Minnesota is currently home to 2106 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas
NCT04305444
Recruiting
Targeted drug therapies have greatly improved outcomes for patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma. However, single drug therapies have limitations, therefore, the current study is evaluating a novel oral combination of targeted drugs as a way of overcoming these limitations. This study will determine the efficacy of the triple combination therapy, DTRM-555, in patients with R/R CLL or R/R non-Hodgkin's lymphoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Relapsed Chronic Lymphocytic Leukemia, Refractory Chronic Lymphocytic Leukemia, Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Richter's Transformation
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Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment
NCT03891160
Recruiting
The purpose of this research study is to look at the advantages of using a 3D printed heart model for surgical planning in children who have been diagnosed with Congenital Heart Disease (CHD) and clinical heart failure and will undergo a ventricular assist device (VAD) placement. The investigators want to study the correlation of having a 3D printed model with improvement in patient outcomes and compare those with patients who have had a VAD placement without a 3D model.
Gender:
All
Ages:
All
Trial Updated:
04/26/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Congenital Heart Disease
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Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine
NCT05012358
Recruiting
This study is an observational longitudinal study involving the use of MRIs and video recordings taken at home of patients completing basic tasks. Once consent is obtained, subjects will be asked to schedule an appointment with radiology to undergo the listed MRIs of the heart and/or muscle. Subjects will also be given instructions on how to use the video recording app on their personal devices, or study provided device. The subjects will be followed regularly over the course of two years, submi... Read More
Gender:
All
Ages:
Between 15 years and 80 years
Trial Updated:
04/24/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Mitochondrial Myopathies, Mitochondrial DNA Mutation, Mitochondrial Diseases, Chronic Progressive External Ophthalmoplegia With Myopathy, Kearns-Sayre Syndrome
Register for Updates
KM3D Multicenter Cancer Consortium: Predicting Patient Response Using 3D Cell Culture Models
NCT05338073
Recruiting
This study will assess the ability of the Known Medicine platform to predict the efficacy of certain cancer drug treatments and to validate that tumor organoid drug sensitivity is representative of patient treatment outcomes.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/21/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Cancer, Predictive Cancer Model, Effects of Chemotherapy
Register for Updates
Performance Evaluation of Daily Disposable Contact Lenses in Habitual Lens Wearers Who Use Digital Devices Frequently
NCT05805150
Recruiting
The goal of this study is to compare the performance of two daily disposable silicone hydrogel lenses.
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
04/19/2023
Locations: Complete Eye Care of Medina/Complete Vision Solutions, Medina, Minnesota
Conditions: Myopia
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Post-Exablate Pregnancy Outcomes Registry Study: Exablate Treatment of Symptomatic Uterine Fibroids
NCT05386615
Recruiting
The goal of this Registry Study is to capture clinical pregnancy outcomes and fibroid treatment background data for any subject post-Exablate treatment for their symptomatic fibroids.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
04/19/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Uterine Fibroid
Register for Updates
EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy
NCT04921787
Recruiting
This study is a multi-site, cluster randomized, two group implementation trial comparing a low- versus high-intensity implementation strategy for supporting hospital-based opioid use disorder treatment (HBOT) in community hospital settings where medication for opioid use disorder (MOUD) treatment has not been implemented.
Gender:
All
Ages:
All
Trial Updated:
04/19/2023
Locations: Hennepin Healthcare Research Institute, Minneapolis, Minnesota
Conditions: Substance Use Disorders, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
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A Study of DF6002 Alone and in Combination With Nivolumab
NCT04423029
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug-levels, drug-effects and preliminary anti-tumor activity of DF6002 alone and in combination with Nivolumab in participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: HealthPartners Cancer Center at Regions Hospital, Saint Paul, Minnesota
Conditions: Solid Tumors
Register for Updates
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. Until recently, the mainstay of treatment for these patients was supportive medical care. Howe... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Spinal Muscular Atrophy (SMA)
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Non- vs Partial Controlled Weightbearing After Multiple Knee Ligament Reconstruction
NCT05073276
Recruiting
This is a prospective randomized controlled trial with the purpose to determine if patients undergoing isolated posterior cruciate ligament (PCL) reconstruction, or isolated medial collateral ligament (MCL) reconstruction, or combined PCL, anterior cruciate ligament (ACL), fibular collateral ligament (FCL), posterolateral corner (PLC), and MCL reconstructions (or any combination of multiple ligaments) can safely begin partial controlled weightbearing for the first six weeks after surgery.
Gender:
All
Ages:
Between 14 years and 59 years
Trial Updated:
04/12/2023
Locations: Twin Cities Orthopedics, Edina, Minnesota
Conditions: Knee Injuries
Register for Updates
Full Vs Partial Weightbearing During the First Six Weeks of Rehab. After Fibular Collateral Ligament Reconstruction
NCT05073263
Recruiting
This is a prospective randomized controlled trial with the purpose to determine if patients undergoing fibular collateral ligament (FCL) reconstruction alone or combined FCL and anterior cruciate ligament (ACL) reconstructions can safely begin full controlled weightbearing for the first six weeks after surgery.
Gender:
All
Ages:
Between 14 years and 59 years
Trial Updated:
04/12/2023
Locations: Twin Cities Orthopedics, Edina, Minnesota
Conditions: Knee Injuries
Register for Updates
FLEX FIRST Registry Research Protocol
NCT05616104
Recruiting
Prospective, observational study evaluating the clinical use and outcomes of the FLEX Vessel Prep (VP) system in arteriovenous fistulae or grafts presenting with clinical or hemodynamic abnormalities following 12 months post treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/11/2023
Locations: Minneapolis Vascular Surgery Center, New Brighton, Minnesota
Conditions: Arteriovenous Fistula, Arteriovenous Graft, Fistula, Arterial Occlusive Diseases
Register for Updates