Tuberous Sclerosis Complex
NCT05864846
Recruiting
The purpose of this study is to investigate behavioral and other co-occurring outcomes with EPID(I/Y)OLEX as an add-on therapy in participants aged 1 to 65 years with tuberous sclerosis complex (TSC) who experience seizures.
Gender:
ALL
Ages:
Between 1 year and 65 years
Trial Updated:
01/17/2025
Locations: Minnesota Epilepsy Group, Roseville, Minnesota
Conditions: Tuberous Sclerosis Complex Associated Neuropsychiatric Disease
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Adult Spinal Deformity Surgery Real-World Functional Activity
NCT05611775
Recruiting
The purpose of this study is to measure functional activity and stability in spinal deformity patients utilizing motion analysis testing and accelerometers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2025
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Degenerative Thoracolumbar Deformity
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GammaTile and Stupp in Newly Diagnosed GBM
NCT05342883
Recruiting
In summary, standard of care postoperative chemoradiation for patients with newly diagnosed GBM does not routinely provide durable local control or prolonged overall survival. As discussed above it seems unlikely that patient outcomes will be significantly improved with radiation dose escalation given at the time of the EBRT boost. However, as most failures are local, improving LC could potentially improve the OS of patients. To do this, we propose a shift in the traditional radiation paradigm.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Glioblastoma
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A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)
NCT04779320
Recruiting
Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe Crohn's disease will be treated with vedolizumab. The main aim of the study is to check if participants achieve remission after treatment with the vedolizumab. Remission means symptoms improve or disappear and an endoscopy shows no signs of inflammation. Participants will receive 3 infusions of vedolizumab over 6 weeks. Then, those who have... Read More
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
01/17/2025
Locations: MNGI Digestive Health, PA, Minneapolis, Minnesota
Conditions: Crohn's Disease (CD)
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RMT in Combination With Durvalumab + Chemo in Untreated Adenocarcinoma NSCLC. A Randomized Double Blind Phase II Trial
NCT04105270
Recruiting
This is a randomized, active-controlled, parallel-group, double-blind Phase II trial, of oral restorative microbiota therapy (RMT) or placebo combined with intravenous (IV) durvalumab (MEDI4736) plus chemotherapy in patients with treatment naïve advanced or metastatic adenocarcinoma non-small cell lung cancer (NSCLC)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2025
Locations: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
Conditions: Adenocarcinoma of Lung, Lung Cancer
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Sevoflurane/Dexmedetomidine Vs. Isoflurane for Pediatric Emergence Delirium
NCT06624592
Recruiting
The purpose of this study is to measure the incidences of pediatric emergence delirium between the group receiving Isoflurane and the group receiving Sevoflurane plus intravenous push dexmedetomidine.
Gender:
ALL
Ages:
Between 2 years and 7 years
Trial Updated:
01/16/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Delirium on Emergence
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