Minnesota is currently home to 2085 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
SAfety of Regional Citrate Anticoagulation (SARCA Study)
NCT05339139
Recruiting
This is an Open-label, Prospective, Multicenter Study to Assess the SAfety of Regional Citrate Anticoagulation Delivered by the multiFiltratePRO system in Adult Patients Requiring Continuous Renal Replacement Therapy (SARCA Study).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Acute Kidney Injury, ESRD
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Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)
NCT04895436
Recruiting
Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess retreatment with venetoclax-obinutuzumab (VenG) in participants previously treated with fixed duration first-line (IL) therapy of venetoclax in combination with an anti-CD20 antibody +/- X (where X is any additional drug). Adverse events and change in disease activity will be assessed. Venetoclax is an approved drug for the treatment of CLL. Study doctors put the partic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: St. Luke's Hospital of Duluth /ID# 250021, Duluth, Minnesota
Conditions: Chronic Lymphocytic Leukemia (CLL)
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Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC
NCT04564989
Recruiting
The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with TRAF3 and CYLD mutations, and whether recurrence prediction improves when looking at HPV integration along with TRAF3 and CYLD mutations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Oropharyngeal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Head and Neck Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma
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Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study
NCT04550481
Recruiting
This phase II trial investigates how well lisinopril may work in preventing the progression of non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition where there is an accumulation of fatty cells in the liver. NAFLD increases a person's risk of developing liver cancer. Liver fibrosis is the common finding of chronic liver diseases leading to reduced liver function. Lisinopril is a medication that is commonly used to treat high blood pressure. Lisinopril may help to decrease liver fibros... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Nonalcoholic Steatohepatitis, Hepatocellular Carcinoma
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Pulmonary Hemodynamics During Exercise - Research Network
NCT03954574
Recruiting
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of Minnesota Medical School, Division of Cardiology, Department of Medicine, Lillehei Heart Institute Minneapolis, Minnesota, USA, Minneapolis, Minnesota
Conditions: Pulmonary Circulation Diseases
Register for Updates
Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD)
NCT03478826
Recruiting
To develop a repository of blood samples from patients with ILD to support future studies into the development of such biomarkers. Patients with pneumonia and healthy patients will also be recruited as a control group.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Interstitial Lung Disease
Register for Updates
A Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Elismetrep (K-304) in the Treatment of Migraine
NCT06848075
Recruiting
This is a double-blind, randomized, multicenter, outpatient evaluation of the safety and efficacy of elismetrep as compared to placebo in the treatment of moderate or severe migraine.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/22/2025
Locations: Clinical Research Institute, Minneapolis, Minnesota
Conditions: Acute Migraine
Register for Updates
Digital Remote Monitoring of Immune Checkpoint Inhibitor Therapy Induced Toxicity: A Feasibility Study of the Vigilant App (Vigilant-2)
NCT06675643
Recruiting
This study is being done to better understand patient experiences with using a mobile application, known as Vigilant, to monitor symptoms as outpatients and to gather preliminary data on the potential clinical benefit to remote monitoring of adverse events.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Malignant Skin Neoplasm, Melanoma
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A Study of Post COVID-19 Mechanisms for Chronic Lung Sequelae
NCT06006884
Recruiting
The purpose of this study is to understand why some people experience long term effects, such as shortness of breath and fatigue, after a severe COVID-19 infection
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: COVID-19
Register for Updates
Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS
NCT05918861
Recruiting
This is a placebo-controlled, randomized, double-blind, parallel group, phase 3 multicenter study in subjects recently hospitalized for ACS and with the appropriate genetic profile. Subjects will provide informed consent before any study-specific procedures are performed. A separate informed consent will be allowed for an initial pre-screening genetic testing. Subjects meeting the AA genotype will then consent to the full study and confirmatory genetic testing as required. Subject enrollment may... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
04/22/2025
Locations: Research Site, Coon Rapids, Minnesota
Conditions: Acute Coronary Syndrome
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Robotic vs. Open NSM for Early Stage Breast Cancer
NCT05720039
Recruiting
This study evaluates the safety and effectiveness of the da Vinci SP Surgical System compared to Open NSM in Nipple Sparing Mastectomy procedures.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
04/22/2025
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Breast Cancer Female, Breast Cancer, Breast Cancer, Early-Onset, Breast Disease, Breast
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ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System
NCT05686317
Recruiting
This is a prospective, multi-center, randomized, sham-controlled, double-blinded (participant and outcomes assessor) clinical trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Abbott Northwestern Hospital, Minneapolis, Minnesota
Conditions: Heart Failure
Register for Updates