Minnesota is currently home to 2069 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies
NCT05488548
Recruiting
A Phase 1, first-in-human study of EP31670, a dual BET and CBP/p300 inhibitor in patients with targeted advanced solid tumors and Hematological Malignancies
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/12/2025
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Castrate Resistant Prostate Cancer, NUT Carcinoma, Chronic Myelomonocytic Leukemia, Myelofibrosis
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Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM
NCT06081894
Recruiting
This clinical trial will study the effects of aficamten (versus placebo) on the quality of life, exercise capacity, and clinical outcomes of patients with non-obstructive hypertrophic cardiomyopathy.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/11/2025
Locations: M Health Fairview University of Minnesota Medical Center - East Bank, Minneapolis, Minnesota
Conditions: Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy
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Phase 1 BIO 300 Oral Suspension
NCT06741345
Recruiting
This is a two-part study of BIO 300 Oral Suspension in healthy male and female volunteers. The first part is a multiple ascending dose (MAD) study to test the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the drug when given as daily doses over 14 days. The study will enroll three cohorts each receiving a different daily dose: 2000 mg, 3000 mg, or 4000 mg. A fourth group may be added depending on results on the first three cohorts. Each cohort will include 10 participants (5 men, 5... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
01/10/2025
Locations: Nucleus Network, LLC, Saint Paul, Minnesota
Conditions: Healthy Volunteer Study
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Tissue Destruction and Healing in Celiac Disease
NCT05680012
Recruiting
The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells, microbiota, immune system, genetics, and gluten and their effect on celiac disease clinical symptoms, and severity of tissue destruction and its ability to heal in individuals with celiac disease. Information collected in the study will help researchers to generate bett... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
01/10/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Celiac Disease
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A Study to Compare the Effectiveness of Different High-intensity Interval Training Programs in Cardiac Rehabilitation
NCT04555512
Recruiting
The purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/10/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cardiac Rehabilitation
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Clinical Transcriptomics in Systemic Vasculitis (CUTIS)
NCT03004326
Recruiting
Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
01/10/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis, Eosinophilic Granulomatosis With Polyangiitis (EGPA), IgA Vasculitis, Isolated Cutaneous Vasculitis, Granulomatosis With Polyangiitis (GPA), Microscopic Polyangiitis (MPA), Polyarteritis Nodosa (PAN), Urticarial Vasculitis, Vasculitis
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Steroids in Occipital Nerve Block for Treatment of Headache
NCT05732532
Recruiting
Currently there is limited evidence of benefit for the addition of steroids to occipital nerve blocks for treatment of headache, and not all steroids have been explored. The purpose of this research is to learn more about whether the addition of a specific kind of steroid (dexamethasone) provides any additional benefit to nerve blocks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Headache, Occipital Nerve Block
Register for Updates
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, the ERASur Study
NCT05673148
Recruiting
This phase III trial compares total ablative therapy and usual systemic therapy to usual systemic therapy alone in treating patients with colorectal cancer that has spread to up to 4 body sites (limited metastatic). The usual approach for patients who are not participating in a study is treatment with intravenous (IV) (through a vein) and/or oral medications (systemic therapy) to help stop the cancer sites from getting larger and the spread of the cancer to additional body sites. Ablative means... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Sanford Joe Lueken Cancer Center, Bemidji, Minnesota
Conditions: Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
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BEETroot Juice to Reverse Functional Impairment in PAD
NCT05624125
Recruiting
The BEET PAD Trial is a multi-centered double-blind randomized clinical trial designed to determine whether beetroot juice, compared to placebo, improves six-minute walk distance at four month follow-up in people with lower extremity peripheral artery disease (PAD). Investigators hypothesize that by simultaneously increasing lower extremity perfusion, gastrocnemius muscle mitochondrial activity, and myofiber health and regeneration, beetroot juice will significantly improve walking performance i... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
01/09/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Peripheral Artery Disease
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BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
NCT05456880
Recruiting
This is an open-label, single-arm, multicenter, Phase 1/2 study evaluating the safety and efficacy of the administration of autologous base edited CD34+ HSPCs (BEAM-101) in patients with severe SCD
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
01/09/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Sickle Cell Disease
Register for Updates
Intracardiac Flow Assessment in Cardiac Amyloidosis
NCT05379101
Recruiting
The primary objective of this study is to define the intracardiac flow imaging biomarkers in cardiac amyloidosis.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
01/09/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Amyloidosis Cardiac, Healthy Adults
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Poke and a Placebo
NCT04497220
Recruiting
To discover if a positive description of the procedure for an epidural can reduce the overall pain score associated with the procedure.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Anesthesia
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