Minnesota is currently home to 2095 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Enhanced Spatial Targeting in ECT Utilizing FEAST
NCT04099342
Recruiting
The purpose of this research study is to find an alternative version of ECT that reduces the negative side effects (mainly memory loss) while still providing patients with relief from depressive symptoms. Previous forms of ECT may use Bilateral (electrodes on both sides of the head) or Right Unilateral (RUL) (electrodes on one side of the head). Our research focuses on adjusting the placement of electrodes on one side of the head in order to better stimulate the Prefrontal Cortex (PFC) of the br... Read More
Gender:
ALL
Ages:
Between 22 years and 90 years
Trial Updated:
06/11/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Treatment Resistant Depression
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Neuromodulation and Cognitive Training in Opioid Use Disorder
NCT03773523
Recruiting
The relapsing nature of opioid use disorder is a major obstacle to successful treatment. About 90% of those entering treatment will relapse within one year. To improve treatment outcome, new interventions targeting the underlying brain biomarkers of relapse vulnerability hold significant promise in reducing this critical public health problem. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can modulate brain connectivity.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/11/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Opioid-use Disorder, Opioid Dependence, Opioid Abuse
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Vertical Sleeve Gastrectomy and Lifestyle Modification for the Treatment of Non-Alcoholic Steatohepatitis
NCT03587831
Recruiting
Participants meeting study entry criteria are randomized with equal probability to one of two study groups: (1) Lifestyle modification or (2) Vertical Sleeve Gastrectomy (VSG) with Iifestyle modification, followed for 12 months. The primary goal for the trial is to determine if the investigators can recruit, randomize, and retain participants to perform invasive and non-invasive measurements of NASH and fibrosis, deliver lifestyle modification and demonstrate the safety of VSG. The investigators... Read More
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
06/11/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: NASH - Nonalcoholic Steatohepatitis
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Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida
NCT06918119
Recruiting
A study to use transcutaneous spinal cord stimulation to characterize sensorimotor deficits in a pediatric population of individuals with spina bifida.
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
06/10/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Myelomeningocele, Spina Bifida
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Omnipod® SmartAdjust 2.0 System Compared to the Omnipod® 5 System in Individuals With Type 1 or Type 2 Diabetes
NCT06865989
Recruiting
The goal of this multi-center, randomized, cross-over study is to evaluate the safety and effectiveness of the Omnipod 5 SmartAdjust 2.0 System in individuals with type 1 or type 2 diabetes. Study participants will complete about 5 in-person visits and be expected to treat their diabetes per their usual routine using the system at the lowest available target setting. Each participant will begin the study using either the Omnipod 5 SmartAdjust 2.0 System or the Omnipod 5 System for 4 weeks (Per... Read More
Gender:
ALL
Ages:
Between 2 years and 70 years
Trial Updated:
06/10/2025
Locations: International Diabetes Center, Minneapolis, Minnesota
Conditions: Diabetes Mellitus, Type 1, Type 2
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Study of the Safety of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From Approximately 2 Months of Age
NCT06824194
Recruiting
This study is a Phase 3, randomized, modified double-blind study which aims to document the safety profile of the PCV21 vaccine (investigational pneumococcal vaccine) compared to a licensed 20-valent pneumococcal conjugate vaccine in infants aged from approximately 2 months (42 to 89 days). The study duration per participant will be up to approximately 19 months. The study vaccines (either PCV21 or 20vPCV) will be administered at approximately 2, 4, 6 and 12 to 15 months of age. Routine pediatr... Read More
Gender:
ALL
Ages:
Between 42 days and 89 days
Trial Updated:
06/10/2025
Locations: Clinical Research Institute - Minneapolis- Site Number : 8400002, Minneapolis, Minnesota
Conditions: Pneumococcal Immunization
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AI Noise Reduction in Phonak Hearing Aids
NCT06743295
Recruiting
The purpose of this study is to determine if artificial intelligence- based noise reduction can offer objective improvement in hearing and speech perception for hearing impaired patients.
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
06/10/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Hearing Loss
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A Study of Mobility Outcomes in Post-Pulmonary Embolic Disease
NCT06695247
Recruiting
The purpose of this study is to develop a unique structure and delivery of home-based exercise through multidisciplinary expertise of cardiovascular medicine specialists and cardiac physiologists using an Interactive Care Plan.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/10/2025
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Pulmonary Embolism
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Heidelberg Engineering ANTERION Software Comparison Study
NCT06657716
Recruiting
This study is conducted to compare the the investigational device ANTERION with software version 1.5 against the ANTERION with software version 1.2.4 (cleared version)
Gender:
ALL
Ages:
22 years and above
Trial Updated:
06/10/2025
Locations: Fischer Eye Laser Center, Wilmar, Minnesota
Conditions: Eyes With Normal Anterior Segment, Eyes With Abnormal Anterior Segment
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Comprehensive HHT Outcomes Registry of the United States (CHORUS)
NCT06259292
Recruiting
The Comprehensive HHT Outcomes Registry of the United States (CHORUS) is an observational registry of patients diagnosed with Hereditary Hemorrhagic Telangiectasia (HHT). The purpose of this study is to better understand HHT, the symptoms and complications it causes, and the impact the disease has on people's lives. The investigators will collect long-term information about the participant, allowing us to understand how the disease changes over time, and what factors can influence those changes.... Read More
Gender:
ALL
Ages:
All
Trial Updated:
06/10/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Hereditary Hemorrhagic Telangiectasia, Arteriovenous Malformations, Telangiectasia, Epistaxis, GastroIntestinal Bleeding, Cerebral Arteriovenous Malformations, Vascular Malformation
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Outcomes and Quality of Life Following Rectal Artery Embolization for Bleeding Internal Hemorrhoids
NCT06106269
Recruiting
This study will assess how effective and safe rectal artery embolization works to treat symptomatic bleeding predominant internal hemorrhoids.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
06/10/2025
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Internal Hemorrhoid
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Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
NCT06034405
Recruiting
Primary objective: To identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modifying therapies are most effective. The specific aims of this epidemiologic investigation include: 1. To identify subjects with previous lumbar spinal stenosis (LSS) Surgery who have evidence of transthyretin (TTR) amyloid deposits in spinal specimens and could be at risk for ATTR cardiac amyloidosis. 2. To evaluate for ATTR-CA among those... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/10/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Lumbar Spinal Stenosis, Cardiac Amyloidosis, ATTR Amyloidosis Wild Type, ATTR Gene Mutation, ATTRV122I Amyloidosis, Cardiomyopathy, Hypertrophic
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