There are currently 69 active clinical trials seeking participants for Insomnia research studies. The states with the highest number of trials for Insomnia participants are California, Florida, Texas and Ohio.
Digital Cognitive Behavioral Treatment of Insomnia in Youth: An RCT Examining Feasibility, Acceptability, and Efficacy of NiteCAPP Jr
NCT07091149
Recruiting
The proposed pilot will examine feasibility, acceptability, and preliminary efficacy of a digital CBT-I tailored for school-aged children.
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
07/28/2025
Locations: University of South Florida, Tampa, Florida
Conditions: Insomnia
Register for Updates
Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to < 18 Years With Insomnia Disorder
NCT05423717
Recruiting
This study assesses the efficacy, safety, and pharmacokinetics of multiple-dose oral administration of daridorexant in pediatric subjects aged 10 to \< 18 years with insomnia disorder.
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
07/25/2025
Locations: Banner - University Medical Center Tucson, Tucson, Arizona +49 locations
Conditions: Insomnia
Register for Updates
Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes
NCT05593653
Recruiting
The aim of this study is to determine if suvorexant can help treat the severity of insomnia in midlife women who are pre-diabetic.
Gender:
FEMALE
Ages:
Between 40 years and 65 years
Trial Updated:
07/22/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Insomnia, Diabetes, Menopause
Register for Updates
Treating Insomnia in Mild Cognitive Impairment
NCT06687161
Recruiting
The goal of this study is to test a new way to improve sleep quality in persons living with mild cognitive impairment. The treatment combines a safe and gentle way to stimulate the brain, called transcranial magnetic stimulation, with a psychological treatment, called cognitive behavioral therapy for insomnia.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
07/21/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Mild Cognitive Impairment (MCI), Insomnia
Register for Updates
Sleep as a Mechanism of Change in Alcohol Use
NCT06286774
Recruiting
This project aims to evaluate improvement of insomnia as a mechanism of improvement in alcohol use outcomes.
Gender:
ALL
Ages:
Between 18 years and 49 years
Trial Updated:
07/18/2025
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Insomnia, Alcohol; Harmful Use
Register for Updates
Suvorexant for Treatment of AUD and PTSD
NCT06679062
Recruiting
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD). All participants will have a 7-day placebo run-in period, followed by a random assignment to receive placebo or suvorexant for an additonal 14 days. Post-randomization, participants will attempt to stop drinking for two weeks and will complete daily virtual diaries and study outco... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
07/16/2025
Locations: University of California - Los Angeles, Los Angeles, California +1 locations
Conditions: Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD), Insomnia
Register for Updates
Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis
NCT06428006
Recruiting
The incidence of insomnia is estimated to be as high as 90% in individuals with MS due to insomnia being underdiagnosed. Sleep disturbances in people with MS have been associated with reduced cognitive performance, physical function, psychological well-being, quality of life, and occupational function, as well as increased prevalence of fatigue, pain, depression, and anxiety. The objective of the proposed study is to determine the efficacy of cognitive behavioral therapy for insomnia (CBT-I) to... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/16/2025
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Multiple Sclerosis, Insomnia
Register for Updates
Treatments for Insomnia in Veterans With PTSD
NCT05194930
Recruiting
This randomized trial will compare a novel treatment, Acceptance of the Behavioral Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I) among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder. ABC-I combines the behavioral components of CBT-I with components of another behavioral therapy (Acceptance and Commitment Therapy) and has been shown to improve treatment adherence. The study objectives are: 1) to evaluate the benefits of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: VA Greater Los Angeles Healthcare System, Sepulveda, CA, Sepulveda, California
Conditions: Insomnia, PTSD
Register for Updates
Targeting Insomnia to Improve Outcomes in Adults With Problematic Cannabis Use
NCT05814822
Recruiting
This study will compare the efficacy of telemedicine-delivered cognitive behavioral therapy for insomnia tailored for people using cannabis for sleep (CBTi-CB-TM) to telemedicine-delivered sleep hygiene education (SHE-TM) on sleep, cannabis use, and daytime functioning. We will also evaluate the effects of CBTi-CB-TM on fundamental sleep regulatory system - homeostatic sleep drive - and its association with clinical outcomes.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
07/01/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Insomnia
Register for Updates
Sleep Treatment Education Program for Cancer Survivors: STEP-Together
NCT06736548
Recruiting
This single-arm research study of off-treatment cancer survivors with self-reported symptoms of insomnia will test the Sleep Treatment Education Program Together (STEP-Together) intervention which is delivered as a synchronous group session by videoconference.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/01/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Insomnia, Insomnia Chronic, Survivorship
Register for Updates
Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects
NCT06981195
Recruiting
The goal of this clinical trial is to learn about how certain medications used to treat insomnia (e.g., Lemborexant) impact sleep, mood, and behavior in men and women with Opioid Use Disorder who are taking prescribed buprenorphine. The main questions it aims to answer are: 1. What is the effect of the study drug (lemborexant) on sleep outcomes? 2. What is the effect of the study drug (lemborexant) on impulsive behavior (as measured by computer test performance)? 3. What is the effect of the st... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: VCU Institute for Drug and Alcohol Studies, Richmond, Virginia
Conditions: Opioid Use Disorder, Opioid Use, Insomnia, Orexin Antagonist
Register for Updates
Wearable tES for Insomnia
NCT06100185
Recruiting
The purpose of this study is to investigate the ability of a translational device, Teledyne PeakSleep, to reduce sleep onset latency, reduce time awake after sleep onset and improve restfulness and the subjective benefits of sleep in a patient population with insomnia via transcranial direct current stimulation (tDCS) applied to frontal lobe circuits.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/25/2025
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Insomnia
Register for Updates