Minnesota is currently home to 2065 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Polyethylene Wear Particle Analysis of THA
NCT06432543
Recruiting
Purpose of research The purpose of this study was to demonstrate that polyethylene (Vitamin E-containing polyethylene), a newly introduced biomaterial for tibial inserts in hip replacement surgery and widely used clinically, but whose mid- to long-term clinical results are still unknown, is superior to conventional polyethylene in vivo. The aim of this project is to conduct an international multi-center joint research study to determine whether polyethylene wear debris production can be reduced... Read More
Gender:
ALL
Ages:
20 years and above
Trial Updated:
01/16/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Wear of Articular Bearing Surface of Prosthetic Joint, Hip Arthropathy
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A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)
NCT06346067
Recruiting
Stage 1: To select the optimal dose of naporafenib + trametinib to be studied in Stage 2. Stage 2: To compare progression free survival (PFS) and overall survival (OS) for patients with NRAS-mutant (NRASm) melanoma who are randomized to receive the combination of naporafenib + trametinib to that of patients who are randomized to physician's choice of therapy (dacarbazine, temozolomide, or trametinib monotherapy).
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
01/16/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Advanced or Metastatic NRAS-mutant Melanoma
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A Prosthetic Foot Test-Drive Strategy for Improving Stability in Veterans With Leg Amputations
NCT05473065
Recruiting
Objective/Hypotheses and Specific Aims: The first aim of this proposal is to determine the effects of commercial prosthetic feet of varying stiffness on stability and falls-related outcomes in Veterans with TTA. The second aim is to determine whether a PFE can be used to predict stability and balance-confidence outcomes with corresponding commercial prosthetic feet. The third and final aim is to determine whether a brief trial of commercial prosthetic feet can predict longer-term stability and b... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
01/16/2025
Locations: Minneapolis VA Medical Center, Minneapolis, Minnesota
Conditions: Amputation
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Trial of 225Ac-DOTATATE (RYZ101) in Subjects with ER+, HER2-negative Unresectable or Metastatic Breast Cancer Expressing SSTRs.
NCT06590857
Recruiting
Phase 1b/2 open-label trial of 225Ac-DOTATATE (RYZ101) in subjects with ER+, HER2-negative unresectable or metastatic breast cancer expressing SSTRs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: Research Facility, Rochester, Minnesota
Conditions: Metastatic Breast Cancer, HER2-negative Breast Cancer, ER+ Breast Cancer, Advanced Breast Cancer
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Study to Evaluate the Efficacy and Safety of Subcutaneous Sonelokimab Compared with Placebo in Adult Participants with Moderate to Severe Hidradenitis Suppurativa
NCT06411379
Recruiting
This is a study to evaluate the clinical efficacy and safety of sonelokimab administered subcutaneously compared with placebo in the treatment of adult participants with moderate to severe hidradenitis suppurativa. Participants will be randomized 2:1 to either sonelokimab or matching placebo up to Week 16.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: Clinical Site, New Brighton, Minnesota
Conditions: Hidradenitis Suppurativa
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Intrarenal Microvasculature in ADPKD
NCT05288998
Recruiting
The primary objective of this study is to evaluate the use of Super-resolution ultrasound (SRU) to assess the intrarenal microvasculature in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and healthy volunteers.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
01/15/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Autosomal Dominant Polycystic Kidney Disease
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Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
NCT04867317
Recruiting
The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild traumatic brain injury (mTBI).
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
01/15/2025
Locations: Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
Conditions: Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury
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Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
NCT04344769
Recruiting
The purpose of this study is to characterize oxidative stress and the Nrf2 antioxidant response in early stages of Autosomal Dominant Polycystic Kidney Disease (ADPKD), while identifying candidate biomarkers.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
01/15/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Autosomal Dominant Polycystic Kidney Disease
Register for Updates
Insulin Regulation of Lipolysis and Lipolysis Proteins
NCT03866408
Recruiting
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
01/15/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Obesity
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Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study
NCT02740634
Recruiting
This is a neuroimaging study designed to learn more about amyloid and tau burden in the brain of patients with typical and atypical Alzheimer's Disease and how burden may change over a one year period.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
01/15/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Atypical Alzheimer's Disease, Logopenic Progressive Aphasia (LPA), Posterior Cortical Atrophy (PCA), Alzheimer Disease, Alzheimer Disease, Early Onset, Amnestic Disorder, Amnestic Symptoms, Amnestic Mild Cognitive Disorder
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Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.
NCT06692920
Recruiting
When a patient gets DBS surgery, the neurosurgeon makes a hole in the skull through which they can put the DBS lead down in deep parts of the brain that help control movement. For this study, research participants will also have an ECoG strip put through the same hole (no extra holes are being made for research purposes). The ECoG strip is a little less than half an inch wide, and a little more than 2.5 inches long. It is very, very thin; it is a thin plastic film with flat metal sensors that ca... Read More
Gender:
ALL
Ages:
Between 21 years and 75 years
Trial Updated:
01/14/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson Disease
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Probiotic in Patients With Bile Acid Malabsorption/Diarrhea
NCT06609148
Recruiting
The purpose of this study is to assess effect of the DSF probiotic on fecal bile acid levels in patients with BAM.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Bile Acid Malabsorption, Bile Acid Diarrhea
Register for Updates