Minnesota is currently home to 2085 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients with CtDNA-positive, Resected Stage II (high Risk) and Stage III Colorectal Cancer
NCT04486378
Recruiting
This is a multi-site, open-label, Phase II, randomized, trial to compare the efficacy of RO7198457 versus watchful waiting in patients with circulating tumor DNA (ctDNA) positive, surgically resected Stage II/III rectal cancer, or Stage II (high risk)/Stage III colon cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Allina Health, Minneapolis, Minnesota
Conditions: Colorectal Cancer Stage II, Colorectal Cancer Stage III
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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
NCT04045665
Recruiting
The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying POAF event, who decline randomization, will be offered the option of enrollment in a parallel registry that captures their ba... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Atrial Fibrillation, Stroke, Bleeding
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Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
NCT03868592
Recruiting
It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/05/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Obesity, Morbid
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Targeting Transdiagnostic Self-regulatory Factors and Eating Disorder Pathology Among Adults With BInge-spectrum Eating disOrders: A mHEALTH Interoceptive Exposure Intervention (the Bio-HEALTH Study)
NCT06631729
Recruiting
The present study will be fully remote (virtual) and include observational design features (assessments) plus a clinical trial. All assessments will be completed using HIPAA-approved platforms (e.g., Qualtrics, MindLogger EMA platform). After screening via Qualtrics to determine eligibility (described below), participants will complete a cross-sectional survey via Qualtrics, followed by a baseline EMA period. During the baseline EMA period, participants will receive brief (3-5 minutes) surveys o... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
02/04/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Eating Disorders
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Study to Evaluate the Safety and Effectiveness of the enVista® Beyond (EY) EDF Intraocular Lens in Subjects Undergoing Cataract Extraction
NCT06333015
Recruiting
This research study is evaluating the safety and efficacy (performance) of the Bausch + Lomb enVista Beyond Hydrophobic Acrylic Extended Depth of Focus Intraocular Lens (IOL) in subjects who receive this IOL in both eyes.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
02/04/2025
Locations: Site 107, Bloomington, Minnesota
Conditions: Cataract
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Evaluation of a Novel Auto Segmentation Algorithm for Normal Structure Delineation in Radiation Treatment Planning
NCT06200116
Recruiting
This study measures the utility of a novel artificial intelligence (AI) algorithm for performing auto-segmentation of computed tomography (CT) scans for radiation therapy planning.
Gender:
ALL
Ages:
All
Trial Updated:
02/04/2025
Locations: Mayo Clinic Health System in Albert Lea, Albert Lea, Minnesota
Conditions: Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm
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Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
NCT05205174
Recruiting
Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization's (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention.
Gender:
ALL
Ages:
All
Trial Updated:
02/04/2025
Locations: Hennepin County Medical Center, Minneapolis, Minnesota
Conditions: TBI (Traumatic Brain Injury)
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Blood Purification for the Treatment of Pathogen Associated Shock
NCT05011656
Recruiting
This study is a multi-center, randomized controlled feasibility trial to evaluate the initial safety and efficacy of a novel extracorporeal blood purification (EBP) therapy in critically ill patients with pathogen associated shock across 15 U.S. sites. Adults (18 years old and older) admitted to the ICU with all of the following: • Pathogen associated shock defined as: * The need for vasopressors to maintain mean arterial pressure (MAP) ≥ 65 mmHg despite adequate fluid resuscitation * Presence... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Septic Shock
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Watchman for Patients With Atrial Fibrillation Undergoing Transcatheter Mitral Valve Repair (WATCH-TMVR)
NCT04494347
Recruiting
WATCH-TMVR (Watchman for Patients with Atrial Fibrillation Undergoing Transcatheter Mitral Valve) Clinical Trial have the main objective to assess the feasibility of combining clinically indicated MitraClip TMVR and Watchman LAAO in one setting.Mayo Clinic will be the data coordinating center for this trial, which will include up to 3 sites.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Nonvalvular Atrial Fibrillation, Severe Degenerative Mitral Regurgitation
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A Randomized Multicenter Study for Isolated Skin Vasculitis
NCT02939573
Recruiting
Multi-center sequential multiple assignment randomized trial comparing the effectiveness of three different standard of care treatment options for patients with isolated skin vasculitis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Primary Cutaneous Vasculitis, Cutaneous Polyarteritis Nodosa, IgA Vasculitis, Henoch-Schönlein Purpura
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Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study
NCT06770062
Recruiting
The purpose of this research is to determine the feasibility of a larger, future study proposing a multimodal approach using cardiac CT and MRI to assess the risk of developing left ventricular (LV) systolic dysfunction in patients with mitral regurgitation (MR).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Left Ventricular Systolic Dysfunction
Register for Updates
Under-Resourced Adults with Chronic Pain EHealth Study
NCT06688864
Recruiting
The purpose of this study is to examine the feasibility of the dissemination of a cognitive-behavioral eHealth application (app) for pain self-management with Black and LGBTQ+ adults with high-impact chronic pain lasting at least 3 months and disrupting daily functioning (Implementation aim).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Chronic Pain
Register for Updates