Minnesota is currently home to 2107 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Family, Responsibility, Education, Support, and Health for Food Responsiveness
NCT06207110
Recruiting
The objective of this proposed study is to compare Regulation of Cues (ROC), Family-Based Treatment (FBT), ROC+ nutrition education and reducing energy intake (ROC+) and a health education comparator (HE) for children with overweight or obesity who are high on food responsiveness (FR).
Gender:
ALL
Ages:
Between 7 years and 12 years
Trial Updated:
05/06/2025
Locations: Ambulatory Research Center - University of Minnesota, Minneapolis, Minnesota
Conditions: Obesity, Childhood
Register for Updates
Safety and Efficacy of TSHA-102 in Pediatric Females With Rett Syndrome (REVEAL Pediatric Study)
NCT06152237
Recruiting
The REVEAL Pediatric Study is a multi-center, Phase 1/2 open-label, dose-escalation and dose-expansion study of TSHA-102, an investigational gene therapy, in pediatric females with Rett Syndrome. The safety, tolerability, and preliminary efficacy of two dose levels will be evaluated. The study duration is up to 6 years.
Gender:
FEMALE
Ages:
Between 5 years and 8 years
Trial Updated:
05/06/2025
Locations: Gillette Children's Specialty Healthcare, St. Paul, Minnesota
Conditions: Rett Syndrome
Register for Updates
An Observational Research Study to Uncover Subtypes of Cancer Cachexia
NCT06073431
Recruiting
This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable). Patients with these cancer types are at risk for developing cancer cachexia (CC), which is defined as weight loss, muscle loss, and fat loss due to cancer. CC has been associated with reduced physical performance, impaired quality of life, and poorer survival. Many... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Minnesota Oncology - Burnsville, Burnsville, Minnesota
Conditions: Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Advanced Pancreatic Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Unresectable Colorectal Carcinoma, Unresectable Lung Non-Small Cell Carcinoma, Unresectable Pancreatic Adenocarcinoma
Register for Updates
Evaluation of Gender-Affirming Treatments on Pulmonary Function in Transgender and Gender Diverse Patients
NCT05587751
Recruiting
The purpose of this research study is to evaluate whether undergoing gender affirming care will impact the way the lungs function.
Gender:
ALL
Ages:
14 years and above
Trial Updated:
05/06/2025
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Hormonal Gender-Affirming Therapy
Register for Updates
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
NCT04867317
Recruiting
The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild traumatic brain injury (mTBI).
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
05/06/2025
Locations: Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
Conditions: Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury
Register for Updates
Interventional Study Exploring the Occurrence of Surgical Site Infections.
NCT06661473
Recruiting
Interventional study exploring surgical site complication occurrences in high-risk revision patients undergoing TKA or THA using NPWT.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Twin Cities Orthopedics, Minneapolis, Minnesota
Conditions: Total Knee Arthroplasty, Total Hip Arthroplasty Revision, Total Knee Arthroplasty Revision
Register for Updates
Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy
NCT06543446
Recruiting
The investigators aim to compare the risk of mortality of Non-implantable carioverter defibrillator (ICD) vs. ICD management in patients with heart failure with reduced ejection fraction (HFrEF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Conditions: Heart Failure with Reduced Ejection Fraction
Register for Updates
Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC
NCT06197308
Recruiting
This pilot clinical trial will evaluate the initial safety and feasibility of microbiota transplant therapy (MTT) inpatients with primary sclerosing cholangitis (PSC). This trial will inform development of future trials in treatment of PSC.
Gender:
ALL
Ages:
Between 18 years and 76 years
Trial Updated:
05/05/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Primary Sclerosing Cholangitis
Register for Updates
Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
NCT06029972
Recruiting
The goal of this study is to learn if tilpisertib fosmecarbil (formerly known as GS-5290) is effective and safe in treating participants with moderate to severe ulcerative colitis. The study will compare participants in different treatment groups treated with tilpisertib fosmecarbil with participants treated with placebo. The primary objective of this study is to demonstrate the efficacy of tilpisertib fosmecarbil, compared to placebo control, in achieving Clinical Response at Week 12.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/05/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Ulcerative Colitis
Register for Updates
A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)
NCT05600426
Recruiting
Severe Aplastic Anemia (SAA) is a rare condition in which the body stops producing enough new blood cells. SAA can be cured with immune suppressive therapy or a bone marrow transplant. Regular treatment for patients with aplastic anemia who have a matched sibling (brother or sister), or family donor is a bone marrow transplant. Patients without a matched family donor normally are treated with immune suppressive therapy (IST). Match unrelated donor (URD) bone marrow transplant (BMT) is used as a... Read More
Gender:
ALL
Ages:
Between 0 years and 25 years
Trial Updated:
05/05/2025
Locations: Mayo Clinic Rochestser, Rochester, Minnesota
Conditions: Severe Aplastic Anemia
Register for Updates
HEAL-IST IDE Trial
NCT05280093
Recruiting
Inappropriate Sinus Tachycardia (IST) is a prevalent and debilitating condition in otherwise healthy younger patients, resulting in significant loss of quality of life, lacking effective treatment options or systematic clinical evidence to support a therapy. The primary objective of this clinical trial is to evaluate the safety and effectiveness of a hybrid sinus node sparing ablation procedure for the treatment of symptomatic drug refractory or drug intolerant IST.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/05/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Inappropriate Sinus Tachycardia
Register for Updates
Diabetes RElated to Acute Pancreatitis and Its Mechanisms
NCT05197920
Recruiting
The overriding objective of DREAM is to conduct a prospective longitudinal (36 months) observational clinical study to investigate the incidence, etiology, and pathophysiology of diabetes mellitus (DM) following acute pancreatitis (AP).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/05/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Acute Pancreatitis
Register for Updates